Matches in SemOpenAlex for { <https://semopenalex.org/work/W2969256828> ?p ?o ?g. }
- W2969256828 endingPage "103690" @default.
- W2969256828 startingPage "103690" @default.
- W2969256828 abstract "Staphylococcus aureus employs an arsenal of secreted virulence factors to evade host immune responses, such as inducing host cell death pathways or hiding within phagocytes. A previous study indicated that the transcription regulator SA1804 is a novel virulence repressor of S. aureus, and is regulated by SaeRS. However, the function of this regulator in S. aureus pathogenesis remains unclear. In this study, we created a SA1804 homologue, SAUSA300_1968, deletion mutant in the S. aureus USA300 strain LAC, and found that culture supernatant proteins of the mutant exhibit higher cytotoxicity and greater ability to induce the expression of inflammatory cytokines in mouse primary peritoneal macrophages as compared with that of its parent strain. Comparative proteome analysis of secreted protein expression profiles between the two strains was determined through tandem mass tags (TMT). Among the 18 well-known extracellular virulence-related factors that showed significantly different expressions, 17 proteins were up-regulated in the SAUSA300_1968 deletion mutant, including various pore-forming toxins and extracellular proteases. Accordingly, we also found that inactivation of SAUSA300_1968 enhanced S. aureus survival in mouse macrophages. Our data provide novel insights into the role of the SAUSA300_1968 regulator in host immune evasion and S. aureus pathogenesis." @default.
- W2969256828 created "2019-08-29" @default.
- W2969256828 creator A5004783384 @default.
- W2969256828 creator A5030777217 @default.
- W2969256828 creator A5031470939 @default.
- W2969256828 creator A5036124105 @default.
- W2969256828 creator A5047376984 @default.
- W2969256828 creator A5048718607 @default.
- W2969256828 creator A5052389563 @default.
- W2969256828 date "2019-11-01" @default.
- W2969256828 modified "2023-10-16" @default.
- W2969256828 title "Influence of transcription regulator SAUSA300_1968 on the virulence protein secretion and immune evasion by Staphylococcus aureus" @default.
- W2969256828 cites W1824339291 @default.
- W2969256828 cites W1848320945 @default.
- W2969256828 cites W1968161306 @default.
- W2969256828 cites W1970157828 @default.
- W2969256828 cites W1981793562 @default.
- W2969256828 cites W1986136996 @default.
- W2969256828 cites W1997528669 @default.
- W2969256828 cites W2002218478 @default.
- W2969256828 cites W2012061156 @default.
- W2969256828 cites W2012291430 @default.
- W2969256828 cites W2013319822 @default.
- W2969256828 cites W2014399796 @default.
- W2969256828 cites W2014967940 @default.
- W2969256828 cites W2017292954 @default.
- W2969256828 cites W2022147692 @default.
- W2969256828 cites W2042984912 @default.
- W2969256828 cites W2048280438 @default.
- W2969256828 cites W2050911379 @default.
- W2969256828 cites W2063859419 @default.
- W2969256828 cites W2068041880 @default.
- W2969256828 cites W2073828123 @default.
- W2969256828 cites W2094667070 @default.
- W2969256828 cites W2102647792 @default.
- W2969256828 cites W2105665201 @default.
- W2969256828 cites W2109486944 @default.
- W2969256828 cites W2110763275 @default.
- W2969256828 cites W2111188921 @default.
- W2969256828 cites W2119727748 @default.
- W2969256828 cites W2120254858 @default.
- W2969256828 cites W2122020611 @default.
- W2969256828 cites W2124908338 @default.
- W2969256828 cites W2127453904 @default.
- W2969256828 cites W2128294325 @default.
- W2969256828 cites W2130143969 @default.
- W2969256828 cites W2135918794 @default.
- W2969256828 cites W2138113489 @default.
- W2969256828 cites W2147978858 @default.
- W2969256828 cites W2149299339 @default.
- W2969256828 cites W2158472916 @default.
- W2969256828 cites W2158807953 @default.
- W2969256828 cites W2161587331 @default.
- W2969256828 cites W2162998751 @default.
- W2969256828 cites W2163264596 @default.
- W2969256828 cites W2171226404 @default.
- W2969256828 cites W2233828268 @default.
- W2969256828 cites W2285229669 @default.
- W2969256828 cites W2286083932 @default.
- W2969256828 cites W2293177725 @default.
- W2969256828 cites W2300793209 @default.
- W2969256828 cites W2314649741 @default.
- W2969256828 cites W2504133093 @default.
- W2969256828 cites W2528158691 @default.
- W2969256828 cites W2619583373 @default.
- W2969256828 cites W2791122892 @default.
- W2969256828 cites W2791623655 @default.
- W2969256828 cites W2884823586 @default.
- W2969256828 doi "https://doi.org/10.1016/j.micpath.2019.103690" @default.
- W2969256828 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31445123" @default.
- W2969256828 hasPublicationYear "2019" @default.
- W2969256828 type Work @default.
- W2969256828 sameAs 2969256828 @default.
- W2969256828 citedByCount "1" @default.
- W2969256828 countsByYear W29692568282020 @default.
- W2969256828 crossrefType "journal-article" @default.
- W2969256828 hasAuthorship W2969256828A5004783384 @default.
- W2969256828 hasAuthorship W2969256828A5030777217 @default.
- W2969256828 hasAuthorship W2969256828A5031470939 @default.
- W2969256828 hasAuthorship W2969256828A5036124105 @default.
- W2969256828 hasAuthorship W2969256828A5047376984 @default.
- W2969256828 hasAuthorship W2969256828A5048718607 @default.
- W2969256828 hasAuthorship W2969256828A5052389563 @default.
- W2969256828 hasConcept C104317684 @default.
- W2969256828 hasConcept C143065580 @default.
- W2969256828 hasConcept C181199279 @default.
- W2969256828 hasConcept C182220744 @default.
- W2969256828 hasConcept C203014093 @default.
- W2969256828 hasConcept C2779489039 @default.
- W2969256828 hasConcept C2781090273 @default.
- W2969256828 hasConcept C28406088 @default.
- W2969256828 hasConcept C49039625 @default.
- W2969256828 hasConcept C523546767 @default.
- W2969256828 hasConcept C54355233 @default.
- W2969256828 hasConcept C55493867 @default.
- W2969256828 hasConcept C60987743 @default.
- W2969256828 hasConcept C6929976 @default.
- W2969256828 hasConcept C86803240 @default.