FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2969262129> ?p ?o ?g. }

• W2969262129 abstract "Background Aedes aegypti is a prominent and highly competent vector of several arboviral diseases, including dengue, yellow fever and Zika. Behaviours associated with reproductive feeding, both pre- and post-blood meal, directly influence disease transmission capacity. Odours mediate host seeking pre-blood meal, while post-blood meal females are refractory to host odours for at least 24 h. During this time, flight activity is substantially reduced. Two key host odours, carbon dioxide and (R)-1-octen-3-ol, are detected by the maxillary palps in mosquitoes. In the search for future vector control tools, the identification of genes that are regulated in the maxillary palps between host seeking and 24 h post-blood meal may provide an informative pool of targets. Results The blood meal-induced regulation of chemosensory, neuromodulatory and other signal transduction genes was investigated in the maxillary palps of 24 h post-blood fed Ae. aegypti females, six days after emergence, and compared to host-seeking females of the same age using a transcriptomic approach. Genes-of-interest implicated in the behavioural switch from host seeking to post-blood meal quiescence were identified from multiple gene families investigated: odorant receptors, ionotropic receptors, pickpocket receptors, transient receptor potential receptors, odorant binding proteins, chemosensory proteins, neuromodulators and their receptors, as well as constituents of second messenger signalling pathways. Reflecting the change in transcript abundance of families involved in CO2 signalling, the neural sensitivity to this key kairomone compound was found to decrease in blood fed mosquitoes compare with their on-blood fed counter parts. Conclusions Sensory-associated gene expression is regulated in the maxillary palps of Ae. aegypti females in response to blood feeding. The concerted regulation of multiple genes within the sensory pathways of the maxillary palps likely play a key role in modulating the behavioural changes observed post-blood meal. Future functional characterization of the proteins generated by the genes-of-interest identified in this study may provide both a better understanding of the regulation of gonotrophic feeding and a pool of potential targets for vector control strategies." @default.
• W2969262129 created "2019-08-29" @default.
• W2969262129 creator A5002990910 @default.
• W2969262129 creator A5021633821 @default.
• W2969262129 creator A5072103159 @default.
• W2969262129 date "2019-09-10" @default.
• W2969262129 modified "2023-10-12" @default.
• W2969262129 title "Blood Meal Induced Regulation of Gene Expression in the Maxillary Palps, a Chemosensory Organ of the Mosquito Aedes aegypti" @default.
• W2969262129 cites W1498913998 @default.
• W2969262129 cites W1546880338 @default.
• W2969262129 cites W1745330220 @default.
• W2969262129 cites W1753924902 @default.
• W2969262129 cites W1944692219 @default.
• W2969262129 cites W1960950781 @default.
• W2969262129 cites W1965123365 @default.
• W2969262129 cites W1965969384 @default.
• W2969262129 cites W1966063464 @default.
• W2969262129 cites W1967468987 @default.
• W2969262129 cites W1967617980 @default.
• W2969262129 cites W1970090667 @default.
• W2969262129 cites W1973951377 @default.
• W2969262129 cites W1982124226 @default.
• W2969262129 cites W1982860159 @default.
• W2969262129 cites W1989753378 @default.
• W2969262129 cites W1990268963 @default.
• W2969262129 cites W1996674462 @default.
• W2969262129 cites W1999739739 @default.
• W2969262129 cites W2002956979 @default.
• W2969262129 cites W2006076804 @default.
• W2969262129 cites W2006370644 @default.
• W2969262129 cites W2006501334 @default.
• W2969262129 cites W2009200360 @default.
• W2969262129 cites W2014105498 @default.
• W2969262129 cites W2014845998 @default.
• W2969262129 cites W2017799436 @default.
• W2969262129 cites W2021903377 @default.
• W2969262129 cites W2023394368 @default.
• W2969262129 cites W2025127797 @default.
• W2969262129 cites W2028864332 @default.
• W2969262129 cites W2033111008 @default.
• W2969262129 cites W2034711534 @default.
• W2969262129 cites W2036266071 @default.
• W2969262129 cites W2036909529 @default.
• W2969262129 cites W2042059357 @default.
• W2969262129 cites W2042620313 @default.
• W2969262129 cites W2042969699 @default.
• W2969262129 cites W2047703671 @default.
• W2969262129 cites W2051438256 @default.
• W2969262129 cites W2051899340 @default.
• W2969262129 cites W2054478667 @default.
• W2969262129 cites W2065228852 @default.
• W2969262129 cites W2065275899 @default.
• W2969262129 cites W2069730262 @default.
• W2969262129 cites W2071172366 @default.
• W2969262129 cites W2075925574 @default.
• W2969262129 cites W2078997561 @default.
• W2969262129 cites W2079649610 @default.
• W2969262129 cites W2081986958 @default.
• W2969262129 cites W2084811410 @default.
• W2969262129 cites W2087465979 @default.
• W2969262129 cites W2088794269 @default.
• W2969262129 cites W2092538906 @default.
• W2969262129 cites W2100588760 @default.
• W2969262129 cites W2101081613 @default.
• W2969262129 cites W2101477533 @default.
• W2969262129 cites W2101786683 @default.
• W2969262129 cites W2102952974 @default.
• W2969262129 cites W2105218059 @default.
• W2969262129 cites W2105565132 @default.
• W2969262129 cites W2106791972 @default.
• W2969262129 cites W2107277218 @default.
• W2969262129 cites W2108459309 @default.
• W2969262129 cites W2108489599 @default.
• W2969262129 cites W2110909963 @default.
• W2969262129 cites W2113697161 @default.
• W2969262129 cites W2114578090 @default.
• W2969262129 cites W2116348125 @default.
• W2969262129 cites W2116999868 @default.
• W2969262129 cites W2120070471 @default.
• W2969262129 cites W2120285087 @default.
• W2969262129 cites W2120865735 @default.
• W2969262129 cites W2121102741 @default.
• W2969262129 cites W2127016153 @default.
• W2969262129 cites W2128405360 @default.
• W2969262129 cites W2130255659 @default.
• W2969262129 cites W2131398599 @default.
• W2969262129 cites W2131850946 @default.
• W2969262129 cites W2141889578 @default.
• W2969262129 cites W2150247460 @default.
• W2969262129 cites W2151503690 @default.
• W2969262129 cites W2156051194 @default.
• W2969262129 cites W2156761527 @default.
• W2969262129 cites W2162143951 @default.
• W2969262129 cites W2166454922 @default.
• W2969262129 cites W2168420558 @default.
• W2969262129 cites W2171846018 @default.
• W2969262129 cites W2224015589 @default.
• W2969262129 cites W2305981131 @default.
• W2969262129 cites W2469762386 @default.
• W2969262129 cites W2505917853 @default.

• next