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• W2969271775 startingPage "10107" @default.
• W2969271775 abstract "We examined the antiobesity effect of a limonoid 7-deacetoxy-7-oxogedunin, named CG-1, purified from the seeds of Carapa guianensis, Meliaceae, known as andiroba in high-fat-diet (HFD)-fed mice. C57BL/6 mice were fed a low-fat diet or an HFD and orally administered CG-1 (20 mg/kg) for 7 weeks. CG-1 lowered the body weight gain and improved the serum triglyceride level and insulin sensitivity in HFD-fed mice. The expression level of the adipogenesis-related genes was lowered by CG-1 in the visceral white adipose tissue (vWAT). The mRNA expression level of the macrophage-related genes decreased in vWAT following the administration of CG-1 to HFD-fed mice. It is noteworthy that CG-1 activated the brown adipose tissue (BAT) with enhanced expression of uncoupling protein 1 and increased the rectal temperature in HFD-fed mice. These results indicate that the limonoid CG-1 decreased body weight gain and ameliorated hypertriglyceridemia and insulin resistance with the activation of BAT in HFD-fed mice." @default.
• W2969271775 created "2019-08-29" @default.
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• W2969271775 date "2019-08-22" @default.
• W2969271775 modified "2023-10-18" @default.
• W2969271775 title "Limonoid 7-Deacetoxy-7-oxogedunin from Andiroba, <i>Carapa guianensis</i>, Meliaceae, Decreased Body Weight Gain, Improved Insulin Sensitivity, and Activated Brown Adipose Tissue in High-Fat-Diet-Fed Mice" @default.
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• W2969271775 doi "https://doi.org/10.1021/acs.jafc.9b04362" @default.
• W2969271775 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31434473" @default.
• W2969271775 hasPublicationYear "2019" @default.
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