Matches in SemOpenAlex for { <https://semopenalex.org/work/W2969291280> ?p ?o ?g. }
- W2969291280 endingPage "2697" @default.
- W2969291280 startingPage "2690" @default.
- W2969291280 abstract "Abstract Objectives Dolutegravir is widely prescribed owing to its potent antiviral activity, high genetic barrier and good tolerability. The aim of this study was to characterize dolutegravir’s pharmacokinetic profile and variability in a real-life setting and to identify individual factors and co-medications affecting dolutegravir disposition. Methods A population pharmacokinetic model was developed using NONMEM®. Relevant demographic factors, clinical factors and co-medications were tested as potential covariates. Simulations based on the final model served to compare expected dolutegravir concentrations under standard and alternative dosage regimens in the case of drug–drug interactions. Results A total of 620 dolutegravir plasma concentrations were collected from 521 HIV-infected individuals under steady-state conditions. A one-compartment model with first-order absorption and elimination best characterized dolutegravir pharmacokinetics. Typical dolutegravir apparent clearance (CL/F) was 0.93 L/h with 32% between-subject variability, the apparent volume of distribution was 20.2 L and the absorption rate constant was fixed to 2.24 h−1. Older age, higher body weight and current smoking were associated with higher CL/F. Atazanavir co-administration decreased dolutegravir CL/F by 38%, while darunavir modestly increased CL/F by 14%. Rifampicin co-administration showed the largest impact on CL/F. Simulations suggest that average dolutegravir trough concentrations are 63% lower after 50 mg/12h with rifampicin compared with a standard dosage of 50 mg/24h without rifampicin. Average trough concentrations after 100 mg/24h and 100 mg/12h with rifampicin are 92% and 25% lower than the standard dosage without rifampicin, respectively. Conclusions Patients co-treated with dolutegravir and rifampicin might benefit from therapeutic drug monitoring and individualized dosage increase, up to 100 mg/12 h in some cases." @default.
- W2969291280 created "2019-08-29" @default.
- W2969291280 creator A5003203523 @default.
- W2969291280 creator A5003503698 @default.
- W2969291280 creator A5005894491 @default.
- W2969291280 creator A5007165900 @default.
- W2969291280 creator A5010222793 @default.
- W2969291280 creator A5010759417 @default.
- W2969291280 creator A5011217027 @default.
- W2969291280 creator A5011657274 @default.
- W2969291280 creator A5012871288 @default.
- W2969291280 creator A5013001358 @default.
- W2969291280 creator A5014858344 @default.
- W2969291280 creator A5015098235 @default.
- W2969291280 creator A5017000023 @default.
- W2969291280 creator A5017260861 @default.
- W2969291280 creator A5017509777 @default.
- W2969291280 creator A5018546528 @default.
- W2969291280 creator A5020901993 @default.
- W2969291280 creator A5021189132 @default.
- W2969291280 creator A5022702528 @default.
- W2969291280 creator A5023115095 @default.
- W2969291280 creator A5026784994 @default.
- W2969291280 creator A5028829460 @default.
- W2969291280 creator A5029269504 @default.
- W2969291280 creator A5032116605 @default.
- W2969291280 creator A5033462113 @default.
- W2969291280 creator A5036017796 @default.
- W2969291280 creator A5037441803 @default.
- W2969291280 creator A5039985712 @default.
- W2969291280 creator A5041472567 @default.
- W2969291280 creator A5045122423 @default.
- W2969291280 creator A5046740811 @default.
- W2969291280 creator A5046807019 @default.
- W2969291280 creator A5047434629 @default.
- W2969291280 creator A5048977896 @default.
- W2969291280 creator A5049524331 @default.
- W2969291280 creator A5051183655 @default.
- W2969291280 creator A5052780767 @default.
- W2969291280 creator A5053142701 @default.
- W2969291280 creator A5059371192 @default.
- W2969291280 creator A5060727664 @default.
- W2969291280 creator A5061095609 @default.
- W2969291280 creator A5061951180 @default.
- W2969291280 creator A5062903597 @default.
- W2969291280 creator A5064236646 @default.
- W2969291280 creator A5068371713 @default.
- W2969291280 creator A5069244385 @default.
- W2969291280 creator A5070278395 @default.
- W2969291280 creator A5070365161 @default.
- W2969291280 creator A5078153174 @default.
- W2969291280 creator A5078674653 @default.
- W2969291280 creator A5080523158 @default.
- W2969291280 creator A5082208651 @default.
- W2969291280 creator A5082814419 @default.
- W2969291280 creator A5087513191 @default.
- W2969291280 creator A5088187599 @default.
- W2969291280 creator A5088630101 @default.
- W2969291280 creator A5089130646 @default.
- W2969291280 creator A5090315993 @default.
- W2969291280 creator A5090562208 @default.
- W2969291280 creator A5091042300 @default.
- W2969291280 creator A5091531260 @default.
- W2969291280 date "2019-05-22" @default.
- W2969291280 modified "2023-10-16" @default.
- W2969291280 title "Population pharmacokinetics of dolutegravir: influence of drug–drug interactions in a real-life setting" @default.
- W2969291280 cites W1505526182 @default.
- W2969291280 cites W1509307283 @default.
- W2969291280 cites W1653851471 @default.
- W2969291280 cites W1970755954 @default.
- W2969291280 cites W1984105526 @default.
- W2969291280 cites W1990925084 @default.
- W2969291280 cites W2003143162 @default.
- W2969291280 cites W2029701369 @default.
- W2969291280 cites W2042553471 @default.
- W2969291280 cites W2058734479 @default.
- W2969291280 cites W2071440341 @default.
- W2969291280 cites W2082883722 @default.
- W2969291280 cites W2085120686 @default.
- W2969291280 cites W2087478209 @default.
- W2969291280 cites W2098026442 @default.
- W2969291280 cites W2098185748 @default.
- W2969291280 cites W2104122452 @default.
- W2969291280 cites W2135955998 @default.
- W2969291280 cites W2151589354 @default.
- W2969291280 cites W2151945046 @default.
- W2969291280 cites W2152880150 @default.
- W2969291280 cites W2163256722 @default.
- W2969291280 cites W2286960341 @default.
- W2969291280 cites W2422955030 @default.
- W2969291280 cites W2554692247 @default.
- W2969291280 cites W2556153964 @default.
- W2969291280 cites W2600344958 @default.
- W2969291280 cites W2601165494 @default.
- W2969291280 cites W2608989554 @default.
- W2969291280 cites W2690342936 @default.
- W2969291280 cites W2755126513 @default.
- W2969291280 cites W2757413803 @default.