FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2969314156> ?p ?o ?g. }

• W2969314156 endingPage "114732" @default.
• W2969314156 startingPage "114732" @default.
• W2969314156 abstract "Endothelium inflammation has become a major risk factor for pathological development of atherosclerosis. IMM-H007 (H007), a small molecule compound, is previously reported to reduce inflammatory atherosclerosis. However, the regulatory role of H007 in endothelium inflammation is still unclear. Here, we characterize H007 as a critical repressor in regulation of endothelium inflammation. We find that H007 significantly inhibits monocyte adhesion to endothelial cells and its transendothelial migration. Mechanistically, H007 markedly represses TNFα-induced IκBα degradation and NF-κB nuclear translocation, therefore leading to NF-κB-mediated inflammatory suppression. Moreover, another inflammatory signaling JNK/c-Jun, which is always co-activated with NF-κB in response to pro-inflammatory stimuli, is also found to be restrained by H007 through reducing its phosphorylation status. Thus, we conclude that H007 negatively regulates endothelium inflammation through inactivating NF-κB and JNK/AP1 signaling. More importantly, this study provides us a new insight into understanding the molecular basis by which H007 regulates inflammatory atherosclerosis." @default.
• W2969314156 created "2019-08-29" @default.
• W2969314156 creator A5001545534 @default.
• W2969314156 creator A5006104038 @default.
• W2969314156 creator A5007468431 @default.
• W2969314156 creator A5037798401 @default.
• W2969314156 creator A5059427064 @default.
• W2969314156 creator A5061406271 @default.
• W2969314156 creator A5071065887 @default.
• W2969314156 date "2019-10-01" @default.
• W2969314156 modified "2023-09-26" @default.
• W2969314156 title "IMM-H007, a novel small molecule inhibitor for atherosclerosis, represses endothelium inflammation by regulating the activity of NF-κB and JNK/AP1 signaling" @default.
• W2969314156 cites W1164828748 @default.
• W2969314156 cites W1894363324 @default.
• W2969314156 cites W196835504 @default.
• W2969314156 cites W1983446204 @default.
• W2969314156 cites W1996685034 @default.
• W2969314156 cites W1998812648 @default.
• W2969314156 cites W2016289623 @default.
• W2969314156 cites W2017967250 @default.
• W2969314156 cites W2018893673 @default.
• W2969314156 cites W2025097039 @default.
• W2969314156 cites W2050737600 @default.
• W2969314156 cites W2051598492 @default.
• W2969314156 cites W2055211034 @default.
• W2969314156 cites W2060610804 @default.
• W2969314156 cites W2071787344 @default.
• W2969314156 cites W2072319964 @default.
• W2969314156 cites W2087592728 @default.
• W2969314156 cites W2106219216 @default.
• W2969314156 cites W2137174491 @default.
• W2969314156 cites W2143008467 @default.
• W2969314156 cites W2147204790 @default.
• W2969314156 cites W2172232070 @default.
• W2969314156 cites W2322523258 @default.
• W2969314156 cites W2397168475 @default.
• W2969314156 cites W2483464409 @default.
• W2969314156 cites W2735060622 @default.
• W2969314156 cites W2904687091 @default.
• W2969314156 cites W4247956906 @default.
• W2969314156 cites W4320996166 @default.
• W2969314156 doi "https://doi.org/10.1016/j.taap.2019.114732" @default.
• W2969314156 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31454633" @default.
• W2969314156 hasPublicationYear "2019" @default.
• W2969314156 type Work @default.
• W2969314156 sameAs 2969314156 @default.
• W2969314156 citedByCount "9" @default.
• W2969314156 countsByYear W29693141562020 @default.
• W2969314156 countsByYear W29693141562021 @default.
• W2969314156 countsByYear W29693141562022 @default.
• W2969314156 countsByYear W29693141562023 @default.
• W2969314156 crossrefType "journal-article" @default.
• W2969314156 hasAuthorship W2969314156A5001545534 @default.
• W2969314156 hasAuthorship W2969314156A5006104038 @default.
• W2969314156 hasAuthorship W2969314156A5007468431 @default.
• W2969314156 hasAuthorship W2969314156A5037798401 @default.
• W2969314156 hasAuthorship W2969314156A5059427064 @default.
• W2969314156 hasAuthorship W2969314156A5061406271 @default.
• W2969314156 hasAuthorship W2969314156A5071065887 @default.
• W2969314156 hasConcept C102280478 @default.
• W2969314156 hasConcept C104317684 @default.
• W2969314156 hasConcept C11960822 @default.
• W2969314156 hasConcept C123298856 @default.
• W2969314156 hasConcept C134018914 @default.
• W2969314156 hasConcept C17991360 @default.
• W2969314156 hasConcept C203014093 @default.
• W2969314156 hasConcept C2776914184 @default.
• W2969314156 hasConcept C2776992346 @default.
• W2969314156 hasConcept C2777730290 @default.
• W2969314156 hasConcept C2779730028 @default.
• W2969314156 hasConcept C2781184567 @default.
• W2969314156 hasConcept C502942594 @default.
• W2969314156 hasConcept C55493867 @default.
• W2969314156 hasConcept C62478195 @default.
• W2969314156 hasConcept C86339819 @default.
• W2969314156 hasConcept C86803240 @default.
• W2969314156 hasConcept C95444343 @default.
• W2969314156 hasConceptScore W2969314156C102280478 @default.
• W2969314156 hasConceptScore W2969314156C104317684 @default.
• W2969314156 hasConceptScore W2969314156C11960822 @default.
• W2969314156 hasConceptScore W2969314156C123298856 @default.
• W2969314156 hasConceptScore W2969314156C134018914 @default.
• W2969314156 hasConceptScore W2969314156C17991360 @default.
• W2969314156 hasConceptScore W2969314156C203014093 @default.
• W2969314156 hasConceptScore W2969314156C2776914184 @default.
• W2969314156 hasConceptScore W2969314156C2776992346 @default.
• W2969314156 hasConceptScore W2969314156C2777730290 @default.
• W2969314156 hasConceptScore W2969314156C2779730028 @default.
• W2969314156 hasConceptScore W2969314156C2781184567 @default.
• W2969314156 hasConceptScore W2969314156C502942594 @default.
• W2969314156 hasConceptScore W2969314156C55493867 @default.
• W2969314156 hasConceptScore W2969314156C62478195 @default.
• W2969314156 hasConceptScore W2969314156C86339819 @default.
• W2969314156 hasConceptScore W2969314156C86803240 @default.
• W2969314156 hasConceptScore W2969314156C95444343 @default.
• W2969314156 hasFunder F4320313796 @default.
• W2969314156 hasFunder F4320321001 @default.
• W2969314156 hasFunder F4320327311 @default.

• next