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- W2969316324 abstract "Objectives Microbiological diagnosis is essential during clinical management of focal infections. Metagenomic next generation sequencing (mNGS) has been reported as a promising diagnostic tool in infectious diseases. However, little is known about the clinical utility of mNGS in focal infections. Methods We conducted a single-center retrospective study to investigate impact of mNGS on focal infection diagnosis and compared it with conventional methods, including culture, pathological examination, Xpert MTB/RIF, etc. 98 suspected focal infections cases were enrolled, and medical records were reviewed to determine their rates of detection, time-to-identification, and clinical outcomes. Results mNGS showed a satisfying diagnostic positive percent agreement of 86.30% (95% CI: 75.79–92.88%) in a variety of tissues, compared to 45.21% (95% CI: 33.68–57.24%) for culture and 57.53% (95% CI: 45.43–68.84%)f for conventional methods (p < 0.0125), and detected an extra 34 pathogenic microorganisms. Time requirement for pathogen identification using mNGS ranges from 31 h to 55 h, which showed an advantage over culture. (82.36 h; 95%CI: 65.83, 98.89; P < 0.05) Conclusions mNGS showed promising potential in pathogenic diagnosis during focal infections and might enable clinicians to make more timely and targeted therapeutic decisions." @default.
- W2969316324 created "2019-08-29" @default.
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- W2969316324 date "2019-11-01" @default.
- W2969316324 modified "2023-10-12" @default.
- W2969316324 title "Incremental value of metagenomic next generation sequencing for the diagnosis of suspected focal infection in adults" @default.
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- W2969316324 doi "https://doi.org/10.1016/j.jinf.2019.08.012" @default.
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