FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2969316959> ?p ?o ?g. }

• W2969316959 abstract "The interest in liquid biopsy is growing because it could represent a non-invasive prognostic or predictive tool for clinical outcome in patients with pancreatic ductal adenocarcinoma (PDAC), an aggressive and lethal disease. In this pilot study, circulating tumor cells (CTCs), CD16 positive atypical CTCs and CTC clusters were captured and characterized in the blood of patients with PDAC before and after palliative first line chemotherapy by ScreenCell device, immunohistochemistry and confocal microscopy analysis. Gene profiles were performed by digital droplet PCR in isolated CTCs, five primary PDAC tissues and three different batches of RNA from normal human pancreatic tissue. Welsh’s t test, Kaplan-Meier survival and Univariate Cox regression analyses have been performed. Statistical analysis revealed that the presence of high CTC number in blood is a prognostic factor for poor overall survival and progression free survival in advanced PDAC patients, before and after first line chemotherapy. Furthermore, untreated PDAC patients with CTCs, characterized by high ALCAM, POU5F1B and SMO mRNAs expression, have shorter progression free survival and overall survival compared with patients expressing the same biomarkers at low levels. Finally, high SHH mRNA levels are negatively associated to PFS, whereas high vimentin mRNA levels are correlated with the most favorable prognosis. By hierarchical clustering and correlation index analysis, two cluster gene signatures were identified in CTCs: the first, with high expression of VEGFA, NOTCH1, EPCAM, IHH, is the signature of PDAC patients before chemotherapy, whereas the second, with an enrichment in the expression of CD44, ALCAM and POU5F1B stemness and pluripotency genes, is reported after palliative chemotherapy. Overall our data support the clinic value of the identification of CTC’s specific biomarkers to improve the prognosis and the therapy in advanced PDAC patients." @default.
• W2969316959 created "2019-08-29" @default.
• W2969316959 creator A5007630725 @default.
• W2969316959 creator A5015406288 @default.
• W2969316959 creator A5019053015 @default.
• W2969316959 creator A5032531876 @default.
• W2969316959 creator A5035812888 @default.
• W2969316959 creator A5036243769 @default.
• W2969316959 creator A5054063272 @default.
• W2969316959 creator A5055462856 @default.
• W2969316959 creator A5079690240 @default.
• W2969316959 creator A5086612949 @default.
• W2969316959 creator A5089066322 @default.
• W2969316959 date "2019-09-10" @default.
• W2969316959 modified "2023-10-16" @default.
• W2969316959 title "Expression Profiling of Circulating Tumor Cells in Pancreatic Ductal Adenocarcinoma Patients: Biomarkers Predicting Overall Survival" @default.
• W2969316959 cites W1511190501 @default.
• W2969316959 cites W1947727969 @default.
• W2969316959 cites W1972469981 @default.
• W2969316959 cites W1982078244 @default.
• W2969316959 cites W1982732520 @default.
• W2969316959 cites W1995097523 @default.
• W2969316959 cites W2006132448 @default.
• W2969316959 cites W2013288847 @default.
• W2969316959 cites W2031191632 @default.
• W2969316959 cites W2039225116 @default.
• W2969316959 cites W2040775084 @default.
• W2969316959 cites W2050547995 @default.
• W2969316959 cites W2058569154 @default.
• W2969316959 cites W2059542621 @default.
• W2969316959 cites W2061876263 @default.
• W2969316959 cites W2079909854 @default.
• W2969316959 cites W2083780033 @default.
• W2969316959 cites W2089384927 @default.
• W2969316959 cites W2102198783 @default.
• W2969316959 cites W2141736773 @default.
• W2969316959 cites W2143350625 @default.
• W2969316959 cites W2149226292 @default.
• W2969316959 cites W2149562012 @default.
• W2969316959 cites W2151253787 @default.
• W2969316959 cites W2153011144 @default.
• W2969316959 cites W2170202192 @default.
• W2969316959 cites W2233161210 @default.
• W2969316959 cites W2276975311 @default.
• W2969316959 cites W2340014362 @default.
• W2969316959 cites W2420247920 @default.
• W2969316959 cites W2424295009 @default.
• W2969316959 cites W2430737022 @default.
• W2969316959 cites W2561980783 @default.
• W2969316959 cites W2565365091 @default.
• W2969316959 cites W2588429189 @default.
• W2969316959 cites W2590605805 @default.
• W2969316959 cites W2604982293 @default.
• W2969316959 cites W2624801872 @default.
• W2969316959 cites W2737655512 @default.
• W2969316959 cites W2765398339 @default.
• W2969316959 cites W2789321144 @default.
• W2969316959 cites W2789331122 @default.
• W2969316959 cites W2795194062 @default.
• W2969316959 cites W2797926876 @default.
• W2969316959 cites W2891595642 @default.
• W2969316959 cites W2907903894 @default.
• W2969316959 cites W2911188335 @default.
• W2969316959 cites W2911199336 @default.
• W2969316959 cites W2914111168 @default.
• W2969316959 cites W2917919815 @default.
• W2969316959 cites W4244578979 @default.
• W2969316959 cites W4251777538 @default.
• W2969316959 doi "https://doi.org/10.3389/fonc.2019.00874" @default.
• W2969316959 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6746928" @default.
• W2969316959 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31552188" @default.
• W2969316959 hasPublicationYear "2019" @default.
• W2969316959 type Work @default.
• W2969316959 sameAs 2969316959 @default.
• W2969316959 citedByCount "43" @default.
• W2969316959 countsByYear W29693169592020 @default.
• W2969316959 countsByYear W29693169592021 @default.
• W2969316959 countsByYear W29693169592022 @default.
• W2969316959 countsByYear W29693169592023 @default.
• W2969316959 crossrefType "journal-article" @default.
• W2969316959 hasAuthorship W2969316959A5007630725 @default.
• W2969316959 hasAuthorship W2969316959A5015406288 @default.
• W2969316959 hasAuthorship W2969316959A5019053015 @default.
• W2969316959 hasAuthorship W2969316959A5032531876 @default.
• W2969316959 hasAuthorship W2969316959A5035812888 @default.
• W2969316959 hasAuthorship W2969316959A5036243769 @default.
• W2969316959 hasAuthorship W2969316959A5054063272 @default.
• W2969316959 hasAuthorship W2969316959A5055462856 @default.
• W2969316959 hasAuthorship W2969316959A5079690240 @default.
• W2969316959 hasAuthorship W2969316959A5086612949 @default.
• W2969316959 hasAuthorship W2969316959A5089066322 @default.
• W2969316959 hasBestOaLocation W29693169591 @default.
• W2969316959 hasConcept C10515644 @default.
• W2969316959 hasConcept C121608353 @default.
• W2969316959 hasConcept C126322002 @default.
• W2969316959 hasConcept C142724271 @default.
• W2969316959 hasConcept C143998085 @default.
• W2969316959 hasConcept C204232928 @default.
• W2969316959 hasConcept C2779013556 @default.
• W2969316959 hasConcept C502942594 @default.

• next