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- W2969317304 abstract "The metabolic transition from anaerobic glycolysis and fatty acid β‐oxidation to glycolysis coupled to oxidative phosphorylation is a key process for the transition of quiescent neural stem cells to proliferative neural progenitor cells. However, a full characterization of the metabolic shift and the involvement of mitochondria during the last step of neurogenesis, from neuroblasts to neuron maturation, is still elusive. Here, we describe a model of neuroblasts, Neuro2a cells, with impaired differentiation capacity due to mitochondrial dysfunction. Using a detailed biochemical characterization consisting of steady‐state metabolomics and metabolic flux analysis, we find increased fatty acid β‐oxidation as a peculiar feature of neuroblasts with altered mitochondria. The consequent metabolic switch favors neuroblast proliferation at the expense of neuron maturation." @default.
- W2969317304 created "2019-08-29" @default.
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- W2969317304 date "2019-08-31" @default.
- W2969317304 modified "2023-09-28" @default.
- W2969317304 title "Mitochondrial dysfunction increases fatty acid β‐oxidation and translates into impaired neuroblast maturation" @default.
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- W2969317304 doi "https://doi.org/10.1002/1873-3468.13584" @default.
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