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• W2969333463 abstract "The anti-inflammatory property of polydatin, a natural active ingredient found in the rhizome of Polygonum cuspidatum, has been verified. Although a variety of physiological functions have been uncovered, the protective effects and mechanism of polydatin on LPS-induced acute kidney injury remain unclear. Kidney histological change, MDA content, MPO activity, TNF-α, IL-1β, and IL-6 production were measured in this study. Furthermore, NF-κB and Nrf2 were tested by western blotting. In this study, polydatin not only significantly attenuated serum creatinine and BUN levels, but also remarkably inhibited TNF-α, IL-1β, and IL-6 production, MPO activity, and MDA content. Polydatin significantly inhibited LPS-induced NF-κB activation. Also, polydatin significantly increased Nrf2 and HO-1 expression. Taken together, all the above results indicate that polydatin had protective effects against LPS-induced AKI by blocking inflammatory and oxidative responses." @default.
• W2969333463 created "2019-08-29" @default.
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• W2969333463 date "2019-12-01" @default.
• W2969333463 modified "2023-09-23" @default.
• W2969333463 title "Polydatin prevents LPS-induced acute kidney injury through inhibiting inflammatory and oxidative responses" @default.
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• W2969333463 doi "https://doi.org/10.1016/j.micpath.2019.103688" @default.
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