FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2969342605> ?p ?o ?g. }

• W2969342605 endingPage "104" @default.
• W2969342605 startingPage "77" @default.
• W2969342605 abstract "Human sodium-glucose cotransporter 2 (hSGLT2) is a membrane protein responsible for glucose reabsorption from the glomerular filtrate in the proximal tubule. Inhibition of hSGLT2 has been regarded as a brand new therapeutic approach for the treatment of type 2 diabetes mellitus (T2DM) due to its non-insulin related characteristics with less side effects. Current commercially available hSGLT2 inhibitors are all C-glycoside inhibitors. Previous studies have reported that N-glycoside inhibitors have better potential to serve as new drugs due to their good metabolic stability. In addition, non-glycoside inhibitors have been shown to exhibit the capability to overcome the existing problems of current glycoside inhibitors, including low tissue permeability, poor stability and short serum half-time. Here, we aimed to discover novel N-glycoside and non-glycoside hSGLT2 inhibitors by a combination of several computational approaches. A ligand-based pharmacophore model was generated, well validated and subsequently utilized as a 3D query to identify novel hSGLT2 inhibitors from National Cancer Institute (NCI) and Traditional Chinese Medicine (TCM) databases. Finally, one N-glycoside (NSC679207) and one non-glycoside (TCM_Piperenol_A) hSGLT2 inhibitors were successfully identified, which were proven to exhibit excellent binding affinities, pharmacokinetic properties and less toxicity than the commercially available hSGLT2 inhibitor, canagliflozin, via molecular docking, ADMET prediction, molecular dynamics (MD) simulations and binding free energy calculations. All together, our results strongly suggest that these two compounds have great potential to serve as novel hSGLT2 inhibitors for the treatment of T2DM and their efficacies may be further examined by a series of in vitro and/or in vivo bioassays." @default.
• W2969342605 created "2019-08-29" @default.
• W2969342605 creator A5016897491 @default.
• W2969342605 creator A5046852323 @default.
• W2969342605 creator A5077613511 @default.
• W2969342605 creator A5090324198 @default.
• W2969342605 date "2019-01-01" @default.
• W2969342605 modified "2023-09-25" @default.
• W2969342605 title "Discovery of Novel N-Glycoside and Non-Glycoside hSGLT2 Inhibitors for the Treatment of Type 2 Diabetes Mellitus" @default.
• W2969342605 cites W1603231983 @default.
• W2969342605 cites W1964228799 @default.
• W2969342605 cites W1975864978 @default.
• W2969342605 cites W1978481514 @default.
• W2969342605 cites W1982261994 @default.
• W2969342605 cites W1994666960 @default.
• W2969342605 cites W2002760082 @default.
• W2969342605 cites W2011384425 @default.
• W2969342605 cites W2014531748 @default.
• W2969342605 cites W2014858249 @default.
• W2969342605 cites W2017417437 @default.
• W2969342605 cites W2025709931 @default.
• W2969342605 cites W2036227043 @default.
• W2969342605 cites W2037651276 @default.
• W2969342605 cites W2039104561 @default.
• W2969342605 cites W2044172327 @default.
• W2969342605 cites W2048279649 @default.
• W2969342605 cites W2049519918 @default.
• W2969342605 cites W2062108517 @default.
• W2969342605 cites W2069150029 @default.
• W2969342605 cites W2070579138 @default.
• W2969342605 cites W2075562501 @default.
• W2969342605 cites W2077132017 @default.
• W2969342605 cites W2086860898 @default.
• W2969342605 cites W2096380466 @default.
• W2969342605 cites W2105649494 @default.
• W2969342605 cites W2113551073 @default.
• W2969342605 cites W2118342742 @default.
• W2969342605 cites W2119186881 @default.
• W2969342605 cites W2123370748 @default.
• W2969342605 cites W2123775627 @default.
• W2969342605 cites W2124840360 @default.
• W2969342605 cites W2135732933 @default.
• W2969342605 cites W2144173715 @default.
• W2969342605 cites W2144288821 @default.
• W2969342605 cites W2145073071 @default.
• W2969342605 cites W2147993766 @default.
• W2969342605 cites W2149170824 @default.
• W2969342605 cites W2149185387 @default.
• W2969342605 cites W2149906170 @default.
• W2969342605 cites W2156053468 @default.
• W2969342605 cites W2161605421 @default.
• W2969342605 cites W2170536985 @default.
• W2969342605 cites W2171268876 @default.
• W2969342605 cites W2178509179 @default.
• W2969342605 cites W2409528022 @default.
• W2969342605 cites W2468361502 @default.
• W2969342605 cites W2509533611 @default.
• W2969342605 cites W2513874912 @default.
• W2969342605 cites W2516762108 @default.
• W2969342605 cites W2581920297 @default.
• W2969342605 cites W2707255742 @default.
• W2969342605 cites W2730056025 @default.
• W2969342605 cites W2749309302 @default.
• W2969342605 cites W2772835527 @default.
• W2969342605 cites W2773068270 @default.
• W2969342605 cites W2792618424 @default.
• W2969342605 cites W2794506696 @default.
• W2969342605 cites W2807239802 @default.
• W2969342605 cites W2810428191 @default.
• W2969342605 cites W2883722299 @default.
• W2969342605 cites W2888722616 @default.
• W2969342605 cites W2951454768 @default.
• W2969342605 cites W44929223 @default.
• W2969342605 cites W901067443 @default.
• W2969342605 doi "https://doi.org/10.4236/jdm.2019.93009" @default.
• W2969342605 hasPublicationYear "2019" @default.
• W2969342605 type Work @default.
• W2969342605 sameAs 2969342605 @default.
• W2969342605 citedByCount "4" @default.
• W2969342605 countsByYear W29693426052021 @default.
• W2969342605 countsByYear W29693426052022 @default.
• W2969342605 crossrefType "journal-article" @default.
• W2969342605 hasAuthorship W2969342605A5016897491 @default.
• W2969342605 hasAuthorship W2969342605A5046852323 @default.
• W2969342605 hasAuthorship W2969342605A5077613511 @default.
• W2969342605 hasAuthorship W2969342605A5090324198 @default.
• W2969342605 hasBestOaLocation W29693426051 @default.
• W2969342605 hasConcept C134018914 @default.
• W2969342605 hasConcept C159110408 @default.
• W2969342605 hasConcept C170493617 @default.
• W2969342605 hasConcept C185592680 @default.
• W2969342605 hasConcept C194671627 @default.
• W2969342605 hasConcept C2777451236 @default.
• W2969342605 hasConcept C2910068830 @default.
• W2969342605 hasConcept C3018795828 @default.
• W2969342605 hasConcept C41685203 @default.
• W2969342605 hasConcept C55493867 @default.
• W2969342605 hasConcept C555293320 @default.

• next