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- W2969343797 abstract "A series of 1,2,4-benzothiadiazine-1,1-dioxides bearing a sulfonylthiourea moiety were synthesized, characterized, and screened for their antioxidant activity, using six antioxidant analytical assays comparatively to reference compounds, ascorbic acid and quercetin. The results indicated that several compounds demonstrated strong antioxidant activity in DPPH, ABTS, H 2 O 2 , and lipid peroxidation assays where some of them were either as active as or more active than reference compounds. However, all compounds were largely less active than references compounds in the reducing power assay. The results indicated that the thiourea moiety probably played a crucial role in the antioxidant activity of the target compounds, as a thiolate ion. The most favorable R 1 groups were the hydrogen atom and methyl group, followed by phenyl and benzyl groups, whereas the most favorable R 2 group was iPr, followed by the phenyl and methyl groups. The combination of benzothiadiazine ring with sulfonylthiourea moieties led to valuable new antioxidants, which could be used in the treatment or the prevention of certain diseases or in the field of cosmetics, which needs further investigations in the future." @default.
- W2969343797 created "2019-08-29" @default.
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- W2969343797 date "2019-12-01" @default.
- W2969343797 modified "2023-09-27" @default.
- W2969343797 title "Synthesis, characterization, and investigation of the antioxidant activity of some 1,2,4-benzothiadiazine-1,1-dioxides bearing sulfonylthioureas moieties" @default.
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- W2969343797 doi "https://doi.org/10.1139/cjc-2019-0194" @default.
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