Matches in SemOpenAlex for { <https://semopenalex.org/work/W2969343929> ?p ?o ?g. }
- W2969343929 abstract "Microsporidia are important opportunistic human pathogens in immune-suppressed individuals, such as those with HIV/AIDS and recipients of organ transplants. The sporoplasm is critical for establishing microsporidian infection. Despite the biological importance of this structure for transmission, there is limited information about its structure and composition that could be targeted for therapeutic intervention. Here, we identified a novel E. hellem sporoplasm surface protein, EhSSP1, and demonstrated that it can bind to host cell mitochondria via host VDAC. Our data strongly suggest that the interaction between SSP1 and VDAC is important for the association of mitochondria with the parasitophorous vacuole during microsporidian infection. In addition, binding of SSP1 to the host cell is associated with the final steps of invasion in the invasion synapse." @default.
- W2969343929 created "2019-08-29" @default.
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- W2969343929 date "2019-08-27" @default.
- W2969343929 modified "2023-10-17" @default.
- W2969343929 title "Microsporidia Interact with Host Cell Mitochondria via Voltage-Dependent Anion Channels Using Sporoplasm Surface Protein 1" @default.
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- W2969343929 doi "https://doi.org/10.1128/mbio.01944-19" @default.
- W2969343929 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6703431" @default.
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- W2969343929 hasPublicationYear "2019" @default.
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