FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2969356232> ?p ?o ?g. }

• W2969356232 endingPage "491" @default.
• W2969356232 startingPage "484" @default.
• W2969356232 abstract "BackgroundThe TOBY-Xe proof of concept randomised trial found no effect of xenon combined with hypothermia after birth asphyxia on the lactate to N-acetyl aspartate ratio (Lac/NAA) in the thalamus and fractional anisotropy (FA) in white matter tracts measured within 15 days of birth. To confirm that these biomarkers are qualified to predict long-term outcome after neural rescue therapy we assessed surviving participants at 2–3 years of age.MethodsOf the 92 infants in TOBY-Xe, one was omitted from the study, 69 survived and we assessed 62 participants, 32 in the hypothermia and xenon and 30 in the hypothermia only groups. We examined the relation between Lac/NAA and FA and the scores of the Bayley Scales of Infant and Toddler Development III and calculated their predictive accuracy for moderate or severe disability or death.ResultsFifteen of 62 participants (24%) developed moderate/severe disability, and 22/92 (24%) died.The Lac/NAA ratio (difference in medians 0.628, 95% CI -0.392 to 4.684) and FA (difference in means −0.055, 95% CI -0.033 to −0.077) differed significantly between participants with or without moderate or severe disability or death and were significantly related with development scores in both groups. Adverse outcomes were correctly identified in 95.65% of cases by Lac/NAA and 78.79% by FA, with adequate mean calibration of the model.InterpretationThe results confirm the qualification of the cerebral magnetic resonance biomarkers employed in the TOBY-Xe study as predictors of outcome after neuroprotective therapy.FundThe Centre for the Developing Brain, King's College London, UK." @default.
• W2969356232 created "2019-08-29" @default.
• W2969356232 creator A5001110677 @default.
• W2969356232 creator A5001690656 @default.
• W2969356232 creator A5002812780 @default.
• W2969356232 creator A5010431865 @default.
• W2969356232 creator A5023239581 @default.
• W2969356232 creator A5043856880 @default.
• W2969356232 creator A5087495678 @default.
• W2969356232 date "2019-09-01" @default.
• W2969356232 modified "2023-10-02" @default.
• W2969356232 title "Prospective qualification of early cerebral biomarkers in a randomised trial of treatment with xenon combined with moderate hypothermia after birth asphyxia" @default.
• W2969356232 cites W1976546614 @default.
• W2969356232 cites W1988501897 @default.
• W2969356232 cites W2006132927 @default.
• W2969356232 cites W2021980996 @default.
• W2969356232 cites W2028541880 @default.
• W2969356232 cites W2052871219 @default.
• W2969356232 cites W2062395320 @default.
• W2969356232 cites W2090633287 @default.
• W2969356232 cites W2093577835 @default.
• W2969356232 cites W2100881622 @default.
• W2969356232 cites W2112321151 @default.
• W2969356232 cites W2113048472 @default.
• W2969356232 cites W2162045320 @default.
• W2969356232 cites W2195629230 @default.
• W2969356232 cites W2206541338 @default.
• W2969356232 cites W2296910921 @default.
• W2969356232 cites W2415026943 @default.
• W2969356232 cites W2526584780 @default.
• W2969356232 cites W2608465407 @default.
• W2969356232 cites W2900490565 @default.
• W2969356232 doi "https://doi.org/10.1016/j.ebiom.2019.08.034" @default.
• W2969356232 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6796501" @default.
• W2969356232 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31451436" @default.
• W2969356232 hasPublicationYear "2019" @default.
• W2969356232 type Work @default.
• W2969356232 sameAs 2969356232 @default.
• W2969356232 citedByCount "16" @default.
• W2969356232 countsByYear W29693562322020 @default.
• W2969356232 countsByYear W29693562322021 @default.
• W2969356232 countsByYear W29693562322022 @default.
• W2969356232 countsByYear W29693562322023 @default.
• W2969356232 crossrefType "journal-article" @default.
• W2969356232 hasAuthorship W2969356232A5001110677 @default.
• W2969356232 hasAuthorship W2969356232A5001690656 @default.
• W2969356232 hasAuthorship W2969356232A5002812780 @default.
• W2969356232 hasAuthorship W2969356232A5010431865 @default.
• W2969356232 hasAuthorship W2969356232A5023239581 @default.
• W2969356232 hasAuthorship W2969356232A5043856880 @default.
• W2969356232 hasAuthorship W2969356232A5087495678 @default.
• W2969356232 hasBestOaLocation W29693562321 @default.
• W2969356232 hasConcept C103728769 @default.
• W2969356232 hasConcept C118552586 @default.
• W2969356232 hasConcept C126322002 @default.
• W2969356232 hasConcept C138496976 @default.
• W2969356232 hasConcept C15744967 @default.
• W2969356232 hasConcept C164953862 @default.
• W2969356232 hasConcept C169900460 @default.
• W2969356232 hasConcept C188816634 @default.
• W2969356232 hasConcept C2777390192 @default.
• W2969356232 hasConcept C2778242525 @default.
• W2969356232 hasConcept C2779914510 @default.
• W2969356232 hasConcept C42219234 @default.
• W2969356232 hasConcept C71924100 @default.
• W2969356232 hasConceptScore W2969356232C103728769 @default.
• W2969356232 hasConceptScore W2969356232C118552586 @default.
• W2969356232 hasConceptScore W2969356232C126322002 @default.
• W2969356232 hasConceptScore W2969356232C138496976 @default.
• W2969356232 hasConceptScore W2969356232C15744967 @default.
• W2969356232 hasConceptScore W2969356232C164953862 @default.
• W2969356232 hasConceptScore W2969356232C169900460 @default.
• W2969356232 hasConceptScore W2969356232C188816634 @default.
• W2969356232 hasConceptScore W2969356232C2777390192 @default.
• W2969356232 hasConceptScore W2969356232C2778242525 @default.
• W2969356232 hasConceptScore W2969356232C2779914510 @default.
• W2969356232 hasConceptScore W2969356232C42219234 @default.
• W2969356232 hasConceptScore W2969356232C71924100 @default.
• W2969356232 hasLocation W29693562321 @default.
• W2969356232 hasLocation W29693562322 @default.
• W2969356232 hasLocation W29693562323 @default.
• W2969356232 hasLocation W29693562324 @default.
• W2969356232 hasLocation W29693562325 @default.
• W2969356232 hasLocation W29693562326 @default.
• W2969356232 hasLocation W29693562327 @default.
• W2969356232 hasOpenAccess W2969356232 @default.
• W2969356232 hasPrimaryLocation W29693562321 @default.
• W2969356232 hasRelatedWork W2087287102 @default.
• W2969356232 hasRelatedWork W2625206756 @default.
• W2969356232 hasRelatedWork W2751967772 @default.
• W2969356232 hasRelatedWork W2762846421 @default.
• W2969356232 hasRelatedWork W2884317507 @default.
• W2969356232 hasRelatedWork W2914346208 @default.
• W2969356232 hasRelatedWork W3126668286 @default.
• W2969356232 hasRelatedWork W3127926271 @default.
• W2969356232 hasRelatedWork W4281487236 @default.
• W2969356232 hasRelatedWork W4300535055 @default.
• W2969356232 hasVolume "47" @default.

• next