FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2969361716> ?p ?o ?g. }

• W2969361716 endingPage "e159" @default.
• W2969361716 startingPage "e150" @default.
• W2969361716 abstract "Pathologic complete response (pCR) has been shown to be associated with favorable outcomes in breast cancer. Predictors of pCR could be useful in guiding treatment decisions regarding neoadjuvant therapy. The objective of this study was to evaluate cyclin E as a predictor of response to neoadjuvant chemotherapy in breast cancer.Patients (n = 285) with stage II-III breast cancer were enrolled in a prospective study and received neoadjuvant chemotherapy with anthracyclines, taxanes, or combination of the two. Pretreatment biopsies from 190 patients and surgical specimens following chemotherapy from 192 patients were available for immunohistochemical analysis. Clinical and pathologic responses were recorded and associated with presence of tumor infiltrating lymphocytes, cyclin E, adipophilin, programmed cell death-ligand 1, and elastase staining and other patient, tumor and treatment characteristics.The pCR rate was significantly lower in patients with cytoplasmic cyclin E staining compared with those who had no cyclin E expression (16.1% vs 38.9%, P = 0.0005). In multivariable logistic regression analysis, the odds of pCR for patients who had cytoplasmic negative tumors was 9.35 times (P value < 0.0001) that compared with patients with cytoplasmic positive tumors after adjusting for ER, PR, and HER2 status. Cytoplasmic cyclin E expression also predicts long-term outcome and is associated with reduced disease free, recurrence free, and overall survival rates, independent of increased pretreatment tumor infiltrating lymphocytes.Cyclin E independently predicted response to neoadjuvant chemotherapy. Hence, its routine immunohistochemical analysis could be used clinically to identify those breast cancer patients expected to have a poor response to anthracycline/taxane-based chemotherapy." @default.
• W2969361716 created "2019-08-29" @default.
• W2969361716 creator A5011734599 @default.
• W2969361716 creator A5015127974 @default.
• W2969361716 creator A5017411324 @default.
• W2969361716 creator A5019367809 @default.
• W2969361716 creator A5032057886 @default.
• W2969361716 creator A5039812679 @default.
• W2969361716 creator A5041098535 @default.
• W2969361716 creator A5042960706 @default.
• W2969361716 creator A5049662911 @default.
• W2969361716 creator A5052218127 @default.
• W2969361716 creator A5064666735 @default.
• W2969361716 creator A5081974309 @default.
• W2969361716 creator A5084699825 @default.
• W2969361716 date "2019-08-20" @default.
• W2969361716 modified "2023-10-18" @default.
• W2969361716 title "Cytoplasmic Cyclin E Expression Predicts for Response to Neoadjuvant Chemotherapy in Breast Cancer" @default.
• W2969361716 cites W1889335134 @default.
• W2969361716 cites W1955397179 @default.
• W2969361716 cites W1971562495 @default.
• W2969361716 cites W1984107586 @default.
• W2969361716 cites W1985213644 @default.
• W2969361716 cites W1988993802 @default.
• W2969361716 cites W1995788690 @default.
• W2969361716 cites W2008280457 @default.
• W2969361716 cites W2073143212 @default.
• W2969361716 cites W2075894019 @default.
• W2969361716 cites W2081177143 @default.
• W2969361716 cites W2083035492 @default.
• W2969361716 cites W2090539023 @default.
• W2969361716 cites W2107485485 @default.
• W2969361716 cites W2112434826 @default.
• W2969361716 cites W2113165839 @default.
• W2969361716 cites W2114974670 @default.
• W2969361716 cites W2115961074 @default.
• W2969361716 cites W2119434445 @default.
• W2969361716 cites W2119549339 @default.
• W2969361716 cites W2120431466 @default.
• W2969361716 cites W2137487731 @default.
• W2969361716 cites W2147415463 @default.
• W2969361716 cites W2152121590 @default.
• W2969361716 cites W2153158488 @default.
• W2969361716 cites W2155454155 @default.
• W2969361716 cites W2157058802 @default.
• W2969361716 cites W2157250162 @default.
• W2969361716 cites W2163871197 @default.
• W2969361716 cites W2166615734 @default.
• W2969361716 cites W2167339883 @default.
• W2969361716 cites W2169798282 @default.
• W2969361716 cites W2171958606 @default.
• W2969361716 cites W2256481109 @default.
• W2969361716 cites W2291752147 @default.
• W2969361716 cites W2316247073 @default.
• W2969361716 cites W2394186663 @default.
• W2969361716 cites W2550633550 @default.
• W2969361716 cites W2588028576 @default.
• W2969361716 cites W2888408613 @default.
• W2969361716 cites W2889749263 @default.
• W2969361716 cites W2909799373 @default.
• W2969361716 doi "https://doi.org/10.1097/sla.0000000000003551" @default.
• W2969361716 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7031042" @default.
• W2969361716 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31436549" @default.
• W2969361716 hasPublicationYear "2019" @default.
• W2969361716 type Work @default.
• W2969361716 sameAs 2969361716 @default.
• W2969361716 citedByCount "3" @default.
• W2969361716 countsByYear W29693617162021 @default.
• W2969361716 countsByYear W29693617162023 @default.
• W2969361716 crossrefType "journal-article" @default.
• W2969361716 hasAuthorship W2969361716A5011734599 @default.
• W2969361716 hasAuthorship W2969361716A5015127974 @default.
• W2969361716 hasAuthorship W2969361716A5017411324 @default.
• W2969361716 hasAuthorship W2969361716A5019367809 @default.
• W2969361716 hasAuthorship W2969361716A5032057886 @default.
• W2969361716 hasAuthorship W2969361716A5039812679 @default.
• W2969361716 hasAuthorship W2969361716A5041098535 @default.
• W2969361716 hasAuthorship W2969361716A5042960706 @default.
• W2969361716 hasAuthorship W2969361716A5049662911 @default.
• W2969361716 hasAuthorship W2969361716A5052218127 @default.
• W2969361716 hasAuthorship W2969361716A5064666735 @default.
• W2969361716 hasAuthorship W2969361716A5081974309 @default.
• W2969361716 hasAuthorship W2969361716A5084699825 @default.
• W2969361716 hasBestOaLocation W29693617162 @default.
• W2969361716 hasConcept C121608353 @default.
• W2969361716 hasConcept C126322002 @default.
• W2969361716 hasConcept C142724271 @default.
• W2969361716 hasConcept C143998085 @default.
• W2969361716 hasConcept C199835354 @default.
• W2969361716 hasConcept C204232928 @default.
• W2969361716 hasConcept C2776694085 @default.
• W2969361716 hasConcept C2778292576 @default.
• W2969361716 hasConcept C29537977 @default.
• W2969361716 hasConcept C530470458 @default.
• W2969361716 hasConcept C71924100 @default.
• W2969361716 hasConceptScore W2969361716C121608353 @default.
• W2969361716 hasConceptScore W2969361716C126322002 @default.
• W2969361716 hasConceptScore W2969361716C142724271 @default.

• next