Matches in SemOpenAlex for { <https://semopenalex.org/work/W2969362013> ?p ?o ?g. }
- W2969362013 endingPage "4083" @default.
- W2969362013 startingPage "4083" @default.
- W2969362013 abstract "Pancreatic progenitor cells (PPCs) are the primary source for all pancreatic cells, including beta-cells, and thus the proliferation and differentiation of PPCs into islet-like cell clusters (ICCs) opens an avenue to providing transplantable islets for diabetic patients. Meanwhile, mesenchymal stem cells (MSCs) can enhance the development and function of different cell types of interest, but their role on PPCs remains unknown. We aimed to explore the mechanism-of-action whereby MSCs induce the in vitro and in vivo PPC/ICC development by means of our established co-culture system of human PPCs with human fetal bone marrow-derived MSCs. We examined the effect of MSC-conditioned medium on PPC proliferation and survival. Meanwhile, we studied the effect of MSC co-culture enhanced PPC/ICC function in vitro and in vivo co-/transplantation. Furthermore, we identified IGF1 as a critical factor responsible for the MSC effects on PPC differentiation and proliferation via IGF1-PI3K/Akt and IGF1-MEK/ERK1/2, respectively. In conclusion, our data indicate that MSCs stimulated the differentiation and proliferation of human PPCs via IGF1 signaling, and more importantly, promoted the in vivo engraftment function of ICCs. Taken together, our protocol may provide a mechanism-driven basis for the proliferation and differentiation of PPCs into clinically transplantable islets." @default.
- W2969362013 created "2019-08-29" @default.
- W2969362013 creator A5020579121 @default.
- W2969362013 creator A5024549935 @default.
- W2969362013 creator A5036839752 @default.
- W2969362013 date "2019-08-21" @default.
- W2969362013 modified "2023-09-30" @default.
- W2969362013 title "Human Fetal Bone Marrow-Derived Mesenchymal Stem Cells Promote the Proliferation and Differentiation of Pancreatic Progenitor Cells and the Engraftment Function of Islet-Like Cell Clusters" @default.
- W2969362013 cites W1541957617 @default.
- W2969362013 cites W1556383867 @default.
- W2969362013 cites W1764066238 @default.
- W2969362013 cites W1804670053 @default.
- W2969362013 cites W1967474814 @default.
- W2969362013 cites W1971353320 @default.
- W2969362013 cites W1974410142 @default.
- W2969362013 cites W1974452230 @default.
- W2969362013 cites W1975503903 @default.
- W2969362013 cites W1976742584 @default.
- W2969362013 cites W1979738387 @default.
- W2969362013 cites W1980200800 @default.
- W2969362013 cites W1984181807 @default.
- W2969362013 cites W1993672117 @default.
- W2969362013 cites W2004444822 @default.
- W2969362013 cites W2005826230 @default.
- W2969362013 cites W2005943573 @default.
- W2969362013 cites W2011831109 @default.
- W2969362013 cites W2012835372 @default.
- W2969362013 cites W2016395601 @default.
- W2969362013 cites W2025353471 @default.
- W2969362013 cites W2025779728 @default.
- W2969362013 cites W2025800771 @default.
- W2969362013 cites W2035641081 @default.
- W2969362013 cites W2043787237 @default.
- W2969362013 cites W2045159954 @default.
- W2969362013 cites W2045433259 @default.
- W2969362013 cites W2059286688 @default.
- W2969362013 cites W2060993312 @default.
- W2969362013 cites W2065349499 @default.
- W2969362013 cites W2069187276 @default.
- W2969362013 cites W2073087742 @default.
- W2969362013 cites W2081652171 @default.
- W2969362013 cites W2088500471 @default.
- W2969362013 cites W2089897360 @default.
- W2969362013 cites W2092328207 @default.
- W2969362013 cites W2095189993 @default.
- W2969362013 cites W2100126797 @default.
- W2969362013 cites W2101947332 @default.
- W2969362013 cites W2111236186 @default.
- W2969362013 cites W2111843196 @default.
- W2969362013 cites W2112777549 @default.
- W2969362013 cites W2118100479 @default.
- W2969362013 cites W2132313258 @default.
- W2969362013 cites W2133154776 @default.
- W2969362013 cites W2133368655 @default.
- W2969362013 cites W2134045039 @default.
- W2969362013 cites W2135606708 @default.
- W2969362013 cites W2136629350 @default.
- W2969362013 cites W2139887779 @default.
- W2969362013 cites W2152197131 @default.
- W2969362013 cites W2157396269 @default.
- W2969362013 cites W2160434297 @default.
- W2969362013 cites W2161783089 @default.
- W2969362013 cites W2169872175 @default.
- W2969362013 cites W2170493251 @default.
- W2969362013 cites W2288312973 @default.
- W2969362013 cites W2311972351 @default.
- W2969362013 cites W2337861353 @default.
- W2969362013 cites W2593391971 @default.
- W2969362013 cites W2902369084 @default.
- W2969362013 cites W4244207573 @default.
- W2969362013 doi "https://doi.org/10.3390/ijms20174083" @default.
- W2969362013 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6747176" @default.
- W2969362013 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31438545" @default.
- W2969362013 hasPublicationYear "2019" @default.
- W2969362013 type Work @default.
- W2969362013 sameAs 2969362013 @default.
- W2969362013 citedByCount "10" @default.
- W2969362013 countsByYear W29693620132020 @default.
- W2969362013 countsByYear W29693620132021 @default.
- W2969362013 countsByYear W29693620132022 @default.
- W2969362013 crossrefType "journal-article" @default.
- W2969362013 hasAuthorship W2969362013A5020579121 @default.
- W2969362013 hasAuthorship W2969362013A5024549935 @default.
- W2969362013 hasAuthorship W2969362013A5036839752 @default.
- W2969362013 hasBestOaLocation W29693620131 @default.
- W2969362013 hasConcept C104317684 @default.
- W2969362013 hasConcept C126322002 @default.
- W2969362013 hasConcept C134018914 @default.
- W2969362013 hasConcept C148738053 @default.
- W2969362013 hasConcept C150903083 @default.
- W2969362013 hasConcept C165220095 @default.
- W2969362013 hasConcept C198826908 @default.
- W2969362013 hasConcept C201750760 @default.
- W2969362013 hasConcept C203014093 @default.
- W2969362013 hasConcept C207001950 @default.
- W2969362013 hasConcept C2779306644 @default.
- W2969362013 hasConcept C2779855799 @default.
- W2969362013 hasConcept C2780007613 @default.