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- W2969365645 abstract "Abstract Medicinal plants belonging to the genus Ardisia are traditionally used to cure various human diseases including inflammation and cancer. This study aimed to purify and characterize cytotoxic and anti-inflammatory compounds from Ardisia sieboldii leaves. Bioassay-guided chromatographic analyses yielded three compounds, 2-methyl-5-(8 Z -heptadecenyl) resorcinol ( 1 ), 5-(8 Z -heptadecenyl) resorcinol ( 2 ), and ardisiaquinone A ( 3 ), whereas liquid chromatography–electrospray ionisation–mass spectrometry chemical profiling revealed the presence of diverse resorcinol and alkylbenzoquinone derivatives in cytotoxic 70% methanol extracts. Chemical structures of 1 – 3 were confirmed by spectroscopic methods including 1 H NMR (nuclear magnetic resonance), 13 C NMR, and electrospray ionisation–mass spectrometry. Compounds 1 and 2 were purified from A. sieboldii for the first time, and all three compounds showed cytotoxicity against a panel of cancer cell lines and brine shrimps in a dose-response manner. Among them, compound 2 exhibited the highest cytotoxicity on cancer cells (IC 50 values of 8.8–25.7 μM) as well as on brine shrimps (IC 50 value of 5.1 μM). Compounds 1 – 3 exhibited anti-inflammatory effects through inhibiting protein denaturation (IC 50 values of 5.8–9.6 μM), cyclooxygenase-2 activity (IC 50 values of 34.5–60.1 μM), and nitrite formation in RAW 264.7 cells. Cytotoxic and anti-inflammatory activities of 1 – 3 demonstrated in this study deserve further investigation for considering their suitability as candidates or leads to develop anticancer and anti-inflammatory drugs." @default.
- W2969365645 created "2019-08-29" @default.
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- W2969365645 date "2019-08-22" @default.
- W2969365645 modified "2023-09-29" @default.
- W2969365645 title "Cytotoxic and anti-inflammatory resorcinol and alkylbenzoquinone derivatives from the leaves of <i>Ardisia sieboldii</i>" @default.
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- W2969365645 doi "https://doi.org/10.1515/znc-2019-0114" @default.
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