FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2969377838> ?p ?o ?g. }

• W2969377838 endingPage "7053" @default.
• W2969377838 startingPage "7043" @default.
• W2969377838 abstract "Abstract Rheumatoid arthritis (RA)‐associated interstitial lung disease (ILD), a primary cause of mortality in patients with RA, has limited treatment options. A previously established RA model in D1CC transgenic mice aberrantly expressed major histocompatibility complex class II genes in joints, developing collagen II‐induced polyarthritis and anti‐cyclic citrullinated peptide antibodies and interstitial pneumonitis, similar to those in humans. Molecular hydrogen (H 2 ) is an efficient antioxidant that permeates cell membranes and alleviates the reactive oxygen species‐induced injury implicated in RA pathogenesis. We used D1CC mice to analyse chronic lung fibrosis development and evaluate H 2 treatment effects. We injected D1CC mice with type II collagen and supplied them with H 2 ‐rich or control water until analysis. Increased serum surfactant protein D values and lung densities images were observed 10 months after injection. Inflammation was patchy within the perilymphatic stromal area, with increased 8‐hydroxy‐2ʹ‐deoxyguanosine‐positive cell numbers and tumour necrosis factor‐α, BAX, transforming growth factor‐β, interleukin‐6 and soluble collagen levels in the lungs. Inflammatory and fibrotic changes developed diffusely within the perilymphatic stromal area, as observed in humans. H 2 treatment decreased these effects in the lungs. Thus, this model is valuable for studying the effects of H 2 treatment and chronic interstitial pneumonia pathophysiology in humans. H 2 appears to protect against RA‐ILD by alleviating oxidative stress." @default.
• W2969377838 created "2019-08-29" @default.
• W2969377838 creator A5003199689 @default.
• W2969377838 creator A5011282366 @default.
• W2969377838 creator A5017430491 @default.
• W2969377838 creator A5026858037 @default.
• W2969377838 creator A5030019495 @default.
• W2969377838 creator A5032988881 @default.
• W2969377838 creator A5034292099 @default.
• W2969377838 creator A5036084648 @default.
• W2969377838 creator A5041061791 @default.
• W2969377838 creator A5050504263 @default.
• W2969377838 creator A5063525907 @default.
• W2969377838 creator A5065103395 @default.
• W2969377838 creator A5088395139 @default.
• W2969377838 date "2019-08-19" @default.
• W2969377838 modified "2023-10-18" @default.
• W2969377838 title "Effect of H ₂ treatment in a mouse model of rheumatoid arthritis‐associated interstitial lung disease" @default.
• W2969377838 cites W1554023045 @default.
• W2969377838 cites W1575583315 @default.
• W2969377838 cites W1584738578 @default.
• W2969377838 cites W1963789809 @default.
• W2969377838 cites W1985525173 @default.
• W2969377838 cites W1996482353 @default.
• W2969377838 cites W1998716086 @default.
• W2969377838 cites W2001163363 @default.
• W2969377838 cites W2006408441 @default.
• W2969377838 cites W2013210087 @default.
• W2969377838 cites W2019537258 @default.
• W2969377838 cites W2030578737 @default.
• W2969377838 cites W2039448476 @default.
• W2969377838 cites W2039985020 @default.
• W2969377838 cites W2044183703 @default.
• W2969377838 cites W2045018966 @default.
• W2969377838 cites W2054017711 @default.
• W2969377838 cites W2056105585 @default.
• W2969377838 cites W2066143619 @default.
• W2969377838 cites W2075400164 @default.
• W2969377838 cites W2091214272 @default.
• W2969377838 cites W2093152540 @default.
• W2969377838 cites W2101611319 @default.
• W2969377838 cites W2108132563 @default.
• W2969377838 cites W2116951100 @default.
• W2969377838 cites W2122336434 @default.
• W2969377838 cites W2149239535 @default.
• W2969377838 cites W2159054927 @default.
• W2969377838 cites W2169657429 @default.
• W2969377838 cites W2401537340 @default.
• W2969377838 cites W2429814667 @default.
• W2969377838 cites W2471463846 @default.
• W2969377838 cites W2528225935 @default.
• W2969377838 cites W2530491403 @default.
• W2969377838 cites W2588935500 @default.
• W2969377838 cites W2912714652 @default.
• W2969377838 cites W39708689 @default.
• W2969377838 doi "https://doi.org/10.1111/jcmm.14603" @default.
• W2969377838 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6787460" @default.
• W2969377838 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31424157" @default.
• W2969377838 hasPublicationYear "2019" @default.
• W2969377838 type Work @default.
• W2969377838 sameAs 2969377838 @default.
• W2969377838 citedByCount "12" @default.
• W2969377838 countsByYear W29693778382020 @default.
• W2969377838 countsByYear W29693778382021 @default.
• W2969377838 countsByYear W29693778382022 @default.
• W2969377838 countsByYear W29693778382023 @default.
• W2969377838 crossrefType "journal-article" @default.
• W2969377838 hasAuthorship W2969377838A5003199689 @default.
• W2969377838 hasAuthorship W2969377838A5011282366 @default.
• W2969377838 hasAuthorship W2969377838A5017430491 @default.
• W2969377838 hasAuthorship W2969377838A5026858037 @default.
• W2969377838 hasAuthorship W2969377838A5030019495 @default.
• W2969377838 hasAuthorship W2969377838A5032988881 @default.
• W2969377838 hasAuthorship W2969377838A5034292099 @default.
• W2969377838 hasAuthorship W2969377838A5036084648 @default.
• W2969377838 hasAuthorship W2969377838A5041061791 @default.
• W2969377838 hasAuthorship W2969377838A5050504263 @default.
• W2969377838 hasAuthorship W2969377838A5063525907 @default.
• W2969377838 hasAuthorship W2969377838A5065103395 @default.
• W2969377838 hasAuthorship W2969377838A5088395139 @default.
• W2969377838 hasBestOaLocation W29693778381 @default.
• W2969377838 hasConcept C126322002 @default.
• W2969377838 hasConcept C142724271 @default.
• W2969377838 hasConcept C16930146 @default.
• W2969377838 hasConcept C203014093 @default.
• W2969377838 hasConcept C2777077863 @default.
• W2969377838 hasConcept C2777543607 @default.
• W2969377838 hasConcept C2777575956 @default.
• W2969377838 hasConcept C2777714996 @default.
• W2969377838 hasConcept C2778917330 @default.
• W2969377838 hasConcept C2780559512 @default.
• W2969377838 hasConcept C2780942790 @default.
• W2969377838 hasConcept C2781244666 @default.
• W2969377838 hasConcept C71924100 @default.
• W2969377838 hasConceptScore W2969377838C126322002 @default.
• W2969377838 hasConceptScore W2969377838C142724271 @default.
• W2969377838 hasConceptScore W2969377838C16930146 @default.
• W2969377838 hasConceptScore W2969377838C203014093 @default.

• next