FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2969409897> ?p ?o ?g. }

• W2969409897 endingPage "5460" @default.
• W2969409897 startingPage "5452" @default.
• W2969409897 abstract "Kruppel-like factor 2 (KLF2) has been found to regulate the reconstruction of vascular wall tissue and participate in the pathogenic mechanism of intracranial aneurysms. However, there is a paucity of research in this area. The present study aimed to investigate the regulatory effect of KLF2 on intracranial aneurysm (IA) and explore novel therapeutic strategies for treating IA. Experimental animal models were established with SPF New Zealand rabbits by bilateral carotid artery ligation (BCAL). Morphology of basilar artery bifurcation was detected using HE, EVG, Masson and immunohistochemical (IHC) staining. Vascular smooth muscle cells were harvested from basilar artery and cultured to establish KLF2 up-regulated and down-regulated cell models. The mRNA expression of KLF2, eNOS, ICAM-1 and MMP-9 were detected using real-time quantitate PCR (RT-qPCR). Protein expression of KLF2 and MAPKs pathway were measured using western blot. IA models were successfully established by bilateral carotid artery ligation. KLF2 expression was inconsistent with the variation of hemodynamics. In the KLF2 overexpression group, the mRNA expression of eNOS was increased, while that of ICAM-1 and MMP-9 was decreased. When KLF2 was up-regulated, the phosphorylation activity of p38 pathway was increased. In conclusion, results reveal that KLF2 is up-regulated in the vascular wall of basilar artery, and its overexpression regulates the pathogenesis of IA, which may be a self-protection mechanism of the arterial wall, providing a novel insight for therapy of IA." @default.
• W2969409897 created "2019-08-29" @default.
• W2969409897 creator A5034211965 @default.
• W2969409897 creator A5060985903 @default.
• W2969409897 creator A5069721762 @default.
• W2969409897 creator A5077063251 @default.
• W2969409897 creator A5078953626 @default.
• W2969409897 date "2017-01-01" @default.
• W2969409897 modified "2023-09-27" @default.
• W2969409897 title "Regulation of Kruppel-like factor 2 (KLF2) in the pathogenesis of intracranial aneurysm induced by hemodynamics." @default.
• W2969409897 cites W1965907417 @default.
• W2969409897 cites W1970081212 @default.
• W2969409897 cites W1983782712 @default.
• W2969409897 cites W2018525013 @default.
• W2969409897 cites W2034420653 @default.
• W2969409897 cites W2040222056 @default.
• W2969409897 cites W2041986831 @default.
• W2969409897 cites W2058328321 @default.
• W2969409897 cites W2070288742 @default.
• W2969409897 cites W2076118659 @default.
• W2969409897 cites W2076626545 @default.
• W2969409897 cites W2081529285 @default.
• W2969409897 cites W2091104996 @default.
• W2969409897 cites W2096685662 @default.
• W2969409897 cites W2100031693 @default.
• W2969409897 cites W2113880404 @default.
• W2969409897 cites W2137492070 @default.
• W2969409897 cites W2147107152 @default.
• W2969409897 cites W2170737950 @default.
• W2969409897 cites W2261821596 @default.
• W2969409897 cites W2339739687 @default.
• W2969409897 cites W2415599419 @default.
• W2969409897 cites W2467611256 @default.
• W2969409897 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5752895" @default.
• W2969409897 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29312497" @default.
• W2969409897 hasPublicationYear "2017" @default.
• W2969409897 type Work @default.
• W2969409897 sameAs 2969409897 @default.
• W2969409897 citedByCount "2" @default.
• W2969409897 countsByYear W29694098972019 @default.
• W2969409897 countsByYear W29694098972021 @default.
• W2969409897 crossrefType "journal-article" @default.
• W2969409897 hasAuthorship W2969409897A5034211965 @default.
• W2969409897 hasAuthorship W2969409897A5060985903 @default.
• W2969409897 hasAuthorship W2969409897A5069721762 @default.
• W2969409897 hasAuthorship W2969409897A5077063251 @default.
• W2969409897 hasAuthorship W2969409897A5078953626 @default.
• W2969409897 hasConcept C104317684 @default.
• W2969409897 hasConcept C105702510 @default.
• W2969409897 hasConcept C126322002 @default.
• W2969409897 hasConcept C142724271 @default.
• W2969409897 hasConcept C150194340 @default.
• W2969409897 hasConcept C178853913 @default.
• W2969409897 hasConcept C204232928 @default.
• W2969409897 hasConcept C2776415932 @default.
• W2969409897 hasConcept C2777350992 @default.
• W2969409897 hasConcept C2777622882 @default.
• W2969409897 hasConcept C2778326061 @default.
• W2969409897 hasConcept C2780942790 @default.
• W2969409897 hasConcept C2781012200 @default.
• W2969409897 hasConcept C519581460 @default.
• W2969409897 hasConcept C55493867 @default.
• W2969409897 hasConcept C71924100 @default.
• W2969409897 hasConcept C86803240 @default.
• W2969409897 hasConceptScore W2969409897C104317684 @default.
• W2969409897 hasConceptScore W2969409897C105702510 @default.
• W2969409897 hasConceptScore W2969409897C126322002 @default.
• W2969409897 hasConceptScore W2969409897C142724271 @default.
• W2969409897 hasConceptScore W2969409897C150194340 @default.
• W2969409897 hasConceptScore W2969409897C178853913 @default.
• W2969409897 hasConceptScore W2969409897C204232928 @default.
• W2969409897 hasConceptScore W2969409897C2776415932 @default.
• W2969409897 hasConceptScore W2969409897C2777350992 @default.
• W2969409897 hasConceptScore W2969409897C2777622882 @default.
• W2969409897 hasConceptScore W2969409897C2778326061 @default.
• W2969409897 hasConceptScore W2969409897C2780942790 @default.
• W2969409897 hasConceptScore W2969409897C2781012200 @default.
• W2969409897 hasConceptScore W2969409897C519581460 @default.
• W2969409897 hasConceptScore W2969409897C55493867 @default.
• W2969409897 hasConceptScore W2969409897C71924100 @default.
• W2969409897 hasConceptScore W2969409897C86803240 @default.
• W2969409897 hasIssue "12" @default.
• W2969409897 hasLocation W29694098971 @default.
• W2969409897 hasOpenAccess W2969409897 @default.
• W2969409897 hasPrimaryLocation W29694098971 @default.
• W2969409897 hasRelatedWork W1985774067 @default.
• W2969409897 hasRelatedWork W2041739593 @default.
• W2969409897 hasRelatedWork W2148878791 @default.
• W2969409897 hasRelatedWork W2182325410 @default.
• W2969409897 hasRelatedWork W2340011231 @default.
• W2969409897 hasRelatedWork W2354835554 @default.
• W2969409897 hasRelatedWork W2358606101 @default.
• W2969409897 hasRelatedWork W2413934364 @default.
• W2969409897 hasRelatedWork W2969409897 @default.
• W2969409897 hasRelatedWork W3021556762 @default.
• W2969409897 hasVolume "9" @default.
• W2969409897 isParatext "false" @default.
• W2969409897 isRetracted "false" @default.

• next