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- W2969429569 abstract "Linezolid and vancomycin are among the last-resort antimicrobial agents in the treatment of multidrug-resistant Gram-positive bacterial infections. Linezolid- and vancomycin-resistant (LVR) Gram-positive bacteria may pose severe threats to public health. In this study, three optrA- and vanG-positive Streptococcus suis strains were isolated from two farms of different cities. There were only 1 and 343 single-nucleotide polymorphisms in coding region (cSNPs) of HCB4 and YSJ7 to YSJ17, respectively. Mobilome analysis revealed the presence of vanG, erm(B), tet(O/W/32/O), and aadE-apt-sat4-aphA3 cluster on an integrative and conjugative element, ICESsuYSJ17, and erm(B), aphA3, aac(6')-aph(2″), catpC194, and optrA on a prophage, ΦSsuYSJ17-3. ICESsuYSJ17 exhibited a mosaic structure and belongs to a highly prevalent and transferable ICESa2603 family of Streptococcus species. ΦSsuYSJ17-3 shared conserved backbone to a transferable prophage Φm46.1. A novel composite transposon, IS1216E-araC-optrA-hp-catpC194-IS1216E, which can be circulated as translocatable unit (TU) by IS1216E, was integrated on ΦSsuYSJ17-3. Vancomycin resistance phenotype and vanG transcription assays revealed that the vanG operon was inducible. The LVR strain YSJ17 exhibited moderate virulence in a zebrafish infection model. To our knowledge, this is the first report of LVR isolate, which is mediated by acquired resistance genes optrA and vanG operons in Gram-positive bacteria. Since S. suis has been recognized as an antimicrobial resistance reservoir in the spread of resistance genes to major streptococcal pathogens, the potential risks of disseminating of optrA and vanG from S. suis to other Streptococcus spp. are worrisome and routine surveillance should be strengthened." @default.
- W2969429569 created "2019-08-29" @default.
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- W2969429569 date "2019-09-10" @default.
- W2969429569 modified "2023-10-18" @default.
- W2969429569 title "Characterization of a Linezolid- and Vancomycin-Resistant Streptococcus suis Isolate That Harbors optrA and vanG Operons" @default.
- W2969429569 cites W1595816437 @default.
- W2969429569 cites W1672739008 @default.
- W2969429569 cites W1867071170 @default.
- W2969429569 cites W1896505708 @default.
- W2969429569 cites W1969042907 @default.
- W2969429569 cites W1977069647 @default.
- W2969429569 cites W1982307880 @default.
- W2969429569 cites W1996405173 @default.
- W2969429569 cites W1998483495 @default.
- W2969429569 cites W2013102644 @default.
- W2969429569 cites W2013206472 @default.
- W2969429569 cites W2017685533 @default.
- W2969429569 cites W2019887475 @default.
- W2969429569 cites W2036424058 @default.
- W2969429569 cites W2040630478 @default.
- W2969429569 cites W2048272951 @default.
- W2969429569 cites W2065763760 @default.
- W2969429569 cites W2067910615 @default.
- W2969429569 cites W2072624994 @default.
- W2969429569 cites W2072764420 @default.
- W2969429569 cites W2093819664 @default.
- W2969429569 cites W2096174565 @default.
- W2969429569 cites W2097517770 @default.
- W2969429569 cites W2101571099 @default.
- W2969429569 cites W2101798664 @default.
- W2969429569 cites W2105047060 @default.
- W2969429569 cites W2107965209 @default.
- W2969429569 cites W2111211467 @default.
- W2969429569 cites W2115018455 @default.
- W2969429569 cites W2116764760 @default.
- W2969429569 cites W2121008200 @default.
- W2969429569 cites W2128715915 @default.
- W2969429569 cites W2133719033 @default.
- W2969429569 cites W2134214056 @default.
- W2969429569 cites W2134592715 @default.
- W2969429569 cites W2134852597 @default.
- W2969429569 cites W2136341799 @default.
- W2969429569 cites W2137610450 @default.
- W2969429569 cites W2139081288 @default.
- W2969429569 cites W2139760555 @default.
- W2969429569 cites W2142362917 @default.
- W2969429569 cites W2146438933 @default.
- W2969429569 cites W2148204140 @default.
- W2969429569 cites W2151329275 @default.
- W2969429569 cites W2154131559 @default.
- W2969429569 cites W2156208497 @default.
- W2969429569 cites W2169542398 @default.
- W2969429569 cites W2171235546 @default.
- W2969429569 cites W2171437337 @default.
- W2969429569 cites W2256756668 @default.
- W2969429569 cites W2261944450 @default.
- W2969429569 cites W2266847274 @default.
- W2969429569 cites W2279892490 @default.
- W2969429569 cites W2298195942 @default.
- W2969429569 cites W2339423458 @default.
- W2969429569 cites W2411571946 @default.
- W2969429569 cites W2493478985 @default.
- W2969429569 cites W2522178814 @default.
- W2969429569 cites W2524918985 @default.
- W2969429569 cites W2528742142 @default.
- W2969429569 cites W2536702949 @default.
- W2969429569 cites W2565406312 @default.
- W2969429569 cites W2591030241 @default.
- W2969429569 cites W2711683395 @default.
- W2969429569 cites W2759133728 @default.
- W2969429569 cites W2783616755 @default.
- W2969429569 cites W2795618605 @default.
- W2969429569 cites W2883675456 @default.
- W2969429569 cites W2898922831 @default.
- W2969429569 cites W2905061761 @default.
- W2969429569 cites W2910417921 @default.
- W2969429569 cites W2925648552 @default.
- W2969429569 cites W2938545938 @default.
- W2969429569 cites W2945107275 @default.
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- W2969429569 doi "https://doi.org/10.3389/fmicb.2019.02026" @default.
- W2969429569 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6746840" @default.
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- W2969429569 hasPublicationYear "2019" @default.
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