Matches in SemOpenAlex for { <https://semopenalex.org/work/W2969432783> ?p ?o ?g. }
- W2969432783 endingPage "329" @default.
- W2969432783 startingPage "329" @default.
- W2969432783 abstract "Leaf extract of Nelumbo nucifera (NLE) has been demonstrated to possess anti-atherosclerosis, improve alcohol-induced steatohepatitis, prevent high-fat diet-induced obesity, and inhibit the proliferation and metastasis of human breast cancer cells. This study determines the chemopreventive role of NLE against 2-acetylaminofluorene (AAF)-induced hepatocellular carcinoma (HCC) in rats. AAF was used to induce hepatocarcinogenesis in rats through genetic and nongenetic effects. After administration for 12 weeks, NLE (0.5–2%) supplementation orally inhibited AAF (0.03%)-induced hepatic fibrosis which appears during the development of premalignant lesions in rats. After the 6-month experiment, NLE supplementation resulted in decreasing AAF-induced serum parameters of hepatic injury, including the level of triglycerides, total cholesterol, alpha-fetoprotein (AFP), and inflammatory mediator interleukin (IL)-6 and tumor necrosis factor (TNF)-α as well as the activities of alanine aminotransferase (ALT), aspartate aminotransferase (AST), and gamma-glutamyl transferase (γGT). NLE supplementation also reduced AAF-induced lipid peroxidation and 8-hydroxy-2′-deoxyguanosine (8-OHdG) formation in the rat liver. Hepatic histopathological investigation revealed that NLE supplementation attenuated the AAF-induced HCC and glutathione S-transferase-Pi (GST-Pi) expression. Furthermore, NLE supplementation increased the expression of transcription factor, nuclear factor erythroid 2-related factor 2 (Nrf2) and its downstream targets, including catalase, glutathion peroxidase (GPx), and superoxide dismutase 1 (SOD-1) in the rat liver. Our findings indicate that NLE supplementation inhibited AAF-induced hepatocarcinogenesis by enhancing antioxidative potential and alleviating inflammation in rats." @default.
- W2969432783 created "2019-08-29" @default.
- W2969432783 creator A5004884157 @default.
- W2969432783 creator A5014290408 @default.
- W2969432783 creator A5074105906 @default.
- W2969432783 creator A5077059988 @default.
- W2969432783 date "2019-08-22" @default.
- W2969432783 modified "2023-09-27" @default.
- W2969432783 title "Inhibitory Effect of Nelumbo nucifera Leaf Extract on 2-Acetylaminofluorene-induced Hepatocarcinogenesis Through Enhancing Antioxidative Potential and Alleviating Inflammation in Rats" @default.
- W2969432783 cites W183162221 @default.
- W2969432783 cites W191793640 @default.
- W2969432783 cites W1964918914 @default.
- W2969432783 cites W1966940529 @default.
- W2969432783 cites W1975980695 @default.
- W2969432783 cites W1983310681 @default.
- W2969432783 cites W1986072191 @default.
- W2969432783 cites W1986572411 @default.
- W2969432783 cites W1994051836 @default.
- W2969432783 cites W1998748634 @default.
- W2969432783 cites W2001959193 @default.
- W2969432783 cites W2014182893 @default.
- W2969432783 cites W2015789993 @default.
- W2969432783 cites W2021677304 @default.
- W2969432783 cites W2024184602 @default.
- W2969432783 cites W2025877074 @default.
- W2969432783 cites W2027968437 @default.
- W2969432783 cites W2032938710 @default.
- W2969432783 cites W2035675168 @default.
- W2969432783 cites W2035873863 @default.
- W2969432783 cites W2038771381 @default.
- W2969432783 cites W2044665381 @default.
- W2969432783 cites W2051300948 @default.
- W2969432783 cites W2068149517 @default.
- W2969432783 cites W2081272995 @default.
- W2969432783 cites W2088866343 @default.
- W2969432783 cites W2099069896 @default.
- W2969432783 cites W2154239359 @default.
- W2969432783 cites W2357965555 @default.
- W2969432783 cites W2541410040 @default.
- W2969432783 cites W2625594257 @default.
- W2969432783 cites W2728933498 @default.
- W2969432783 cites W2737134798 @default.
- W2969432783 cites W2784772388 @default.
- W2969432783 cites W2807378628 @default.
- W2969432783 cites W2897557611 @default.
- W2969432783 cites W2914994738 @default.
- W2969432783 cites W78741705 @default.
- W2969432783 cites W79564423 @default.
- W2969432783 doi "https://doi.org/10.3390/antiox8090329" @default.
- W2969432783 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6770729" @default.
- W2969432783 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31443426" @default.
- W2969432783 hasPublicationYear "2019" @default.
- W2969432783 type Work @default.
- W2969432783 sameAs 2969432783 @default.
- W2969432783 citedByCount "11" @default.
- W2969432783 countsByYear W29694327832020 @default.
- W2969432783 countsByYear W29694327832021 @default.
- W2969432783 countsByYear W29694327832022 @default.
- W2969432783 crossrefType "journal-article" @default.
- W2969432783 hasAuthorship W2969432783A5004884157 @default.
- W2969432783 hasAuthorship W2969432783A5014290408 @default.
- W2969432783 hasAuthorship W2969432783A5074105906 @default.
- W2969432783 hasAuthorship W2969432783A5077059988 @default.
- W2969432783 hasBestOaLocation W29694327831 @default.
- W2969432783 hasConcept C126322002 @default.
- W2969432783 hasConcept C134018914 @default.
- W2969432783 hasConcept C185592680 @default.
- W2969432783 hasConcept C2775838275 @default.
- W2969432783 hasConcept C2776151105 @default.
- W2969432783 hasConcept C2776637226 @default.
- W2969432783 hasConcept C2776914184 @default.
- W2969432783 hasConcept C2778019345 @default.
- W2969432783 hasConcept C2778760513 @default.
- W2969432783 hasConcept C2778772119 @default.
- W2969432783 hasConcept C2779134260 @default.
- W2969432783 hasConcept C2779478299 @default.
- W2969432783 hasConcept C2780829032 @default.
- W2969432783 hasConcept C71924100 @default.
- W2969432783 hasConcept C86803240 @default.
- W2969432783 hasConcept C98274493 @default.
- W2969432783 hasConceptScore W2969432783C126322002 @default.
- W2969432783 hasConceptScore W2969432783C134018914 @default.
- W2969432783 hasConceptScore W2969432783C185592680 @default.
- W2969432783 hasConceptScore W2969432783C2775838275 @default.
- W2969432783 hasConceptScore W2969432783C2776151105 @default.
- W2969432783 hasConceptScore W2969432783C2776637226 @default.
- W2969432783 hasConceptScore W2969432783C2776914184 @default.
- W2969432783 hasConceptScore W2969432783C2778019345 @default.
- W2969432783 hasConceptScore W2969432783C2778760513 @default.
- W2969432783 hasConceptScore W2969432783C2778772119 @default.
- W2969432783 hasConceptScore W2969432783C2779134260 @default.
- W2969432783 hasConceptScore W2969432783C2779478299 @default.
- W2969432783 hasConceptScore W2969432783C2780829032 @default.
- W2969432783 hasConceptScore W2969432783C71924100 @default.
- W2969432783 hasConceptScore W2969432783C86803240 @default.
- W2969432783 hasConceptScore W2969432783C98274493 @default.
- W2969432783 hasIssue "9" @default.
- W2969432783 hasLocation W29694327831 @default.