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• W2969439652 endingPage "111641" @default.
• W2969439652 startingPage "111641" @default.
• W2969439652 abstract "The prevalence of diabetes has increased rapidly in the world. Chronic hyperglycemia is associated with the complications of diabetes and is a major problem for medicine. The present study aimed to explore the antidiabetic potential of the leaves of Cassia bakeriana Craib (family Leguminosae) by evaluating the antioxidant activity and inhibition of α-amylase, α-glucosidase, lipase and glycation activities, in addition to determining the chemical constituents of the most active fractions. Therefore, the n-hexane extract (HE) and the ethanolic extract (EE) of the leaves were prepared by maceration, and the fractions were obtained by liquid-liquid extraction. The EE of C. bakeriana and its fractions showed high antioxidant activity in the oxygen radical absorbance capacity (ORAC) assay, being superior to the positive control (ascorbic acid). In the 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay, the n-butanol fraction (BF) and ethyl acetate fraction (EAF) presented the best results. The EE showed higher inhibition of α-amylase activity (IC50 = 5.00 ± 0.85 μg mL−1) followed by EAF and BF. DF was the most active in the inhibition of α-glucosidase activity (IC50 = 359.55 ± 2.90 μg mL−1). The HE showed high inhibition of pancreatic lipase activity (IC50 = 25.27 ± 8.78 μg mL−1) and dichloromethane fraction (DF) and EAF were the most active inhibitors of glycation (IC50 = 37.85 ± 0.49 and 53.25 ± 11.24 μg mL−1, respectively). The fractionation of DF by semi-preparative HPLC-DAD led to the isolation of flavonoids: kaempferol-3-O-rhamnoside (I) and kaempferol (II), which were characterized by NMR and HPLC-ESI-MS. These compounds showed antioxidant activity in the ORAC method, but only compound II was active in the DPPH method. The isolated kaempferol (II) showed inhibitory activity against α-amylase (IC50 = 1.5 ± 0.14 μg mL−1). The compounds I and II showed inhibition of glycation (IC50 = 84.27 ± 11.38 and 64.16 ± 1.53 μg mL−1, respectively). Through the HPLC-ESI-MS analysis of the EE, DF and EAF, it was possible to propose the identification of some compounds such as acid phenolics, flavonoids, megastigmane, fatty acids and derivatives, sphingolipids, proanthocyanidins, cyanidin and anthraquinone." @default.
• W2969439652 created "2019-08-29" @default.
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• W2969439652 date "2019-11-01" @default.
• W2969439652 modified "2023-10-17" @default.
• W2969439652 title "Chemical composition, antioxidant activity and inhibitory capacity of α-amylase, α-glucosidase, lipase and non-enzymatic glycation, in vitro, of the leaves of Cassia bakeriana Craib" @default.
• W2969439652 cites W1589514561 @default.
• W2969439652 cites W1870696988 @default.
• W2969439652 cites W1903078185 @default.
• W2969439652 cites W19306959 @default.
• W2969439652 cites W1964623470 @default.
• W2969439652 cites W1967970452 @default.
• W2969439652 cites W1970187671 @default.
• W2969439652 cites W1971889786 @default.
• W2969439652 cites W1978759852 @default.
• W2969439652 cites W1981035084 @default.
• W2969439652 cites W1981725201 @default.
• W2969439652 cites W1984172052 @default.
• W2969439652 cites W1985055110 @default.
• W2969439652 cites W1989260895 @default.
• W2969439652 cites W1989421955 @default.
• W2969439652 cites W1990657948 @default.
• W2969439652 cites W1992703365 @default.
• W2969439652 cites W1992725304 @default.
• W2969439652 cites W1996122122 @default.
• W2969439652 cites W1998422123 @default.
• W2969439652 cites W1998560276 @default.
• W2969439652 cites W1999647730 @default.
• W2969439652 cites W2000235854 @default.
• W2969439652 cites W2003848126 @default.
• W2969439652 cites W2005670601 @default.
• W2969439652 cites W2005706383 @default.
• W2969439652 cites W2009253660 @default.
• W2969439652 cites W2014555762 @default.
• W2969439652 cites W2014558733 @default.
• W2969439652 cites W2014832907 @default.
• W2969439652 cites W2015801271 @default.
• W2969439652 cites W2017555955 @default.
• W2969439652 cites W2019935542 @default.
• W2969439652 cites W2022132995 @default.
• W2969439652 cites W2025447674 @default.
• W2969439652 cites W2025499590 @default.
• W2969439652 cites W2029388843 @default.
• W2969439652 cites W2029397926 @default.
• W2969439652 cites W2037789104 @default.
• W2969439652 cites W2038961236 @default.
• W2969439652 cites W2042494227 @default.
• W2969439652 cites W2043164308 @default.
• W2969439652 cites W2050693908 @default.
• W2969439652 cites W2052330771 @default.
• W2969439652 cites W2054433034 @default.
• W2969439652 cites W2054476524 @default.
• W2969439652 cites W2066164553 @default.
• W2969439652 cites W2075385383 @default.
• W2969439652 cites W2077675706 @default.
• W2969439652 cites W2079165366 @default.
• W2969439652 cites W2084132249 @default.
• W2969439652 cites W2088217253 @default.
• W2969439652 cites W2094199404 @default.
• W2969439652 cites W2097815597 @default.
• W2969439652 cites W2098153147 @default.
• W2969439652 cites W2098278612 @default.
• W2969439652 cites W2098429260 @default.
• W2969439652 cites W2100383726 @default.
• W2969439652 cites W2116946345 @default.
• W2969439652 cites W2119040924 @default.
• W2969439652 cites W2123033247 @default.
• W2969439652 cites W2132738767 @default.
• W2969439652 cites W2148334006 @default.
• W2969439652 cites W2149380324 @default.
• W2969439652 cites W2152398061 @default.
• W2969439652 cites W2152501542 @default.
• W2969439652 cites W2152720016 @default.
• W2969439652 cites W2157265873 @default.
• W2969439652 cites W2159009422 @default.
• W2969439652 cites W2166690382 @default.
• W2969439652 cites W2167543749 @default.
• W2969439652 cites W2188978555 @default.
• W2969439652 cites W2206228964 @default.
• W2969439652 cites W2220805110 @default.
• W2969439652 cites W2253990060 @default.
• W2969439652 cites W2256742438 @default.
• W2969439652 cites W2290501725 @default.
• W2969439652 cites W2338775652 @default.
• W2969439652 cites W2344884183 @default.
• W2969439652 cites W2439765084 @default.
• W2969439652 cites W2470153321 @default.

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