FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2969444097> ?p ?o ?g. }

• W2969444097 abstract "Objective: Characterize the clinical features and outcomes of primary and secondary gliosarcoma (PGS, SGS) at the National Cancer Institute Background: Gliosarcomas are considered rare variants of glioblastoma characterized by the presence of biphasic glial and mesenchymal components. PGS is defined as arising de novo in contrast to SGS where the sarcoma component is noted at recurrence of an established glioblastoma. This study examined the clinical features and outcomes comparing PGS with SGS. Design/Methods: An IRB approved NCI protocol was used to identify all patients with pathologically confirmed diagnosis of gliosarcoma and record clinical and outcomes data. Results: We identified 28 patients with PGS and 15 patients with SGS. Sex ratio (male to female) was 2.1 for PGS and 0.9 for SGS, with a median age of 53 years in each group. Only 1 patient with SGS had a history of brain irradiation before the diagnosis of glioblastoma. The common sites for tumor location were frontal (36%), bi-lobar (36%) and temporal (21%) for PGS and parietal (40%), frontal (20%) and temporal (20%) for SGS. Two patients with PGS (7%) developed extra-cranial metastasis (spinal cord and metastatic angiosarcoma). The median overall survival for PGS was 17.2 months compared with 30 months for SGS from initial diagnosis of high-grade glioma (HGG) (p=0.049). Median progression-free survival was 5.9 months for PGS and 9.7 months for SGS, from the diagnosis of HGG with a median from the time of sarcomatous transformation of 4.6 months. Conclusions: These findings suggest that there may be a difference in the underlying tumor biology between PGS and SGS but that the presence of a sarcomatous component, either at diagnosis or with subsequent transformation may lead to a treatment refractory and aggressive cancer. To further elucidate the biologic differences between SGS and PGS, RNA sequencing studies are underway. Disclosure: Dr. Ranjan has nothing to disclose. Dr. Colwell has nothing to disclose. Dr. Gilbert has nothing to disclose. Dr. Park has nothing to disclose." @default.
• W2969444097 created "2019-08-29" @default.
• W2969444097 creator A5006062173 @default.
• W2969444097 creator A5061314376 @default.
• W2969444097 creator A5064627876 @default.
• W2969444097 creator A5091017280 @default.
• W2969444097 date "2017-04-18" @default.
• W2969444097 modified "2023-09-23" @default.
• W2969444097 title "Primary and secondary gliosarcomas: clinical profile and outcomes at the National Cancer Institute (P5.163)" @default.
• W2969444097 hasPublicationYear "2017" @default.
• W2969444097 type Work @default.
• W2969444097 sameAs 2969444097 @default.
• W2969444097 citedByCount "0" @default.
• W2969444097 crossrefType "journal-article" @default.
• W2969444097 hasAuthorship W2969444097A5006062173 @default.
• W2969444097 hasAuthorship W2969444097A5061314376 @default.
• W2969444097 hasAuthorship W2969444097A5064627876 @default.
• W2969444097 hasAuthorship W2969444097A5091017280 @default.
• W2969444097 hasConcept C121608353 @default.
• W2969444097 hasConcept C126322002 @default.
• W2969444097 hasConcept C142724271 @default.
• W2969444097 hasConcept C143998085 @default.
• W2969444097 hasConcept C2777295375 @default.
• W2969444097 hasConcept C2778227246 @default.
• W2969444097 hasConcept C2778256501 @default.
• W2969444097 hasConcept C2779217266 @default.
• W2969444097 hasConcept C502942594 @default.
• W2969444097 hasConcept C71924100 @default.
• W2969444097 hasConceptScore W2969444097C121608353 @default.
• W2969444097 hasConceptScore W2969444097C126322002 @default.
• W2969444097 hasConceptScore W2969444097C142724271 @default.
• W2969444097 hasConceptScore W2969444097C143998085 @default.
• W2969444097 hasConceptScore W2969444097C2777295375 @default.
• W2969444097 hasConceptScore W2969444097C2778227246 @default.
• W2969444097 hasConceptScore W2969444097C2778256501 @default.
• W2969444097 hasConceptScore W2969444097C2779217266 @default.
• W2969444097 hasConceptScore W2969444097C502942594 @default.
• W2969444097 hasConceptScore W2969444097C71924100 @default.
• W2969444097 hasOpenAccess W2969444097 @default.
• W2969444097 hasRelatedWork W1963845775 @default.
• W2969444097 hasRelatedWork W1972447512 @default.
• W2969444097 hasRelatedWork W2003697699 @default.
• W2969444097 hasRelatedWork W2006300529 @default.
• W2969444097 hasRelatedWork W2157747429 @default.
• W2969444097 hasRelatedWork W2168991081 @default.
• W2969444097 hasRelatedWork W2256845554 @default.
• W2969444097 hasRelatedWork W2278713426 @default.
• W2969444097 hasRelatedWork W2331351824 @default.
• W2969444097 hasRelatedWork W2395025560 @default.
• W2969444097 hasRelatedWork W2399966727 @default.
• W2969444097 hasRelatedWork W2404397468 @default.
• W2969444097 hasRelatedWork W2415876876 @default.
• W2969444097 hasRelatedWork W2422466133 @default.
• W2969444097 hasRelatedWork W2918179356 @default.
• W2969444097 hasRelatedWork W2989072515 @default.
• W2969444097 hasRelatedWork W2995781187 @default.
• W2969444097 hasRelatedWork W3004201410 @default.
• W2969444097 hasRelatedWork W3015830558 @default.
• W2969444097 hasRelatedWork W3111173295 @default.
• W2969444097 hasVolume "88" @default.
• W2969444097 isParatext "false" @default.
• W2969444097 isRetracted "false" @default.
• W2969444097 magId "2969444097" @default.
• W2969444097 workType "article" @default.