FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2969453015> ?p ?o ?g. }

• W2969453015 endingPage "1732" @default.
• W2969453015 startingPage "1721" @default.
• W2969453015 abstract "Non-small cell lung cancer (NSCLC) is a complex disease in need of new methods of therapeutic intervention. Recent interest has focused on using microRNAs (miRNAs) as a novel treatment method for various cancers. miRNAs negatively regulate gene expression post-transcriptionally, and have become attractive candidates for cancer treatment because they often simultaneously target multiple genes of similar biological function. One such miRNA is miR-146a-5p, which has been described as a tumor suppressive miRNA in NSCLC cell lines and tissues. In this study, we performed RNA-Sequencing (RNA-Seq) analysis following transfection of synthetic miR-146a-5p in an NSCLC cell line, A549, and validated our data with Gene Ontology and qRT-PCR analysis of known miR-146a-5p target genes. Our transcriptomic data revealed that miR-146a-5p exerts its tumor suppressive function beyond previously reported targeting of EGFR and NF-κB signaling. miR-146a-5p mimic transfection downregulated arachidonic acid metabolism genes, the RNA-binding protein HuR, and many HuR-stabilized pro-cancer mRNAs, including TGF-β, HIF-1α, and various cyclins. miR-146a-5p transfection also reduced expression and cellular release of the chemokine CCL2, and this effect was mediated through the 3ʹ untranslated region of its mRNA. Taken together, our work reveals that miR-146a-5p functions as a tumor suppressor in NSCLC by controlling various metabolic and signaling pathways through direct and indirect mechanisms." @default.
• W2969453015 created "2019-08-29" @default.
• W2969453015 creator A5034453343 @default.
• W2969453015 creator A5035785741 @default.
• W2969453015 creator A5065559632 @default.
• W2969453015 creator A5080203051 @default.
• W2969453015 creator A5084076710 @default.
• W2969453015 date "2019-08-23" @default.
• W2969453015 modified "2023-09-24" @default.
• W2969453015 title "Transcriptomic studies provide insights into the tumor suppressive role of miR-146a-5p in non-small cell lung cancer (NSCLC) cells" @default.
• W2969453015 cites W1637759799 @default.
• W2969453015 cites W1648301895 @default.
• W2969453015 cites W1819165858 @default.
• W2969453015 cites W1975159841 @default.
• W2969453015 cites W1982967230 @default.
• W2969453015 cites W1991153319 @default.
• W2969453015 cites W1991544505 @default.
• W2969453015 cites W1992696908 @default.
• W2969453015 cites W2007251599 @default.
• W2969453015 cites W2010907636 @default.
• W2969453015 cites W2032298477 @default.
• W2969453015 cites W2047713688 @default.
• W2969453015 cites W2050489269 @default.
• W2969453015 cites W2052580925 @default.
• W2969453015 cites W2054630268 @default.
• W2969453015 cites W2072378401 @default.
• W2969453015 cites W2085555782 @default.
• W2969453015 cites W2090742115 @default.
• W2969453015 cites W2096307493 @default.
• W2969453015 cites W2097079963 @default.
• W2969453015 cites W2102500432 @default.
• W2969453015 cites W2120015541 @default.
• W2969453015 cites W2126496132 @default.
• W2969453015 cites W2127658932 @default.
• W2969453015 cites W2150565546 @default.
• W2969453015 cites W2152045576 @default.
• W2969453015 cites W2153522091 @default.
• W2969453015 cites W2156414024 @default.
• W2969453015 cites W2162674813 @default.
• W2969453015 cites W2164840475 @default.
• W2969453015 cites W2168223870 @default.
• W2969453015 cites W2328453756 @default.
• W2969453015 cites W2472347062 @default.
• W2969453015 cites W2555854562 @default.
• W2969453015 cites W2615694525 @default.
• W2969453015 cites W2624827575 @default.
• W2969453015 cites W2750610314 @default.
• W2969453015 cites W2765219164 @default.
• W2969453015 cites W2804162972 @default.
• W2969453015 cites W2805395855 @default.
• W2969453015 cites W2889354839 @default.
• W2969453015 cites W2918086501 @default.
• W2969453015 cites W2925046543 @default.
• W2969453015 cites W4210582839 @default.
• W2969453015 cites W54801374 @default.
• W2969453015 doi "https://doi.org/10.1080/15476286.2019.1657351" @default.
• W2969453015 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6844565" @default.
• W2969453015 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31425002" @default.
• W2969453015 hasPublicationYear "2019" @default.
• W2969453015 type Work @default.
• W2969453015 sameAs 2969453015 @default.
• W2969453015 citedByCount "12" @default.
• W2969453015 countsByYear W29694530152020 @default.
• W2969453015 countsByYear W29694530152021 @default.
• W2969453015 countsByYear W29694530152022 @default.
• W2969453015 countsByYear W29694530152023 @default.
• W2969453015 crossrefType "journal-article" @default.
• W2969453015 hasAuthorship W2969453015A5034453343 @default.
• W2969453015 hasAuthorship W2969453015A5035785741 @default.
• W2969453015 hasAuthorship W2969453015A5065559632 @default.
• W2969453015 hasAuthorship W2969453015A5080203051 @default.
• W2969453015 hasAuthorship W2969453015A5084076710 @default.
• W2969453015 hasBestOaLocation W29694530151 @default.
• W2969453015 hasConcept C104317684 @default.
• W2969453015 hasConcept C121608353 @default.
• W2969453015 hasConcept C143998085 @default.
• W2969453015 hasConcept C145059251 @default.
• W2969453015 hasConcept C150194340 @default.
• W2969453015 hasConcept C162317418 @default.
• W2969453015 hasConcept C2776256026 @default.
• W2969453015 hasConcept C502942594 @default.
• W2969453015 hasConcept C54009773 @default.
• W2969453015 hasConcept C54355233 @default.
• W2969453015 hasConcept C71924100 @default.
• W2969453015 hasConcept C86803240 @default.
• W2969453015 hasConceptScore W2969453015C104317684 @default.
• W2969453015 hasConceptScore W2969453015C121608353 @default.
• W2969453015 hasConceptScore W2969453015C143998085 @default.
• W2969453015 hasConceptScore W2969453015C145059251 @default.
• W2969453015 hasConceptScore W2969453015C150194340 @default.
• W2969453015 hasConceptScore W2969453015C162317418 @default.
• W2969453015 hasConceptScore W2969453015C2776256026 @default.
• W2969453015 hasConceptScore W2969453015C502942594 @default.
• W2969453015 hasConceptScore W2969453015C54009773 @default.
• W2969453015 hasConceptScore W2969453015C54355233 @default.
• W2969453015 hasConceptScore W2969453015C71924100 @default.
• W2969453015 hasConceptScore W2969453015C86803240 @default.
• W2969453015 hasIssue "12" @default.

• next