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- W2969463775 abstract "The potential application of high-efficiency luminescent materials with aggregation-induced emission (AIE) behaviour for central nervous system functional imaging is a promising emerging field of research. Whereas, their brain penetration and actual blood-brain barrier crossing mechanism remained scarcely understood. Herein, we report three D-π-A chromophores (DCO1-3) with AIE characteristics and two-photon activities. In particular, one of the compounds DCO3 displays large two-photon absorption cross-sections of up to 880 GM with 90% water fraction (fw). Meanwhile, introduced polyether chains endow them with appropriate biocompatibility and potential for central nervous system targeting. Its blood-brain barrier (BBB) penetration capability was evaluated in the cell model, indicating promising transcytosis efficiency via microtubule trafficking. The results offer a comprehensive understanding of designing AIE fluorescent probes for further central nervous system transportation and imaging purpose." @default.
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- W2969463775 date "2020-01-01" @default.
- W2969463775 modified "2023-10-16" @default.
- W2969463775 title "Aggregation-induced emission with enhanced two-photon absorption of dicyanomethylene-benzopyran with polyether chain for blood-brain barrier penetration" @default.
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- W2969463775 doi "https://doi.org/10.1016/j.dyepig.2019.107827" @default.
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