Matches in SemOpenAlex for { <https://semopenalex.org/work/W2969479909> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W2969479909 endingPage "S49" @default.
- W2969479909 startingPage "S49" @default.
- W2969479909 abstract "As with most cancer types, there remains a subset of B-cell acute lymphoblastic leukaemia (B-ALL) patients who will relapse and succumb to therapy-resistant disease. It is believed that tumour heterogeneity underpins therapy failure leading to a Darwinian model of clonal evolution, however, such studies do not account for the role of the bone marrow microenvironment in supporting leukaemia survival, progression and escape from treatment. Here, we perform single-cell RNA-Sequencing (scRNA-Seq) to generate a comprehensive map of the primary human B-ALL bone marrow immune microenvironment throughout three distinct stages of the human leukemic disease process: diagnosis, remission and relapse. These studies show extensive re-modelling of the immune microenvironment composition and cell-to-cell interactions throughout the course conventional chemotherapy, and uncover a role for inflammatory leukaemia-associated monocytes in promoting B-ALL pathogenesis in vivo. These monocytic subsets are predictive of Ph+ B-ALL patient event-free survival and when targeted in B-ALL animal models, lead to prolonged disease remission. Our profiling of the human B-ALL bone marrow immune microenvironment provides a greater understanding of the potential extrinsic regulators of B-ALL survival and may highlight previously unknown environmental factors influencing immune-based treatment approaches to high-risk B-ALL." @default.
- W2969479909 created "2019-08-29" @default.
- W2969479909 creator A5005001049 @default.
- W2969479909 creator A5018407483 @default.
- W2969479909 creator A5030223113 @default.
- W2969479909 creator A5039371995 @default.
- W2969479909 creator A5043455810 @default.
- W2969479909 creator A5046212168 @default.
- W2969479909 creator A5048744038 @default.
- W2969479909 creator A5051845185 @default.
- W2969479909 creator A5076989555 @default.
- W2969479909 creator A5080485119 @default.
- W2969479909 creator A5083455722 @default.
- W2969479909 creator A5084923564 @default.
- W2969479909 date "2019-08-01" @default.
- W2969479909 modified "2023-10-16" @default.
- W2969479909 title "2029 - THE RELAPSED B-CELL ACUTE LYMPHOBLASTIC LEUKAEMIA IMMUNE MICROENVIRONMENT" @default.
- W2969479909 doi "https://doi.org/10.1016/j.exphem.2019.06.301" @default.
- W2969479909 hasPublicationYear "2019" @default.
- W2969479909 type Work @default.
- W2969479909 sameAs 2969479909 @default.
- W2969479909 citedByCount "0" @default.
- W2969479909 crossrefType "journal-article" @default.
- W2969479909 hasAuthorship W2969479909A5005001049 @default.
- W2969479909 hasAuthorship W2969479909A5018407483 @default.
- W2969479909 hasAuthorship W2969479909A5030223113 @default.
- W2969479909 hasAuthorship W2969479909A5039371995 @default.
- W2969479909 hasAuthorship W2969479909A5043455810 @default.
- W2969479909 hasAuthorship W2969479909A5046212168 @default.
- W2969479909 hasAuthorship W2969479909A5048744038 @default.
- W2969479909 hasAuthorship W2969479909A5051845185 @default.
- W2969479909 hasAuthorship W2969479909A5076989555 @default.
- W2969479909 hasAuthorship W2969479909A5080485119 @default.
- W2969479909 hasAuthorship W2969479909A5083455722 @default.
- W2969479909 hasAuthorship W2969479909A5084923564 @default.
- W2969479909 hasBestOaLocation W29694799091 @default.
- W2969479909 hasConcept C142724271 @default.
- W2969479909 hasConcept C159654299 @default.
- W2969479909 hasConcept C203014093 @default.
- W2969479909 hasConcept C2776107976 @default.
- W2969479909 hasConcept C2778453870 @default.
- W2969479909 hasConcept C2779134260 @default.
- W2969479909 hasConcept C2780007613 @default.
- W2969479909 hasConcept C502942594 @default.
- W2969479909 hasConcept C71924100 @default.
- W2969479909 hasConcept C86803240 @default.
- W2969479909 hasConcept C8891405 @default.
- W2969479909 hasConceptScore W2969479909C142724271 @default.
- W2969479909 hasConceptScore W2969479909C159654299 @default.
- W2969479909 hasConceptScore W2969479909C203014093 @default.
- W2969479909 hasConceptScore W2969479909C2776107976 @default.
- W2969479909 hasConceptScore W2969479909C2778453870 @default.
- W2969479909 hasConceptScore W2969479909C2779134260 @default.
- W2969479909 hasConceptScore W2969479909C2780007613 @default.
- W2969479909 hasConceptScore W2969479909C502942594 @default.
- W2969479909 hasConceptScore W2969479909C71924100 @default.
- W2969479909 hasConceptScore W2969479909C86803240 @default.
- W2969479909 hasConceptScore W2969479909C8891405 @default.
- W2969479909 hasLocation W29694799091 @default.
- W2969479909 hasOpenAccess W2969479909 @default.
- W2969479909 hasPrimaryLocation W29694799091 @default.
- W2969479909 hasRelatedWork W10455795 @default.
- W2969479909 hasRelatedWork W10768118 @default.
- W2969479909 hasRelatedWork W1395124 @default.
- W2969479909 hasRelatedWork W14038933 @default.
- W2969479909 hasRelatedWork W14337131 @default.
- W2969479909 hasRelatedWork W14584756 @default.
- W2969479909 hasRelatedWork W14743255 @default.
- W2969479909 hasRelatedWork W1741507 @default.
- W2969479909 hasRelatedWork W3886502 @default.
- W2969479909 hasRelatedWork W9095759 @default.
- W2969479909 hasVolume "76" @default.
- W2969479909 isParatext "false" @default.
- W2969479909 isRetracted "false" @default.
- W2969479909 magId "2969479909" @default.
- W2969479909 workType "article" @default.