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• W2969495174 abstract "Background and aims Few studies have assessed the effect of the NPY gene rs16147 variant on metabolic response following a dietary intervention. We evaluated the effect of rs16147 on body weight and biochemical changes after a high-protein/low-carbohydrate hypocaloric diet compared with a standard severe hypocaloric diet over 9 months. Materials and methods A population of 270 obese individuals was enrolled. At baseline, participants were randomly allocated to one of two hypocaloric diets, high protein (Diet HP) or standard (Diet S), for a period of 9 months. Results After both diets, all genotypes showed decreased body mass index, weight, fat mass, waist circumference, and leptin levels. Participants with the minor allele (A) assigned to the HP diet showed decreases in total cholesterol (−6.5 ± 4.8 vs 10.1 ± 4.1 mg/dL; p < 0.05), LDL cholesterol (−5.9 ± 3.8 vs 9.6 ± 2.4 mg/dL; p < 0.05), triglycerides (−1.0 ± 4.8 vs 16.2 ± 4.1 mg/dL; p < 0.05), insulin (−0.5 ± 2.8 vs 1.7 ± 2.1 UI/L; p < 0.05), HOMA–IR (−0.2 ± 2.1 vs 0.5 ± 2.0 units; p < 0.05), and CRP (−0.3 ± 0.4 vs 1.3 ± 0.2 mg/dL; p < 0.05). Participants with the minor allele assigned to diet S also showed decreases in total cholesterol (−6.1 ± 4.1 vs 14.4 ± 3.1 mg/dL; p < 0.05), LDL-cholesterol (−3.1 ± 2.8 vs 15.0 ± 3.1 mg/dL; p < 0.05), triglycerides (−6.9 ± 4.1 vs 13.2 ± 4.0 mg/dL; p < 0.05), insulin (−0.3 ± 2.1 vs. −1.2 ± 0.2 UI/L: p < 0.05), HOMA–IR (−0.3 ± 2.1 vs. −1.6 ± 1.1 units: p < 0.05), and CRP (−0.4 ± 0.1 vs 1.1 ± 0.2 mg/dL; p < 0.05). Conclusion In obese Caucasians, the presence of the A allele of the rs16147 genetic variant produces a better metabolic response that is secondary to weight loss with two different hypocaloric diets." @default.
• W2969495174 created "2019-08-29" @default.
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• W2969495174 date "2019-10-01" @default.
• W2969495174 modified "2023-10-04" @default.
• W2969495174 title "Different effects of high-protein/low-carbohydrate versus standard hypocaloric diet on insulin resistance and lipid profile: Role of rs16147 variant of neuropeptide Y" @default.
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• W2969495174 doi "https://doi.org/10.1016/j.diabres.2019.107825" @default.
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