FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2969498733> ?p ?o ?g. }

• W2969498733 endingPage "112171" @default.
• W2969498733 startingPage "112171" @default.
• W2969498733 abstract "Liu-Shen-Wan (LSW) is one of the popular over-the-counter drugs in Asia, which contains realgar (As4S4), used for the treatment of upper respiratory tract inflammation and skin infections. However, the safety and potential risk of this arsenic remain unknown.The aim of this study was to determine total arsenic in tissue and investigate effects of regular dose and overdose LSW exposure on rat liver.We used a target lipidomics approach to quantify inflammatory eicosanoids and employed ICP-MS to determine total arsenic in tissue.The results showed that oral administration of 8 and 40 mg/kg LSW (1 and 5 fold human-equivalent dose) induced light changes of liver lipidomic profile in rats, which was associated with anti-inflammatory function of LSW. In our recent report, we observed that 41 and 134 mg/kg realgar (40 and 132 fold human-equivalent dose) stimulated rat liver inflammation through up-regulation of pro-inflammatory LOX-derived, CYP-derived HETEs and COX-derived PGs. However, we found that LSW in the form of drug combination, containing 41 and 134 mg/kg realger, could not stimulate these similar inflammatory responses in rats, although the liver total arsenic levels of the realger and LSW groups were same.The downregulation of pro-inflammatory response showed that the LSW containing realger is safer than realger alone administrated to rats. These results suggested that Chinese medicines combination could reduce realgar-derived arsenic toxicity in rats." @default.
• W2969498733 created "2019-08-29" @default.
• W2969498733 creator A5001221452 @default.
• W2969498733 creator A5003537990 @default.
• W2969498733 creator A5019344890 @default.
• W2969498733 creator A5026839296 @default.
• W2969498733 creator A5037531901 @default.
• W2969498733 creator A5041615081 @default.
• W2969498733 creator A5048181201 @default.
• W2969498733 creator A5051147169 @default.
• W2969498733 creator A5052805211 @default.
• W2969498733 creator A5061234082 @default.
• W2969498733 creator A5064313538 @default.
• W2969498733 creator A5074790085 @default.
• W2969498733 creator A5080658884 @default.
• W2969498733 creator A5081814766 @default.
• W2969498733 creator A5089436966 @default.
• W2969498733 creator A5091443146 @default.
• W2969498733 date "2020-03-01" @default.
• W2969498733 modified "2023-10-16" @default.
• W2969498733 title "Target lipidomics approach to reveal the resolution of inflammation induced by Chinese medicine combination in Liu-Shen-Wan against realgar overexposure to rats" @default.
• W2969498733 cites W1966455505 @default.
• W2969498733 cites W1975175626 @default.
• W2969498733 cites W1988871656 @default.
• W2969498733 cites W2000731602 @default.
• W2969498733 cites W2008978067 @default.
• W2969498733 cites W2026426983 @default.
• W2969498733 cites W2040915552 @default.
• W2969498733 cites W2051818206 @default.
• W2969498733 cites W2066966820 @default.
• W2969498733 cites W2067666621 @default.
• W2969498733 cites W2106768039 @default.
• W2969498733 cites W2129776180 @default.
• W2969498733 cites W2236805708 @default.
• W2969498733 cites W2326809210 @default.
• W2969498733 cites W2338771488 @default.
• W2969498733 cites W2606390916 @default.
• W2969498733 cites W2735538746 @default.
• W2969498733 cites W2767586242 @default.
• W2969498733 cites W2886121361 @default.
• W2969498733 cites W2896700864 @default.
• W2969498733 cites W2912216805 @default.
• W2969498733 doi "https://doi.org/10.1016/j.jep.2019.112171" @default.
• W2969498733 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31442622" @default.
• W2969498733 hasPublicationYear "2020" @default.
• W2969498733 type Work @default.
• W2969498733 sameAs 2969498733 @default.
• W2969498733 citedByCount "10" @default.
• W2969498733 countsByYear W29694987332021 @default.
• W2969498733 countsByYear W29694987332022 @default.
• W2969498733 countsByYear W29694987332023 @default.
• W2969498733 crossrefType "journal-article" @default.
• W2969498733 hasAuthorship W2969498733A5001221452 @default.
• W2969498733 hasAuthorship W2969498733A5003537990 @default.
• W2969498733 hasAuthorship W2969498733A5019344890 @default.
• W2969498733 hasAuthorship W2969498733A5026839296 @default.
• W2969498733 hasAuthorship W2969498733A5037531901 @default.
• W2969498733 hasAuthorship W2969498733A5041615081 @default.
• W2969498733 hasAuthorship W2969498733A5048181201 @default.
• W2969498733 hasAuthorship W2969498733A5051147169 @default.
• W2969498733 hasAuthorship W2969498733A5052805211 @default.
• W2969498733 hasAuthorship W2969498733A5061234082 @default.
• W2969498733 hasAuthorship W2969498733A5064313538 @default.
• W2969498733 hasAuthorship W2969498733A5074790085 @default.
• W2969498733 hasAuthorship W2969498733A5080658884 @default.
• W2969498733 hasAuthorship W2969498733A5081814766 @default.
• W2969498733 hasAuthorship W2969498733A5089436966 @default.
• W2969498733 hasAuthorship W2969498733A5091443146 @default.
• W2969498733 hasConcept C104317684 @default.
• W2969498733 hasConcept C126322002 @default.
• W2969498733 hasConcept C127561419 @default.
• W2969498733 hasConcept C178790620 @default.
• W2969498733 hasConcept C185592680 @default.
• W2969498733 hasConcept C203014093 @default.
• W2969498733 hasConcept C2776914184 @default.
• W2969498733 hasConcept C2777056448 @default.
• W2969498733 hasConcept C2778548315 @default.
• W2969498733 hasConcept C29730261 @default.
• W2969498733 hasConcept C502230775 @default.
• W2969498733 hasConcept C55493867 @default.
• W2969498733 hasConcept C556039675 @default.
• W2969498733 hasConcept C58017582 @default.
• W2969498733 hasConcept C71924100 @default.
• W2969498733 hasConcept C98274493 @default.
• W2969498733 hasConceptScore W2969498733C104317684 @default.
• W2969498733 hasConceptScore W2969498733C126322002 @default.
• W2969498733 hasConceptScore W2969498733C127561419 @default.
• W2969498733 hasConceptScore W2969498733C178790620 @default.
• W2969498733 hasConceptScore W2969498733C185592680 @default.
• W2969498733 hasConceptScore W2969498733C203014093 @default.
• W2969498733 hasConceptScore W2969498733C2776914184 @default.
• W2969498733 hasConceptScore W2969498733C2777056448 @default.
• W2969498733 hasConceptScore W2969498733C2778548315 @default.
• W2969498733 hasConceptScore W2969498733C29730261 @default.
• W2969498733 hasConceptScore W2969498733C502230775 @default.
• W2969498733 hasConceptScore W2969498733C55493867 @default.
• W2969498733 hasConceptScore W2969498733C556039675 @default.
• W2969498733 hasConceptScore W2969498733C58017582 @default.

• next