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• W2969508735 abstract "Gliosis defined as reactive changes of resident glia is the primary response of the central nervous system (CNS) to trauma. The proliferation and fate controls of injury-reactivated glia are essential but remain largely unexplored. In zebrafish optic tectum, we found that stab injury drove a subset of radial glia (RG) into the cell cycle, and surprisingly, proliferative RG responding to sequential injuries of the same site were distinct but overlapping, which was in agreement with stochastic cell-cycle entry. Single-cell RNA sequencing analysis and functional assays further revealed the involvement of Notch/Delta lateral inhibition in this stochastic cell-cycle entry. Furthermore, the long-term clonal analysis showed that proliferative RG were largely gliogenic. Notch inhibition of reactive RG, not dormant and proliferative RG, resulted in an increased production of neurons, which were short-lived. Our findings gain new insights into the proliferation and fate controls of injury-reactivated CNS glia in zebrafish." @default.
• W2969508735 created "2019-08-29" @default.
• W2969508735 creator A5004307488 @default.
• W2969508735 creator A5039787951 @default.
• W2969508735 date "2019-08-23" @default.
• W2969508735 modified "2023-09-23" @default.
• W2969508735 title "Stochastic cell-cycle entry and cell-state-dependent fate outputs of injury-reactivated tectal radial glia in zebrafish" @default.
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• W2969508735 doi "https://doi.org/10.7554/elife.48660" @default.
• W2969508735 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6707787" @default.
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• W2969508735 hasPublicationYear "2019" @default.
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