Matches in SemOpenAlex for { <https://semopenalex.org/work/W2969514926> ?p ?o ?g. }
- W2969514926 endingPage "4161" @default.
- W2969514926 startingPage "4161" @default.
- W2969514926 abstract "Patients suffering from liver cirrhosis are often complicated with the formation of portosystemic collateral vessels, which is associated with the progression of a splanchnic hyperdynamic circulatory state. Alleviating pathological angiogenesis has thus been proposed to be a feasible treatment strategy. Indole-3-carbinol (C9H9NO, I3C) and 3,3'-diindolymethane (DIM), formed by the breakdown of glucosinolate glucobrassicin, are prevalent in cruciferous vegetables and have anti-angiogenesis properties. We aimed to evaluate their influences on portal hypertension, the severity of mesenteric angiogenesis, and portosystemic collaterals in cirrhosis. Sprague-Dawley rats with common bile duct ligation (CBDL)-induced liver cirrhosis or sham operation (surgical control) were randomly allocated to receive I3C (20 mg/kg/3 day), DIM (5 mg/kg/day) or vehicle for 28 days. The systemic and portal hemodynamics, severity of portosystemic shunting, mesenteric angiogenesis, and mesenteric proangiogenic factors protein expressions were evaluated. Compared to vehicle, both DIM and I3C significantly reduced portal pressure, ameliorated liver fibrosis, and down-regulated mesenteric protein expressions of vascular endothelial growth factor and phosphorylated Akt. DIM significantly down-regulated pErk, and I3C down-regulated NFκB, pIκBα protein expressions, and reduced portosystemic shunting degree. The cruciferous vegetable byproducts I3C and DIM not only exerted a portal hypotensive effect but also ameliorated abnormal angiogenesis and portosystemic collaterals in cirrhotic rats." @default.
- W2969514926 created "2019-08-29" @default.
- W2969514926 creator A5004513656 @default.
- W2969514926 creator A5015767105 @default.
- W2969514926 creator A5025153405 @default.
- W2969514926 creator A5029800309 @default.
- W2969514926 creator A5041600774 @default.
- W2969514926 creator A5049654357 @default.
- W2969514926 creator A5060283595 @default.
- W2969514926 creator A5064182782 @default.
- W2969514926 creator A5065216952 @default.
- W2969514926 creator A5089509231 @default.
- W2969514926 date "2019-08-26" @default.
- W2969514926 modified "2023-10-18" @default.
- W2969514926 title "Glucobrassicin Metabolites Ameliorate the Development of Portal Hypertension and Cirrhosis in Bile Duct-Ligated Rats" @default.
- W2969514926 cites W1601292221 @default.
- W2969514926 cites W1603929148 @default.
- W2969514926 cites W166448751 @default.
- W2969514926 cites W1674514490 @default.
- W2969514926 cites W1797076168 @default.
- W2969514926 cites W1848999321 @default.
- W2969514926 cites W1964005024 @default.
- W2969514926 cites W1968861450 @default.
- W2969514926 cites W1969989426 @default.
- W2969514926 cites W1986308750 @default.
- W2969514926 cites W1991058402 @default.
- W2969514926 cites W1991224459 @default.
- W2969514926 cites W1993316149 @default.
- W2969514926 cites W1994526215 @default.
- W2969514926 cites W1996745369 @default.
- W2969514926 cites W2003520246 @default.
- W2969514926 cites W2007864357 @default.
- W2969514926 cites W2010995196 @default.
- W2969514926 cites W2015505944 @default.
- W2969514926 cites W2023363105 @default.
- W2969514926 cites W2023596297 @default.
- W2969514926 cites W2025077770 @default.
- W2969514926 cites W2028204224 @default.
- W2969514926 cites W2039589111 @default.
- W2969514926 cites W2043620261 @default.
- W2969514926 cites W2050605694 @default.
- W2969514926 cites W2056694303 @default.
- W2969514926 cites W2062588262 @default.
- W2969514926 cites W2070612184 @default.
- W2969514926 cites W2074384261 @default.
- W2969514926 cites W2078083828 @default.
- W2969514926 cites W2081743448 @default.
- W2969514926 cites W2086057653 @default.
- W2969514926 cites W2091774189 @default.
- W2969514926 cites W2097445366 @default.
- W2969514926 cites W2100269181 @default.
- W2969514926 cites W2106984814 @default.
- W2969514926 cites W2107476734 @default.
- W2969514926 cites W2117725026 @default.
- W2969514926 cites W2126842347 @default.
- W2969514926 cites W2128635872 @default.
- W2969514926 cites W2136275747 @default.
- W2969514926 cites W2136601392 @default.
- W2969514926 cites W2146578343 @default.
- W2969514926 cites W2160056506 @default.
- W2969514926 cites W2162226128 @default.
- W2969514926 cites W2163752139 @default.
- W2969514926 cites W2163895012 @default.
- W2969514926 cites W2269904998 @default.
- W2969514926 cites W2384829073 @default.
- W2969514926 cites W2606927944 @default.
- W2969514926 cites W273038247 @default.
- W2969514926 cites W2773777274 @default.
- W2969514926 cites W2789696244 @default.
- W2969514926 cites W4293247451 @default.
- W2969514926 cites W2126802417 @default.
- W2969514926 doi "https://doi.org/10.3390/ijms20174161" @default.
- W2969514926 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6747388" @default.
- W2969514926 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31454890" @default.
- W2969514926 hasPublicationYear "2019" @default.
- W2969514926 type Work @default.
- W2969514926 sameAs 2969514926 @default.
- W2969514926 citedByCount "5" @default.
- W2969514926 countsByYear W29695149262021 @default.
- W2969514926 countsByYear W29695149262022 @default.
- W2969514926 countsByYear W29695149262023 @default.
- W2969514926 crossrefType "journal-article" @default.
- W2969514926 hasAuthorship W2969514926A5004513656 @default.
- W2969514926 hasAuthorship W2969514926A5015767105 @default.
- W2969514926 hasAuthorship W2969514926A5025153405 @default.
- W2969514926 hasAuthorship W2969514926A5029800309 @default.
- W2969514926 hasAuthorship W2969514926A5041600774 @default.
- W2969514926 hasAuthorship W2969514926A5049654357 @default.
- W2969514926 hasAuthorship W2969514926A5060283595 @default.
- W2969514926 hasAuthorship W2969514926A5064182782 @default.
- W2969514926 hasAuthorship W2969514926A5065216952 @default.
- W2969514926 hasAuthorship W2969514926A5089509231 @default.
- W2969514926 hasBestOaLocation W29695149261 @default.
- W2969514926 hasConcept C126322002 @default.
- W2969514926 hasConcept C134018914 @default.
- W2969514926 hasConcept C2777214474 @default.
- W2969514926 hasConcept C2778674827 @default.
- W2969514926 hasConcept C2778808290 @default.