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- W2969520380 endingPage "540" @default.
- W2969520380 startingPage "531" @default.
- W2969520380 abstract "The phenomenon of bacterial persistence, also known as non-inherited antibiotic tolerance in a part of bacterial populations, was described more than 70 years ago. This type of tolerance contributes to the chronization of infectious diseases, including tuberculosis. Currently, the emergence of persistent cells in bacterial populations is associated with the functioning of some stress-induced molecular triggers, including toxin-antitoxin systems. In the presented review, genetic and metabolic peculiarities of persistent cells are considered and the mechanisms of their occurrence are discussed. The hypothesis of the origin of persister cells based on bistability, arising due to the non-linear properties of a coupled transcription-translation system, was proposed. Within this hypothesis, the phenomenon of the bacterial persistence of modern cells is considered as a result of the genetic fixation of the phenotypic multiplicity that emerged in primitive cells in the process of neutrally coupled co-evolution (genetic drift of multiple neutrally coupled mutations). Our hypothesis explains the properties of persister cells, as well as their origin and ineradicable nature." @default.
- W2969520380 created "2019-08-29" @default.
- W2969520380 creator A5056460726 @default.
- W2969520380 creator A5091223474 @default.
- W2969520380 date "2019-01-01" @default.
- W2969520380 modified "2023-09-23" @default.
- W2969520380 title "Молекулярные механизмы ненаследуемой толерантности к антибиотикам у бактерий и архей" @default.
- W2969520380 cites W135230180 @default.
- W2969520380 cites W1482099685 @default.
- W2969520380 cites W1504663309 @default.
- W2969520380 cites W1515131566 @default.
- W2969520380 cites W1588664883 @default.
- W2969520380 cites W1604915411 @default.
- W2969520380 cites W1666867306 @default.
- W2969520380 cites W1691301065 @default.
- W2969520380 cites W170995186 @default.
- W2969520380 cites W1899580745 @default.
- W2969520380 cites W1934154653 @default.
- W2969520380 cites W1963674435 @default.
- W2969520380 cites W1968305507 @default.
- W2969520380 cites W1970661255 @default.
- W2969520380 cites W1976535961 @default.
- W2969520380 cites W1982958351 @default.
- W2969520380 cites W1983519005 @default.
- W2969520380 cites W1986602531 @default.
- W2969520380 cites W1987519818 @default.
- W2969520380 cites W1989355584 @default.
- W2969520380 cites W1992572387 @default.
- W2969520380 cites W1993351732 @default.
- W2969520380 cites W1996357994 @default.
- W2969520380 cites W1996890828 @default.
- W2969520380 cites W2003028136 @default.
- W2969520380 cites W2003324857 @default.
- W2969520380 cites W2007325254 @default.
- W2969520380 cites W2010912190 @default.
- W2969520380 cites W2013244831 @default.
- W2969520380 cites W2020176076 @default.
- W2969520380 cites W2030085942 @default.
- W2969520380 cites W2034738976 @default.
- W2969520380 cites W2041367172 @default.
- W2969520380 cites W2044079597 @default.
- W2969520380 cites W2045710759 @default.
- W2969520380 cites W2045825103 @default.
- W2969520380 cites W2057203470 @default.
- W2969520380 cites W2058212562 @default.
- W2969520380 cites W2058224146 @default.
- W2969520380 cites W2059049903 @default.
- W2969520380 cites W2060247350 @default.
- W2969520380 cites W2061385922 @default.
- W2969520380 cites W2064483836 @default.
- W2969520380 cites W2069488810 @default.
- W2969520380 cites W2069704172 @default.
- W2969520380 cites W2073824449 @default.
- W2969520380 cites W2074278080 @default.
- W2969520380 cites W2075023168 @default.
- W2969520380 cites W2075526709 @default.
- W2969520380 cites W2088171009 @default.
- W2969520380 cites W2090232842 @default.
- W2969520380 cites W2091198609 @default.
- W2969520380 cites W2096692298 @default.
- W2969520380 cites W2100053975 @default.
- W2969520380 cites W2103096980 @default.
- W2969520380 cites W2103584554 @default.
- W2969520380 cites W2106269045 @default.
- W2969520380 cites W2114537906 @default.
- W2969520380 cites W2115965551 @default.
- W2969520380 cites W2117597548 @default.
- W2969520380 cites W2118904810 @default.
- W2969520380 cites W2120545407 @default.
- W2969520380 cites W2123474506 @default.
- W2969520380 cites W2123880844 @default.
- W2969520380 cites W2125343967 @default.
- W2969520380 cites W2127817798 @default.
- W2969520380 cites W2127967394 @default.
- W2969520380 cites W2135133274 @default.
- W2969520380 cites W2141984091 @default.
- W2969520380 cites W2143842076 @default.
- W2969520380 cites W2145676608 @default.
- W2969520380 cites W2148323109 @default.
- W2969520380 cites W2153148799 @default.
- W2969520380 cites W2158296347 @default.
- W2969520380 cites W2160855410 @default.
- W2969520380 cites W2161251399 @default.
- W2969520380 cites W2161521198 @default.
- W2969520380 cites W2163876231 @default.
- W2969520380 cites W2168207658 @default.
- W2969520380 cites W2168606178 @default.
- W2969520380 cites W2171186968 @default.
- W2969520380 cites W2273414649 @default.
- W2969520380 cites W2278255289 @default.
- W2969520380 cites W2293483182 @default.
- W2969520380 cites W2336504120 @default.
- W2969520380 cites W2368099327 @default.
- W2969520380 cites W2399489368 @default.
- W2969520380 cites W2401079865 @default.
- W2969520380 cites W2418428478 @default.
- W2969520380 cites W2419091440 @default.
- W2969520380 cites W2523512393 @default.