Matches in SemOpenAlex for { <https://semopenalex.org/work/W2969565252> ?p ?o ?g. }
- W2969565252 endingPage "e16922" @default.
- W2969565252 startingPage "e16922" @default.
- W2969565252 abstract "Abstract Background: Circular RNAs (circRNAs) have displayed dysregulated expression in several types of cancer. Nevertheless, their function and underlying mechanisms in cervical cancer remains largely unknown. This study aimed to describe the regulatory mechanisms in cervical cancer. Methods: We downloaded the circRNAs expression profiles from Gene Expression Omnibus database, and RNAs expression profiles from The Cancer Genome Atlas database. We established a circRNA-miRNA-mRNA and circRNA-miRNA-hubgene network. The interactions between proteins were analyzed using the STRING database and hubgenes were identified using MCODE plugin. Then, we conducted a circRNA-miRNA-hubgenes regulatory module. Functional and pathway enrichment analyses were conducted using R packages “Clusterprofile”. Results: Six circRNAs, 15 miRNAs, and 158 mRNAs were identified to construct the ceRNA network of cervical cancer. PPI (protein-protein interaction) network and module analysis identified 7 hubgenes. Then, a circRNA-miRNA-hubgene subnetwork was constructed based on the 1 DEcircRNAs, 3 DEmiRNAs, and 3 DEmRNAs. The KEGG pathway analysis indicated DEmRNAs are involved in progesterone-mediated oocyte maturation, cell cycle, and oocyte meiosis. Conclusion: These ceRNAs are critical in the pathogenesis of cervical and may serve as future therapeutic biomarkers." @default.
- W2969565252 created "2019-08-29" @default.
- W2969565252 creator A5053921484 @default.
- W2969565252 creator A5054751043 @default.
- W2969565252 creator A5068952473 @default.
- W2969565252 creator A5070134243 @default.
- W2969565252 creator A5071375088 @default.
- W2969565252 creator A5079952159 @default.
- W2969565252 creator A5084200749 @default.
- W2969565252 creator A5084571872 @default.
- W2969565252 date "2019-08-01" @default.
- W2969565252 modified "2023-09-26" @default.
- W2969565252 title "Integrated analysis of circular RNA-associated ceRNA network in cervical cancer" @default.
- W2969565252 cites W158899354 @default.
- W2969565252 cites W1991082489 @default.
- W2969565252 cites W2035618305 @default.
- W2969565252 cites W2089080407 @default.
- W2969565252 cites W2106787323 @default.
- W2969565252 cites W2109923675 @default.
- W2969565252 cites W2123250471 @default.
- W2969565252 cites W2147806662 @default.
- W2969565252 cites W2160478953 @default.
- W2969565252 cites W2162674813 @default.
- W2969565252 cites W2276711938 @default.
- W2969565252 cites W2535025297 @default.
- W2969565252 cites W2560097351 @default.
- W2969565252 cites W2573929382 @default.
- W2969565252 cites W2582081818 @default.
- W2969565252 cites W2592206889 @default.
- W2969565252 cites W2729694525 @default.
- W2969565252 cites W2743678071 @default.
- W2969565252 cites W2755990621 @default.
- W2969565252 cites W2764294957 @default.
- W2969565252 cites W2781525129 @default.
- W2969565252 cites W2782434630 @default.
- W2969565252 cites W2795917193 @default.
- W2969565252 cites W2804622884 @default.
- W2969565252 cites W2884692871 @default.
- W2969565252 cites W2891685852 @default.
- W2969565252 cites W2892584113 @default.
- W2969565252 cites W2896377990 @default.
- W2969565252 cites W2896450901 @default.
- W2969565252 cites W2901528543 @default.
- W2969565252 cites W2902302216 @default.
- W2969565252 cites W2903579127 @default.
- W2969565252 cites W2905050494 @default.
- W2969565252 cites W2905533878 @default.
- W2969565252 cites W2905670158 @default.
- W2969565252 cites W2906102875 @default.
- W2969565252 cites W2906131344 @default.
- W2969565252 cites W2906753134 @default.
- W2969565252 cites W2907084168 @default.
- W2969565252 cites W2964277580 @default.
- W2969565252 cites W2982097294 @default.
- W2969565252 cites W3024713968 @default.
- W2969565252 cites W4211064852 @default.
- W2969565252 doi "https://doi.org/10.1097/md.0000000000016922" @default.
- W2969565252 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6716739" @default.
- W2969565252 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31441876" @default.
- W2969565252 hasPublicationYear "2019" @default.
- W2969565252 type Work @default.
- W2969565252 sameAs 2969565252 @default.
- W2969565252 citedByCount "25" @default.
- W2969565252 countsByYear W29695652522020 @default.
- W2969565252 countsByYear W29695652522021 @default.
- W2969565252 countsByYear W29695652522022 @default.
- W2969565252 countsByYear W29695652522023 @default.
- W2969565252 crossrefType "journal-article" @default.
- W2969565252 hasAuthorship W2969565252A5053921484 @default.
- W2969565252 hasAuthorship W2969565252A5054751043 @default.
- W2969565252 hasAuthorship W2969565252A5068952473 @default.
- W2969565252 hasAuthorship W2969565252A5070134243 @default.
- W2969565252 hasAuthorship W2969565252A5071375088 @default.
- W2969565252 hasAuthorship W2969565252A5079952159 @default.
- W2969565252 hasAuthorship W2969565252A5084200749 @default.
- W2969565252 hasAuthorship W2969565252A5084571872 @default.
- W2969565252 hasBestOaLocation W29695652521 @default.
- W2969565252 hasConcept C104317684 @default.
- W2969565252 hasConcept C121608353 @default.
- W2969565252 hasConcept C145059251 @default.
- W2969565252 hasConcept C150194340 @default.
- W2969565252 hasConcept C152724338 @default.
- W2969565252 hasConcept C162317418 @default.
- W2969565252 hasConcept C2775893923 @default.
- W2969565252 hasConcept C2778220009 @default.
- W2969565252 hasConcept C54355233 @default.
- W2969565252 hasConcept C60365752 @default.
- W2969565252 hasConcept C60644358 @default.
- W2969565252 hasConcept C62203573 @default.
- W2969565252 hasConcept C67705224 @default.
- W2969565252 hasConcept C70721500 @default.
- W2969565252 hasConcept C71924100 @default.
- W2969565252 hasConcept C86803240 @default.
- W2969565252 hasConceptScore W2969565252C104317684 @default.
- W2969565252 hasConceptScore W2969565252C121608353 @default.
- W2969565252 hasConceptScore W2969565252C145059251 @default.
- W2969565252 hasConceptScore W2969565252C150194340 @default.
- W2969565252 hasConceptScore W2969565252C152724338 @default.