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- W2969572877 abstract "The intestine-targeted delivery performance of the gum Arabic (GA) – O-carboxymethyl chitosan (OCMC) microcapsules prepared by layer-by-layer (LbL) assembly and genipin crosslinking was evaluated by using an acid-susceptible compound omeprazole as the model. Confocal laser scanning microscope observation revealed that spherical microcapsules with the core-shell structure were successful fabricated. Genipin crosslinking did not affect the microencapsulation yield or drug load, but significantly decreased the particle size and positive charge of the microcapsules, and increased their stability against disintegration in the simulated gastric fluid. Pharmacokinetic analysis indicated that entrapment by GA – OCMC LbL assembly greatly improved the bioavailability of omeprazole and crosslinking by 0.1 mg/mL genipin led to the highest value of 8.76 relative to the control formulation. It was concluded that the GA – OCMC LbL microcapsules could be used for the oral delivery of nutraceuticals and its delivery performance could be tailored by varying the genipin crosslinking degree." @default.
- W2969572877 created "2019-08-29" @default.
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- W2969572877 date "2019-12-01" @default.
- W2969572877 modified "2023-10-01" @default.
- W2969572877 title "Intestine-targeted delivery potency of O-carboxymethyl chitosan–coated layer-by-layer microcapsules: An in vitro and in vivo evaluation" @default.
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- W2969572877 doi "https://doi.org/10.1016/j.msec.2019.110129" @default.
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