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- W2969584990 endingPage "4092" @default.
- W2969584990 startingPage "4092" @default.
- W2969584990 abstract "The gut-derived incretin hormones glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) are secreted after meal ingestion and work in concert to promote postprandial insulin secretion. Furthermore, GLP-1 inhibits glucagon secretion when plasma glucose concentrations are above normal fasting concentrations while GIP acts glucagonotropically at low glucose levels. A dual incretin receptor agonist designed to co-activate GLP-1 and GIP receptors was recently shown to elicit robust improvements of glycemic control (mean haemoglobin A1c reduction of 1.94%) and massive body weight loss (mean weight loss of 11.3 kg) after 26 weeks of treatment with the highest dose (15 mg once weekly) in a clinical trial including overweight/obese patients with type 2 diabetes. Here, we describe the mechanisms by which the two incretins modulate alpha cell secretion of glucagon, review the effects of co-administration of GLP-1 and GIP on glucagon secretion, and discuss the potential role of glucagon in the therapeutic effects observed with novel unimolecular dual GLP-1/GIP receptor agonists. For clinicians and researchers, this manuscript offers an understanding of incretin physiology and pharmacology, and provides mechanistic insight into future antidiabetic and obesity treatments." @default.
- W2969584990 created "2019-08-29" @default.
- W2969584990 creator A5004120950 @default.
- W2969584990 creator A5035045477 @default.
- W2969584990 creator A5051382562 @default.
- W2969584990 creator A5060170508 @default.
- W2969584990 creator A5069729090 @default.
- W2969584990 creator A5071807773 @default.
- W2969584990 creator A5079352451 @default.
- W2969584990 date "2019-08-22" @default.
- W2969584990 modified "2023-10-18" @default.
- W2969584990 title "The Effects of Dual GLP-1/GIP Receptor Agonism on Glucagon Secretion—A Review" @default.
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