FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2969587497> ?p ?o ?g. }

• W2969587497 endingPage "673" @default.
• W2969587497 startingPage "656" @default.
• W2969587497 abstract "miRNAs can be found in serum and other body fluids and serve as biomarkers for disease. More importantly, secreted miRNAs, especially those in extracellular vesicles (EVs) such as exosomes, may mediate paracrine and endocrine communication between different tissues and thus modulate gene expression and the function of distal cells. When impaired, these processes can lead to tissue dysfunction, aging, and disease. Adipose tissue is an especially important contributor to the pool of circulating exosomal miRNAs. As a result, alterations in adipose tissue mass or function, which occur in many metabolic conditions, can lead to changes in circulating miRNAs, which then function systemically. Here we review the findings that led to these conclusions and discuss how this sets the stage for new lines of investigation in which extracellular miRNAs are recognized as important mediators of intercellular communication and potential candidates for therapy of disease. miRNAs can be found in serum and other body fluids and serve as biomarkers for disease. More importantly, secreted miRNAs, especially those in extracellular vesicles (EVs) such as exosomes, may mediate paracrine and endocrine communication between different tissues and thus modulate gene expression and the function of distal cells. When impaired, these processes can lead to tissue dysfunction, aging, and disease. Adipose tissue is an especially important contributor to the pool of circulating exosomal miRNAs. As a result, alterations in adipose tissue mass or function, which occur in many metabolic conditions, can lead to changes in circulating miRNAs, which then function systemically. Here we review the findings that led to these conclusions and discuss how this sets the stage for new lines of investigation in which extracellular miRNAs are recognized as important mediators of intercellular communication and potential candidates for therapy of disease." @default.
• W2969587497 created "2019-08-29" @default.
• W2969587497 creator A5024833627 @default.
• W2969587497 creator A5031778668 @default.
• W2969587497 creator A5049883349 @default.
• W2969587497 creator A5051737440 @default.
• W2969587497 creator A5091595811 @default.
• W2969587497 date "2019-10-01" @default.
• W2969587497 modified "2023-10-16" @default.
• W2969587497 title "Extracellular miRNAs: From Biomarkers to Mediators of Physiology and Disease" @default.
• W2969587497 cites W132194252 @default.
• W2969587497 cites W1494035906 @default.
• W2969587497 cites W1497459018 @default.
• W2969587497 cites W1533680245 @default.
• W2969587497 cites W1533774788 @default.
• W2969587497 cites W1538612491 @default.
• W2969587497 cites W1580551725 @default.
• W2969587497 cites W1634153319 @default.
• W2969587497 cites W1647788102 @default.
• W2969587497 cites W1852999829 @default.
• W2969587497 cites W1879956268 @default.
• W2969587497 cites W1956379561 @default.
• W2969587497 cites W1962838540 @default.
• W2969587497 cites W1965306643 @default.
• W2969587497 cites W1967896870 @default.
• W2969587497 cites W1968081342 @default.
• W2969587497 cites W1969863654 @default.
• W2969587497 cites W1971003548 @default.
• W2969587497 cites W1971764287 @default.
• W2969587497 cites W1972651881 @default.
• W2969587497 cites W1973876456 @default.
• W2969587497 cites W1974035668 @default.
• W2969587497 cites W1974997620 @default.
• W2969587497 cites W1975998449 @default.
• W2969587497 cites W1978171797 @default.
• W2969587497 cites W1979751563 @default.
• W2969587497 cites W1980888291 @default.
• W2969587497 cites W1985175917 @default.
• W2969587497 cites W1985844219 @default.
• W2969587497 cites W1987824810 @default.
• W2969587497 cites W1989146491 @default.
• W2969587497 cites W1991027071 @default.
• W2969587497 cites W1992342871 @default.
• W2969587497 cites W1992420161 @default.
• W2969587497 cites W1994344811 @default.
• W2969587497 cites W1996301440 @default.
• W2969587497 cites W1999732172 @default.
• W2969587497 cites W1999970685 @default.
• W2969587497 cites W2000156446 @default.
• W2969587497 cites W2001500692 @default.
• W2969587497 cites W2001790556 @default.
• W2969587497 cites W2002347168 @default.
• W2969587497 cites W2003206209 @default.
• W2969587497 cites W2003343932 @default.
• W2969587497 cites W2004280138 @default.
• W2969587497 cites W2004844217 @default.
• W2969587497 cites W2006247279 @default.
• W2969587497 cites W2006426795 @default.
• W2969587497 cites W2006986124 @default.
• W2969587497 cites W2007198184 @default.
• W2969587497 cites W2007381960 @default.
• W2969587497 cites W2010252233 @default.
• W2969587497 cites W2013868665 @default.
• W2969587497 cites W2018106032 @default.
• W2969587497 cites W2020268185 @default.
• W2969587497 cites W2024206172 @default.
• W2969587497 cites W2024704386 @default.
• W2969587497 cites W2026166033 @default.
• W2969587497 cites W2026991636 @default.
• W2969587497 cites W2027655034 @default.
• W2969587497 cites W2030642383 @default.
• W2969587497 cites W2032425148 @default.
• W2969587497 cites W2032696674 @default.
• W2969587497 cites W2032919119 @default.
• W2969587497 cites W2037188673 @default.
• W2969587497 cites W2040481506 @default.
• W2969587497 cites W2040519360 @default.
• W2969587497 cites W2040635479 @default.
• W2969587497 cites W2041510403 @default.
• W2969587497 cites W2042150160 @default.
• W2969587497 cites W2043324403 @default.
• W2969587497 cites W2047254315 @default.
• W2969587497 cites W2049836150 @default.
• W2969587497 cites W2052478346 @default.
• W2969587497 cites W2053307994 @default.
• W2969587497 cites W2053391380 @default.
• W2969587497 cites W2053902607 @default.
• W2969587497 cites W2054984901 @default.
• W2969587497 cites W2055313665 @default.
• W2969587497 cites W2055412943 @default.
• W2969587497 cites W2057082801 @default.
• W2969587497 cites W2057217096 @default.
• W2969587497 cites W2058767592 @default.
• W2969587497 cites W2061543605 @default.
• W2969587497 cites W2062877496 @default.
• W2969587497 cites W2063708051 @default.
• W2969587497 cites W2064039435 @default.
• W2969587497 cites W2065677411 @default.

• next