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- W2969596592 abstract "Quantification of T-cell receptor excision circles (TRECs) has impacted on human T-cell research, but interpretations on T-cell replication have been limited due to the lack of a genomic coding joint. We here overcome this limitation with multiplex TRG rearrangement quantification (detecting ~0.98 alleles per TCRαβ+ T cell) and the HSB-2 cell line with a retrovirally introduced TREC construct. We uncovered 10 cell divisions in effector memory T-cell subsets. Furthermore, we show that TREC dilution with age in healthy adults results mainly from increased T cell replication history. This proliferation was significantly increased in patients with predominantly antibody deficiency. Finally, Guthrie cards of neonates with Down syndrome have fewer T and B cells than controls, with similar T-cell and slightly higher B-cell replication. Thus, combined analysis of TRG coding joints and TREC signal joints can be utilized to quantify in vivo T-cell replication, and has direct applications for research into ageing, immunodeficiency and newborn screening." @default.
- W2969596592 created "2019-08-29" @default.
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- W2969596592 date "2019-08-29" @default.
- W2969596592 modified "2023-09-26" @default.
- W2969596592 title "Quantification of T-Cell and B-Cell Replication History in Aging, Immunodeficiency, and Newborn Screening" @default.
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- W2969596592 doi "https://doi.org/10.3389/fimmu.2019.02084" @default.
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