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• W2969596680 abstract "MAIT cells are an unconventional T cell population that can be activated through both TCR-dependent and TCR-independent mechanisms. Here, we examined the impact of combinations of TCR-dependent and TCR-independent signals in human CD8+ MAIT cells. TCR-independent activation of these MAIT cells from blood and gut was maximized by extending the panel of cytokines to include TNF-superfamily member TL1A. RNA-seq experiments revealed that TCR-dependent and TCR-independent signals drive MAIT cells to exert overlapping and specific effector functions, affecting both host defense and tissue homeostasis. Although TCR triggering alone is insufficient to drive sustained activation, TCR-triggered MAIT cells showed specific enrichment of tissue-repair functions at the gene and protein levels and in in vitro assays. Altogether, these data indicate the blend of TCR-dependent and TCR-independent signaling to CD8+ MAIT cells may play a role in controlling the balance between healthy and pathological processes of tissue inflammation and repair." @default.
• W2969596680 created "2019-08-29" @default.
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• W2969596680 date "2019-09-01" @default.
• W2969596680 modified "2023-10-17" @default.
• W2969596680 title "TCR and Inflammatory Signals Tune Human MAIT Cells to Exert Specific Tissue Repair and Effector Functions" @default.
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• W2969596680 doi "https://doi.org/10.1016/j.celrep.2019.08.050" @default.
• W2969596680 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6899450" @default.
• W2969596680 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31533032" @default.
• W2969596680 hasPublicationYear "2019" @default.
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