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• W2969603676 abstract "While beta 2 ‐adrenoceptor stimulation has been shown to increase lean mass and to alter metabolic properties of skeletal muscle, adaptations in muscle oxidative enzymes and maximal oxygen uptake ( O 2max ) in response to beta 2 ‐adrenergic agonist treatment are inadequately explored in humans, particularly in association with resistance training. Herein, we investigated beta 2 ‐adrenergic‐induced changes in O 2max , leg and arm composition, and muscle content of oxidative enzymes in response to treatment with the selective beta 2 ‐adrenergic agonist terbutaline with and without concurrent resistance training in young men. Forty‐six subjects were randomized to 4 weeks of lifestyle maintenance (n = 23) or resistance training (n = 23). Within the lifestyle maintenance and resistance training group, subjects received daily terbutaline (8 × 0.5 mg) (n = 13) or placebo (n = 10) treatment. No apparent treatment by training interactions was observed during the study period. Terbutaline increased leg and arm lean mass with the intervention, whereas no treatment differences were observed in absolute O 2max and incremental peak power output (iPPO). Treatment main effects were observed for O 2 ‐reserve ( P < .05), O 2max relative to body mass ( P < .05), O 2max relative to leg lean mass ( P < .01), and iPPO relative to leg lean mass, in which terbutaline had a negative effect compared with placebo. Furthermore, content of electron transport chain complex I‐V decreased by 11% ( P < .05) for terbutaline compared with placebo. Accordingly, chronic treatment with the selective beta 2 ‐adrenergic agonist terbutaline may negatively affect O 2max and iPPO in relative terms, but not in absolute." @default.
• W2969603676 created "2019-08-29" @default.
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• W2969603676 date "2019-09-13" @default.
• W2969603676 modified "2023-10-16" @default.
• W2969603676 title "Effect of beta₂‐adrenergic agonist and resistance training on maximal oxygen uptake and muscle oxidative enzymes in men" @default.
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• W2969603676 doi "https://doi.org/10.1111/sms.13544" @default.
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