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• W2969605349 abstract "<ns4:p><ns4:bold>Background:</ns4:bold> The diagnostic utility of the <ns4:italic>Mycobacteria tuberculosis</ns4:italic> lipoarabinomannan (TB-LAM) antigen lateral flow assay on cerebrospinal fluid (CSF) for the diagnosis of tuberculous meningitis (TBM) has not been extensively studied and the few published studies have conflicting results.</ns4:p><ns4:p> <ns4:bold>Methods:</ns4:bold> Lumbar CSF from 59 HIV-positive patients with suspected TBM was tested with TB-LAM and Xpert MTB/Rif Ultra. The diagnostic performance of CSF TB-LAM was compared to positive CSF Xpert MTB/Rif Ultra (definite TBM) and a composite reference of probable or definite TBM according to the uniform case definition. </ns4:p><ns4:p> <ns4:bold>Results:</ns4:bold> Of 59 subjects, 12 (20%) had definite TBM and five (9%) had probable TBM. With reference to definite TBM, CSF TB-LAM assay had a diagnostic sensitivity of 33% and specificity of 96%. When compared to a composite reference of definite or probable TBM, the sensitivity was 24% and specificity was 95%. There were two false positive tests with TB-LAM (3+ grade). In-hospital mortality in CSF TB-LAM positive patients was 17% compared to 0% in those with definite TBM by Xpert MTB/Rif Ultra but negative LAM.</ns4:p><ns4:p> <ns4:bold>Conclusions:</ns4:bold> Lumbar CSF TB-LAM has a poor performance in diagnosing TBM. Both urine TB-LAM and Xpert Ultra should be further investigated in the diagnosis of TBM.</ns4:p>" @default.
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• W2969605349 date "2019-09-30" @default.
• W2969605349 modified "2023-10-14" @default.
• W2969605349 title "Performance of Lipoarabinomannan Assay using Cerebrospinal fluid for the diagnosis of Tuberculous meningitis among HIV patients" @default.
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• W2969605349 doi "https://doi.org/10.12688/wellcomeopenres.15389.2" @default.
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