FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2969609962> ?p ?o ?g. }

• W2969609962 abstract "Neointimal hyperplasia and its related arterial stiffness are the crucial pathophysiological features in atherosclerosis and in-stent restenosis. Cluster of differentiation 147 (CD147), a member of the immunoglobulin super family that induces the expression of matrix metalloproteinase-9 (MMP-9) by dimerization, may play important roles in neointimal hyperplasia and may therefore be an effective target for the treatment of this condition. Here, we investigated whether a novel CD147 inhibitor SP-8356 ((1S,5R)-4-(3,4-dihydroxy-5-methoxystyryl)-6,6-dimethylbicyclo[3.1.1]hept-3-en-2-one) reduces neointimal hyperplasia and arterial stiffness in a rat model of partial carotid artery ligation.Neointimal hyperplasia was induced in Sprague-Dawley rats by partial ligation of the right carotid artery combined with a high fat diet and vitamin D injection. Rats were subdivided into vehicle, SP-8356 (50 mg/kg), and rosuvastatin (10 mg/kg) groups. The drugs were administrated via intraperitoneal injections for 4 weeks. The elasticity of blood vessels was assessed by measuring pulse wave velocity using Doppler ultrasonography before sacrifice. Histomolecular analysis was carried out on harvested carotid arteries.SP-8356 significantly reduced MMP activity by inhibiting CD147 dimerization. SP-8356 reduced neointimal hyperplasia and prevented the deterioration of vascular elasticity. SP-8356 had a greater inhibitory effect on neointimal hyperplasia than did rosuvastatin. Furthermore, rosuvastatin did not improve vascular elasticity. SP-8356 increased the expression of smooth muscle myosin heavy chain (SM-MHC), but decreased the expression of collagen type III and MMP-9 in the neointimal region. In contrast to SP-8356, rosuvastatin did not alter the expression of SM-MHC or MMP-9.The ability of SP-8356 to reduce neointimal hyperplasia and improve arterial stiffness in affected carotid artery suggests that SP-8356 could be a promising therapeutic drug for vascular remodeling disorders involving neointimal hyperplasia and arterial stiffness." @default.
• W2969609962 created "2019-08-29" @default.
• W2969609962 creator A5002587541 @default.
• W2969609962 creator A5007506402 @default.
• W2969609962 creator A5012354889 @default.
• W2969609962 creator A5019266518 @default.
• W2969609962 creator A5032966324 @default.
• W2969609962 creator A5035611667 @default.
• W2969609962 creator A5048288085 @default.
• W2969609962 creator A5056087942 @default.
• W2969609962 creator A5056264201 @default.
• W2969609962 creator A5064301886 @default.
• W2969609962 date "2019-08-20" @default.
• W2969609962 modified "2023-10-12" @default.
• W2969609962 title "A novel CD147 inhibitor, SP-8356, reduces neointimal hyperplasia and arterial stiffness in a rat model of partial carotid artery ligation" @default.
• W2969609962 cites W122349615 @default.
• W2969609962 cites W1971428935 @default.
• W2969609962 cites W1971772156 @default.
• W2969609962 cites W1978235376 @default.
• W2969609962 cites W1986238394 @default.
• W2969609962 cites W1987430295 @default.
• W2969609962 cites W1989281040 @default.
• W2969609962 cites W1989556574 @default.
• W2969609962 cites W1994061224 @default.
• W2969609962 cites W2001608284 @default.
• W2969609962 cites W2013410335 @default.
• W2969609962 cites W2019654234 @default.
• W2969609962 cites W2020786788 @default.
• W2969609962 cites W2029623922 @default.
• W2969609962 cites W2039068212 @default.
• W2969609962 cites W2042362499 @default.
• W2969609962 cites W2042477615 @default.
• W2969609962 cites W2048639618 @default.
• W2969609962 cites W2077426548 @default.
• W2969609962 cites W2080809427 @default.
• W2969609962 cites W2083630382 @default.
• W2969609962 cites W2084702397 @default.
• W2969609962 cites W2101848599 @default.
• W2969609962 cites W2103684777 @default.
• W2969609962 cites W2104842795 @default.
• W2969609962 cites W2106494357 @default.
• W2969609962 cites W2109068464 @default.
• W2969609962 cites W2114371777 @default.
• W2969609962 cites W2121822802 @default.
• W2969609962 cites W2128829706 @default.
• W2969609962 cites W2133681759 @default.
• W2969609962 cites W2139007003 @default.
• W2969609962 cites W2141689513 @default.
• W2969609962 cites W2143689100 @default.
• W2969609962 cites W2145540521 @default.
• W2969609962 cites W2145865564 @default.
• W2969609962 cites W2151600317 @default.
• W2969609962 cites W2161092372 @default.
• W2969609962 cites W2163627991 @default.
• W2969609962 cites W2194180664 @default.
• W2969609962 cites W2275603548 @default.
• W2969609962 cites W2280193287 @default.
• W2969609962 cites W2413045839 @default.
• W2969609962 cites W2568907915 @default.
• W2969609962 cites W2737009342 @default.
• W2969609962 cites W2737249697 @default.
• W2969609962 cites W2900034165 @default.
• W2969609962 cites W2941864514 @default.
• W2969609962 cites W3006057482 @default.
• W2969609962 cites W4234610775 @default.
• W2969609962 cites W4296979652 @default.
• W2969609962 doi "https://doi.org/10.1186/s12967-019-2024-y" @default.
• W2969609962 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6700999" @default.
• W2969609962 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31429778" @default.
• W2969609962 hasPublicationYear "2019" @default.
• W2969609962 type Work @default.
• W2969609962 sameAs 2969609962 @default.
• W2969609962 citedByCount "14" @default.
• W2969609962 countsByYear W29696099622019 @default.
• W2969609962 countsByYear W29696099622020 @default.
• W2969609962 countsByYear W29696099622021 @default.
• W2969609962 countsByYear W29696099622022 @default.
• W2969609962 countsByYear W29696099622023 @default.
• W2969609962 crossrefType "journal-article" @default.
• W2969609962 hasAuthorship W2969609962A5002587541 @default.
• W2969609962 hasAuthorship W2969609962A5007506402 @default.
• W2969609962 hasAuthorship W2969609962A5012354889 @default.
• W2969609962 hasAuthorship W2969609962A5019266518 @default.
• W2969609962 hasAuthorship W2969609962A5032966324 @default.
• W2969609962 hasAuthorship W2969609962A5035611667 @default.
• W2969609962 hasAuthorship W2969609962A5048288085 @default.
• W2969609962 hasAuthorship W2969609962A5056087942 @default.
• W2969609962 hasAuthorship W2969609962A5056264201 @default.
• W2969609962 hasAuthorship W2969609962A5064301886 @default.
• W2969609962 hasBestOaLocation W29696099621 @default.
• W2969609962 hasConcept C126322002 @default.
• W2969609962 hasConcept C126894567 @default.
• W2969609962 hasConcept C134018914 @default.
• W2969609962 hasConcept C164705383 @default.
• W2969609962 hasConcept C2775850156 @default.
• W2969609962 hasConcept C2776820930 @default.
• W2969609962 hasConcept C2777562237 @default.
• W2969609962 hasConcept C2778095995 @default.
• W2969609962 hasConcept C2778283817 @default.
• W2969609962 hasConcept C2778583881 @default.

• next