FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2969621269> ?p ?o ?g. }

• W2969621269 endingPage "901" @default.
• W2969621269 startingPage "888" @default.
• W2969621269 abstract "The genomes of classical inbred mouse strains include genes derived from all three major subspecies of the house mouse, Mus musculus. We recently posited that genetic diversity in the immunoglobulin heavy chain (IGH) gene loci of C57BL/6 and BALB/c mice reflects differences in subspecies origin. To investigate this hypothesis, we conducted high-throughput sequencing of IGH gene rearrangements to document IGH variable (IGHV), joining (IGHJ) and diversity (IGHD) genes in four inbred wild-derived mouse strains (CAST/EiJ, LEWES/EiJ, MSM/MsJ and PWD/PhJ) and a single disease model strain (NOD/ShiLtJ), collectively representing genetic backgrounds of several major mouse subspecies. A total of 341 germline IGHV sequences were inferred in the wild-derived strains, including 247 not curated in the international ImMunoGeneTics information system. By contrast, 83/84 inferred NOD IGHV genes had previously been observed in C57BL/6 mice. Variability among the strains examined was observed for only a single IGHJ gene, involving a description of a novel allele. By contrast, unexpected variation was found in the IGHD gene loci, with four previously unreported IGHD gene sequences being documented. Very few IGHV sequences of C57BL/6 and BALB/c mice were shared with strains representing major subspecies, suggesting that their IGH loci may be complex mosaics of genes of disparate origins. This suggests a similar level of diversity is likely present in the IGH loci of other classical inbred strains. This must now be documented if we are to properly understand interstrain variation in models of antibody-mediated disease." @default.
• W2969621269 created "2019-08-29" @default.
• W2969621269 creator A5018874456 @default.
• W2969621269 creator A5046914096 @default.
• W2969621269 creator A5058637612 @default.
• W2969621269 creator A5060732193 @default.
• W2969621269 creator A5069859112 @default.
• W2969621269 creator A5070069186 @default.
• W2969621269 creator A5076862428 @default.
• W2969621269 creator A5081869707 @default.
• W2969621269 creator A5089821124 @default.
• W2969621269 date "2019-10-06" @default.
• W2969621269 modified "2023-10-14" @default.
• W2969621269 title "A comparison of immunoglobulin <scp>IGHV</scp> , <scp>IGHD</scp> and <scp>IGHJ</scp> genes in wild‐derived and classical inbred mouse strains" @default.
• W2969621269 cites W1024729339 @default.
• W2969621269 cites W141842221 @default.
• W2969621269 cites W1525464385 @default.
• W2969621269 cites W1571396434 @default.
• W2969621269 cites W1576688622 @default.
• W2969621269 cites W1582994102 @default.
• W2969621269 cites W1607133945 @default.
• W2969621269 cites W1737898466 @default.
• W2969621269 cites W1940341482 @default.
• W2969621269 cites W1948278385 @default.
• W2969621269 cites W1967505760 @default.
• W2969621269 cites W1969701389 @default.
• W2969621269 cites W1972884489 @default.
• W2969621269 cites W2010776654 @default.
• W2969621269 cites W2026176809 @default.
• W2969621269 cites W2029525307 @default.
• W2969621269 cites W2029627165 @default.
• W2969621269 cites W2038692332 @default.
• W2969621269 cites W2041309682 @default.
• W2969621269 cites W2055043387 @default.
• W2969621269 cites W2068310820 @default.
• W2969621269 cites W2090081965 @default.
• W2969621269 cites W2097606916 @default.
• W2969621269 cites W2103199042 @default.
• W2969621269 cites W2113392525 @default.
• W2969621269 cites W2118218075 @default.
• W2969621269 cites W2123789998 @default.
• W2969621269 cites W2125748493 @default.
• W2969621269 cites W2127783517 @default.
• W2969621269 cites W2129964163 @default.
• W2969621269 cites W2136145671 @default.
• W2969621269 cites W2151558930 @default.
• W2969621269 cites W2155985608 @default.
• W2969621269 cites W2337033889 @default.
• W2969621269 cites W2547929624 @default.
• W2969621269 cites W2565989705 @default.
• W2969621269 cites W2593304502 @default.
• W2969621269 cites W2615390960 @default.
• W2969621269 cites W2768215828 @default.
• W2969621269 cites W2780245662 @default.
• W2969621269 cites W2790409745 @default.
• W2969621269 cites W2889496138 @default.
• W2969621269 cites W2896528863 @default.
• W2969621269 cites W2912715963 @default.
• W2969621269 cites W2922017807 @default.
• W2969621269 cites W2950234903 @default.
• W2969621269 cites W4248060226 @default.
• W2969621269 cites W937578315 @default.
• W2969621269 doi "https://doi.org/10.1111/imcb.12288" @default.
• W2969621269 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31441114" @default.
• W2969621269 hasPublicationYear "2019" @default.
• W2969621269 type Work @default.
• W2969621269 sameAs 2969621269 @default.
• W2969621269 citedByCount "23" @default.
• W2969621269 countsByYear W29696212692019 @default.
• W2969621269 countsByYear W29696212692020 @default.
• W2969621269 countsByYear W29696212692021 @default.
• W2969621269 countsByYear W29696212692022 @default.
• W2969621269 countsByYear W29696212692023 @default.
• W2969621269 crossrefType "journal-article" @default.
• W2969621269 hasAuthorship W2969621269A5018874456 @default.
• W2969621269 hasAuthorship W2969621269A5046914096 @default.
• W2969621269 hasAuthorship W2969621269A5058637612 @default.
• W2969621269 hasAuthorship W2969621269A5060732193 @default.
• W2969621269 hasAuthorship W2969621269A5069859112 @default.
• W2969621269 hasAuthorship W2969621269A5070069186 @default.
• W2969621269 hasAuthorship W2969621269A5076862428 @default.
• W2969621269 hasAuthorship W2969621269A5081869707 @default.
• W2969621269 hasAuthorship W2969621269A5089821124 @default.
• W2969621269 hasBestOaLocation W29696212692 @default.
• W2969621269 hasConcept C104317684 @default.
• W2969621269 hasConcept C109825262 @default.
• W2969621269 hasConcept C151730666 @default.
• W2969621269 hasConcept C17966761 @default.
• W2969621269 hasConcept C180754005 @default.
• W2969621269 hasConcept C2777609679 @default.
• W2969621269 hasConcept C2777938653 @default.
• W2969621269 hasConcept C2778461978 @default.
• W2969621269 hasConcept C2779430528 @default.
• W2969621269 hasConcept C2779952775 @default.
• W2969621269 hasConcept C2984496839 @default.
• W2969621269 hasConcept C54355233 @default.
• W2969621269 hasConcept C55493867 @default.
• W2969621269 hasConcept C71315377 @default.

• next