FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2969622008> ?p ?o ?g. }

• W2969622008 endingPage "1212" @default.
• W2969622008 startingPage "1212" @default.
• W2969622008 abstract "(1) Background: Markers identifying which patients with metastatic, castration-resistant prostate cancer (mCRPC) will benefit from cabazitaxel therapy are currently lacking. Therefore, the aim of this study was to identify markers associated with outcome to cabazitaxel therapy based on counts and gene expression profiles of circulating tumor cells (CTCs). (2) Methods: From 120 mCRPC patients, CellSearch enriched CTCs were obtained at baseline and after 6 weeks of cabazitaxel therapy. Furthermore, 91 genes associated with prostate cancer were measured in mRNA of these CTCs. (3) Results: In 114 mCRPC patients with an evaluable CTC count, the CTC count was independently associated with poor progression-free survival (PFS) and overall survival (OS) in multivariable analysis with other commonly used variables associated with outcome in mCRPC (age, prostate specific antigen (PSA), alkaline phosphatase, lactate dehydrogenase (LDH), albumin, hemoglobin), together with alkaline phosphatase and hemoglobin. A five-gene expression profile was generated to predict for outcome to cabazitaxel therapy. However, even though this signature was associated with OS in univariate analysis, this was not the case in the multivariate analysis for OS nor for PFS. (4) Conclusion: The established five-gene expression profile in CTCs was not independently associated with PFS nor OS. However, along with alkaline phosphatase and hemoglobin, CTC-count is independently associated with PFS and OS in mCRPC patients who are treated with cabazitaxel." @default.
• W2969622008 created "2019-08-29" @default.
• W2969622008 creator A5014770720 @default.
• W2969622008 creator A5016446106 @default.
• W2969622008 creator A5020320519 @default.
• W2969622008 creator A5041093711 @default.
• W2969622008 creator A5041610986 @default.
• W2969622008 creator A5045236213 @default.
• W2969622008 creator A5045768916 @default.
• W2969622008 creator A5047764279 @default.
• W2969622008 creator A5047837719 @default.
• W2969622008 creator A5047950538 @default.
• W2969622008 creator A5048772815 @default.
• W2969622008 creator A5059230608 @default.
• W2969622008 creator A5066926133 @default.
• W2969622008 creator A5071991781 @default.
• W2969622008 creator A5074174053 @default.
• W2969622008 creator A5078332643 @default.
• W2969622008 creator A5086664857 @default.
• W2969622008 date "2019-08-20" @default.
• W2969622008 modified "2023-10-18" @default.
• W2969622008 title "Circulating Tumor Cell Enumeration and Characterization in Metastatic Castration-Resistant Prostate Cancer Patients Treated with Cabazitaxel" @default.
• W2969622008 cites W1590537329 @default.
• W2969622008 cites W1701091641 @default.
• W2969622008 cites W1844925317 @default.
• W2969622008 cites W1965512352 @default.
• W2969622008 cites W1968700783 @default.
• W2969622008 cites W1986870905 @default.
• W2969622008 cites W1989188477 @default.
• W2969622008 cites W2004273376 @default.
• W2969622008 cites W2007521294 @default.
• W2969622008 cites W2071848647 @default.
• W2969622008 cites W2100115202 @default.
• W2969622008 cites W2101500128 @default.
• W2969622008 cites W2110534364 @default.
• W2969622008 cites W2112564453 @default.
• W2969622008 cites W2117460748 @default.
• W2969622008 cites W2120292596 @default.
• W2969622008 cites W2121158863 @default.
• W2969622008 cites W2123526148 @default.
• W2969622008 cites W2127307826 @default.
• W2969622008 cites W2128571346 @default.
• W2969622008 cites W2133643999 @default.
• W2969622008 cites W2147011132 @default.
• W2969622008 cites W2148643283 @default.
• W2969622008 cites W2148998801 @default.
• W2969622008 cites W2153641732 @default.
• W2969622008 cites W2156923287 @default.
• W2969622008 cites W2159431488 @default.
• W2969622008 cites W2159771669 @default.
• W2969622008 cites W2165834169 @default.
• W2969622008 cites W2166918329 @default.
• W2969622008 cites W2166934351 @default.
• W2969622008 cites W2171855608 @default.
• W2969622008 cites W2360784951 @default.
• W2969622008 cites W2507921127 @default.
• W2969622008 cites W2527922674 @default.
• W2969622008 cites W2565164025 @default.
• W2969622008 cites W2586687042 @default.
• W2969622008 cites W2615103477 @default.
• W2969622008 cites W2754574141 @default.
• W2969622008 cites W2765682155 @default.
• W2969622008 cites W2782421307 @default.
• W2969622008 cites W2785454704 @default.
• W2969622008 cites W2800108237 @default.
• W2969622008 cites W2808859772 @default.
• W2969622008 cites W2954242906 @default.
• W2969622008 cites W4252240244 @default.
• W2969622008 cites W913623683 @default.
• W2969622008 doi "https://doi.org/10.3390/cancers11081212" @default.
• W2969622008 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6721462" @default.
• W2969622008 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31434336" @default.
• W2969622008 hasPublicationYear "2019" @default.
• W2969622008 type Work @default.
• W2969622008 sameAs 2969622008 @default.
• W2969622008 citedByCount "18" @default.
• W2969622008 countsByYear W29696220082020 @default.
• W2969622008 countsByYear W29696220082021 @default.
• W2969622008 countsByYear W29696220082022 @default.
• W2969622008 countsByYear W29696220082023 @default.
• W2969622008 crossrefType "journal-article" @default.
• W2969622008 hasAuthorship W2969622008A5014770720 @default.
• W2969622008 hasAuthorship W2969622008A5016446106 @default.
• W2969622008 hasAuthorship W2969622008A5020320519 @default.
• W2969622008 hasAuthorship W2969622008A5041093711 @default.
• W2969622008 hasAuthorship W2969622008A5041610986 @default.
• W2969622008 hasAuthorship W2969622008A5045236213 @default.
• W2969622008 hasAuthorship W2969622008A5045768916 @default.
• W2969622008 hasAuthorship W2969622008A5047764279 @default.
• W2969622008 hasAuthorship W2969622008A5047837719 @default.
• W2969622008 hasAuthorship W2969622008A5047950538 @default.
• W2969622008 hasAuthorship W2969622008A5048772815 @default.
• W2969622008 hasAuthorship W2969622008A5059230608 @default.
• W2969622008 hasAuthorship W2969622008A5066926133 @default.
• W2969622008 hasAuthorship W2969622008A5071991781 @default.
• W2969622008 hasAuthorship W2969622008A5074174053 @default.
• W2969622008 hasAuthorship W2969622008A5078332643 @default.
• W2969622008 hasAuthorship W2969622008A5086664857 @default.

• next