Matches in SemOpenAlex for { <https://semopenalex.org/work/W2969622512> ?p ?o ?g. }
- W2969622512 endingPage "4156" @default.
- W2969622512 startingPage "4156" @default.
- W2969622512 abstract "Carcinogenesis is a long-drawn, multistep process, in which metastatic spread is an unequivocal hallmark of a poor prognosis. The progression and dissemination of epithelial cancers is commonly thought to rely on the epidermal-mesenchymal transition (EMT) process. During EMT, epithelial cells lose their junctions and apical-basal polarity, and they acquire a mesenchymal phenotype with its migratory and invasive capabilities. One of the proteins involved in cancer progression and EMT may be SATB1 (Special AT-Rich Binding Protein 1)-a chromatin organiser and a global transcriptional regulator. SATB1 organizes chromatin into spatial loops, providing a docking site necessary for the binding of further transcription factors and chromatin modifying enzymes. SATB1 has the ability to regulate whole sets of genes, even those located on distant chromosomes. SATB1 was found to be overexpressed in numerous malignancies, including lymphomas, breast, colorectal, prostate, liver, bladder and ovarian cancers. In the solid tumours, an elevated SATB1 level was observed to be associated with an aggressive phenotype, presence of lymph node, distant metastases, and a poor prognosis. In this review, we briefly describe the prognostic significance of SATB1 expression in most common human cancers, and analyse its impact on EMT and metastasis." @default.
- W2969622512 created "2019-08-29" @default.
- W2969622512 creator A5006799780 @default.
- W2969622512 creator A5014093784 @default.
- W2969622512 creator A5077637242 @default.
- W2969622512 creator A5081423888 @default.
- W2969622512 date "2019-08-25" @default.
- W2969622512 modified "2023-10-18" @default.
- W2969622512 title "The Role of SATB1 in Tumour Progression and Metastasis" @default.
- W2969622512 cites W1483547637 @default.
- W2969622512 cites W1536175448 @default.
- W2969622512 cites W1585500207 @default.
- W2969622512 cites W1589859814 @default.
- W2969622512 cites W1663117206 @default.
- W2969622512 cites W1760215417 @default.
- W2969622512 cites W1814192473 @default.
- W2969622512 cites W1953677527 @default.
- W2969622512 cites W1964847767 @default.
- W2969622512 cites W1966749931 @default.
- W2969622512 cites W1969022350 @default.
- W2969622512 cites W1972126509 @default.
- W2969622512 cites W1976957284 @default.
- W2969622512 cites W1977040692 @default.
- W2969622512 cites W1978334713 @default.
- W2969622512 cites W1980504035 @default.
- W2969622512 cites W1985727076 @default.
- W2969622512 cites W1985969740 @default.
- W2969622512 cites W1992839991 @default.
- W2969622512 cites W1995150248 @default.
- W2969622512 cites W1996340200 @default.
- W2969622512 cites W1997590529 @default.
- W2969622512 cites W1999158919 @default.
- W2969622512 cites W2000771269 @default.
- W2969622512 cites W2001002143 @default.
- W2969622512 cites W2005856770 @default.
- W2969622512 cites W2006779861 @default.
- W2969622512 cites W2013126388 @default.
- W2969622512 cites W2014357803 @default.
- W2969622512 cites W2021170422 @default.
- W2969622512 cites W2022270234 @default.
- W2969622512 cites W2023016929 @default.
- W2969622512 cites W2027286022 @default.
- W2969622512 cites W2028735619 @default.
- W2969622512 cites W2035565351 @default.
- W2969622512 cites W2045582876 @default.
- W2969622512 cites W2045691092 @default.
- W2969622512 cites W2049362398 @default.
- W2969622512 cites W2051886524 @default.
- W2969622512 cites W2062860528 @default.
- W2969622512 cites W2064210010 @default.
- W2969622512 cites W2066861312 @default.
- W2969622512 cites W2068258525 @default.
- W2969622512 cites W2069441091 @default.
- W2969622512 cites W2071359561 @default.
- W2969622512 cites W2073876158 @default.
- W2969622512 cites W2074998657 @default.
- W2969622512 cites W2077098920 @default.
- W2969622512 cites W2081160997 @default.
- W2969622512 cites W2093921289 @default.
- W2969622512 cites W2096136519 @default.
- W2969622512 cites W2096171314 @default.
- W2969622512 cites W2096966618 @default.
- W2969622512 cites W2099570464 @default.
- W2969622512 cites W2101547995 @default.
- W2969622512 cites W2104837386 @default.
- W2969622512 cites W2109046342 @default.
- W2969622512 cites W2111349745 @default.
- W2969622512 cites W2114890543 @default.
- W2969622512 cites W2115946406 @default.
- W2969622512 cites W2116426583 @default.
- W2969622512 cites W2121843207 @default.
- W2969622512 cites W2122026938 @default.
- W2969622512 cites W2123739595 @default.
- W2969622512 cites W2123899702 @default.
- W2969622512 cites W2124493013 @default.
- W2969622512 cites W2125462227 @default.
- W2969622512 cites W2128985829 @default.
- W2969622512 cites W2132966617 @default.
- W2969622512 cites W2136433116 @default.
- W2969622512 cites W2142577487 @default.
- W2969622512 cites W2151502444 @default.
- W2969622512 cites W2156475356 @default.
- W2969622512 cites W2158487422 @default.
- W2969622512 cites W2163376464 @default.
- W2969622512 cites W2167255821 @default.
- W2969622512 cites W2168133254 @default.
- W2969622512 cites W2173769238 @default.
- W2969622512 cites W2178296763 @default.
- W2969622512 cites W2244706322 @default.
- W2969622512 cites W2263250795 @default.
- W2969622512 cites W2267515184 @default.
- W2969622512 cites W2268501842 @default.
- W2969622512 cites W2284495907 @default.
- W2969622512 cites W2284979644 @default.
- W2969622512 cites W2328102295 @default.
- W2969622512 cites W2340861535 @default.
- W2969622512 cites W2341148711 @default.
- W2969622512 cites W2346779904 @default.