FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2969626083> ?p ?o ?g. }

• W2969626083 endingPage "3540" @default.
• W2969626083 startingPage "3518" @default.
• W2969626083 abstract "Introduction: Curcumin has remarkable pharmacological activities but remains clinically constrained due to its poor bioavailability as a result of insolubility. This has necessitated the search for natural inorganic materials for curcumin delivery. Cockleshells are external hard materials of marine animals often treated as unwanted wastes, which are excellent sources of calcium carbonate. This study aimed to synthesize cockle shell-derived calcium carbonate (aragonite) nanoparticles (CSCaCO3NP) for delivery of curcumin and to evaluate its kinetic release in vitro. Methods: CSCaCO3NP was synthesized and conjugated with curcumin (Cur-CSCaCO3NP) using a simple top down approach and characterized for its physicochemical properties as a potential curcumin carrier. The in vitro release profile was assessed using the dialysis bag membrane method. The release data were fitted to Korsmeyer-Peppas, Zero order, and Higuchi models to evaluate the mechanism(s) of the release pattern. Results: A spherical shaped CSCaCO3NP with a surface area of 14.48+/-0.1 m2/g, with mean diameter size of 21.38+/-2.7 nm and zeta potential of -18.7 mV, was synthesized and found to have high loading content and encapsulation efficiency. The FT-IR and XRD revealed fewer observable changes on the peaks after conjugation. The profile of the in vitro kinetic release demonstrated a sustained release, and which was best fitted to the Higuchi equation model. Conclusion: The results of this study showed the capacity of the synthesized CSCaCO3NP to encapsulate curcumin efficiently with a stable release in vitro. This provides insight into and rationale for the potential of CSCaCO3NP for curcumin delivery. Therefore, CSCaCO3NP holds great prospects in the preclinical framework for enhancing curcumin efficacy in oral therapeutic applications. &nbsp" @default.
• W2969626083 created "2019-08-29" @default.
• W2969626083 creator A5017797880 @default.
• W2969626083 creator A5029274574 @default.
• W2969626083 creator A5035540939 @default.
• W2969626083 creator A5049899491 @default.
• W2969626083 creator A5053662595 @default.
• W2969626083 creator A5055745231 @default.
• W2969626083 creator A5071893762 @default.
• W2969626083 date "2019-12-21" @default.
• W2969626083 modified "2023-10-16" @default.
• W2969626083 title "Evaluation of in vitro release kinetics and mechanisms of curcumin-loaded cockle shell-derived calcium carbonate nanoparticles" @default.
• W2969626083 doi "https://doi.org/10.15419/bmrat.v6i12.580" @default.
• W2969626083 hasPublicationYear "2019" @default.
• W2969626083 type Work @default.
• W2969626083 sameAs 2969626083 @default.
• W2969626083 citedByCount "11" @default.
• W2969626083 countsByYear W29696260832020 @default.
• W2969626083 countsByYear W29696260832021 @default.
• W2969626083 countsByYear W29696260832022 @default.
• W2969626083 countsByYear W29696260832023 @default.
• W2969626083 crossrefType "journal-article" @default.
• W2969626083 hasAuthorship W2969626083A5017797880 @default.
• W2969626083 hasAuthorship W2969626083A5029274574 @default.
• W2969626083 hasAuthorship W2969626083A5035540939 @default.
• W2969626083 hasAuthorship W2969626083A5049899491 @default.
• W2969626083 hasAuthorship W2969626083A5053662595 @default.
• W2969626083 hasAuthorship W2969626083A5055745231 @default.
• W2969626083 hasAuthorship W2969626083A5071893762 @default.
• W2969626083 hasBestOaLocation W29696260831 @default.
• W2969626083 hasConcept C121332964 @default.
• W2969626083 hasConcept C12554922 @default.
• W2969626083 hasConcept C127413603 @default.
• W2969626083 hasConcept C13965031 @default.
• W2969626083 hasConcept C148898269 @default.
• W2969626083 hasConcept C155672457 @default.
• W2969626083 hasConcept C163588942 @default.
• W2969626083 hasConcept C171250308 @default.
• W2969626083 hasConcept C178790620 @default.
• W2969626083 hasConcept C181389837 @default.
• W2969626083 hasConcept C185592680 @default.
• W2969626083 hasConcept C192562407 @default.
• W2969626083 hasConcept C199091049 @default.
• W2969626083 hasConcept C202751555 @default.
• W2969626083 hasConcept C2778039128 @default.
• W2969626083 hasConcept C2778250585 @default.
• W2969626083 hasConcept C2779878498 @default.
• W2969626083 hasConcept C41625074 @default.
• W2969626083 hasConcept C42360764 @default.
• W2969626083 hasConcept C505870484 @default.
• W2969626083 hasConcept C55493867 @default.
• W2969626083 hasConcept C62520636 @default.
• W2969626083 hasConcept C71924100 @default.
• W2969626083 hasConcept C86181022 @default.
• W2969626083 hasConcept C86803240 @default.
• W2969626083 hasConcept C98274493 @default.
• W2969626083 hasConceptScore W2969626083C121332964 @default.
• W2969626083 hasConceptScore W2969626083C12554922 @default.
• W2969626083 hasConceptScore W2969626083C127413603 @default.
• W2969626083 hasConceptScore W2969626083C13965031 @default.
• W2969626083 hasConceptScore W2969626083C148898269 @default.
• W2969626083 hasConceptScore W2969626083C155672457 @default.
• W2969626083 hasConceptScore W2969626083C163588942 @default.
• W2969626083 hasConceptScore W2969626083C171250308 @default.
• W2969626083 hasConceptScore W2969626083C178790620 @default.
• W2969626083 hasConceptScore W2969626083C181389837 @default.
• W2969626083 hasConceptScore W2969626083C185592680 @default.
• W2969626083 hasConceptScore W2969626083C192562407 @default.
• W2969626083 hasConceptScore W2969626083C199091049 @default.
• W2969626083 hasConceptScore W2969626083C202751555 @default.
• W2969626083 hasConceptScore W2969626083C2778039128 @default.
• W2969626083 hasConceptScore W2969626083C2778250585 @default.
• W2969626083 hasConceptScore W2969626083C2779878498 @default.
• W2969626083 hasConceptScore W2969626083C41625074 @default.
• W2969626083 hasConceptScore W2969626083C42360764 @default.
• W2969626083 hasConceptScore W2969626083C505870484 @default.
• W2969626083 hasConceptScore W2969626083C55493867 @default.
• W2969626083 hasConceptScore W2969626083C62520636 @default.
• W2969626083 hasConceptScore W2969626083C71924100 @default.
• W2969626083 hasConceptScore W2969626083C86181022 @default.
• W2969626083 hasConceptScore W2969626083C86803240 @default.
• W2969626083 hasConceptScore W2969626083C98274493 @default.
• W2969626083 hasIssue "12" @default.
• W2969626083 hasLocation W29696260831 @default.
• W2969626083 hasLocation W29696260832 @default.
• W2969626083 hasOpenAccess W2969626083 @default.
• W2969626083 hasPrimaryLocation W29696260831 @default.
• W2969626083 hasRelatedWork W1998271063 @default.
• W2969626083 hasRelatedWork W2040902352 @default.
• W2969626083 hasRelatedWork W2321018221 @default.
• W2969626083 hasRelatedWork W2606614729 @default.
• W2969626083 hasRelatedWork W2611594850 @default.
• W2969626083 hasRelatedWork W2790541021 @default.
• W2969626083 hasRelatedWork W2791169112 @default.
• W2969626083 hasRelatedWork W2946385327 @default.
• W2969626083 hasRelatedWork W4293764379 @default.
• W2969626083 hasRelatedWork W4320496217 @default.
• W2969626083 hasVolume "6" @default.

• next