FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2969653708> ?p ?o ?g. }

• W2969653708 endingPage "824" @default.
• W2969653708 startingPage "817" @default.
• W2969653708 abstract "Olfactomedins are a family of modular proteins found in multicellular organisms that all contain five-bladed β-propeller olfactomedin (OLF) domains. In support of differential functions for the OLF propeller, the available crystal structures reveal that only some OLF domains harbor an internal calcium-binding site with ligands derived from a triad of residues. For the myocilin OLF domain (myoc-OLF), ablation of the ion-binding site (triad Asp, Asn, Asp) by altering the coordinating residues affects the stability and overall structure, in one case leading to misfolding and glaucoma. Bioinformatics analysis reveals a variety of triads with possible ion-binding characteristics lurking in OLF domains in invertebrate chordates such as Arthropoda (Asp–Glu–Ser), Nematoda (Asp–Asp–His) and Echinodermata (Asp–Glu–Lys). To test ion binding and to extend the observed connection between ion binding and distal structural rearrangements, consensus triads from these phyla were installed in the myoc-OLF. All three protein variants exhibit wild-type-like or better stability, but their calcium-binding properties differ, concomitant with new structural deviations from wild-type myoc-OLF. Taken together, the results indicate that calcium binding is not intrinsically destabilizing to myoc-OLF or required to observe a well ordered side helix, and that ion binding is a differential feature that may underlie the largely elusive biological function of OLF propellers." @default.
• W2969653708 created "2019-08-29" @default.
• W2969653708 creator A5006996808 @default.
• W2969653708 creator A5053977491 @default.
• W2969653708 creator A5075604712 @default.
• W2969653708 creator A5084821478 @default.
• W2969653708 date "2019-08-22" @default.
• W2969653708 modified "2023-10-14" @default.
• W2969653708 title "Calcium-ligand variants of the myocilin olfactomedin propeller selected from invertebrate phyla reveal cross-talk with N-terminal blade and surface helices" @default.
• W2969653708 cites W1519266993 @default.
• W2969653708 cites W1925010091 @default.
• W2969653708 cites W1946317050 @default.
• W2969653708 cites W1995133011 @default.
• W2969653708 cites W2000434886 @default.
• W2969653708 cites W2003890287 @default.
• W2969653708 cites W2004622806 @default.
• W2969653708 cites W2009189021 @default.
• W2969653708 cites W2012801606 @default.
• W2969653708 cites W2049888624 @default.
• W2969653708 cites W2052524483 @default.
• W2969653708 cites W2066962978 @default.
• W2969653708 cites W2069880676 @default.
• W2969653708 cites W2092146175 @default.
• W2969653708 cites W2092189458 @default.
• W2969653708 cites W2103503400 @default.
• W2969653708 cites W2109395212 @default.
• W2969653708 cites W2116152120 @default.
• W2969653708 cites W2124026197 @default.
• W2969653708 cites W2132926880 @default.
• W2969653708 cites W2150688268 @default.
• W2969653708 cites W2154197653 @default.
• W2969653708 cites W2158266834 @default.
• W2969653708 cites W2163341755 @default.
• W2969653708 cites W2340461165 @default.
• W2969653708 cites W2589875042 @default.
• W2969653708 cites W2924704706 @default.
• W2969653708 cites W2938574745 @default.
• W2969653708 cites W2952716810 @default.
• W2969653708 cites W2955742566 @default.
• W2969653708 cites W4248872320 @default.
• W2969653708 cites W843844753 @default.
• W2969653708 doi "https://doi.org/10.1107/s205979831901074x" @default.
• W2969653708 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6719662" @default.
• W2969653708 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31478904" @default.
• W2969653708 hasPublicationYear "2019" @default.
• W2969653708 type Work @default.
• W2969653708 sameAs 2969653708 @default.
• W2969653708 citedByCount "4" @default.
• W2969653708 countsByYear W29696537082021 @default.
• W2969653708 countsByYear W29696537082023 @default.
• W2969653708 crossrefType "journal-article" @default.
• W2969653708 hasAuthorship W2969653708A5006996808 @default.
• W2969653708 hasAuthorship W2969653708A5053977491 @default.
• W2969653708 hasAuthorship W2969653708A5075604712 @default.
• W2969653708 hasAuthorship W2969653708A5084821478 @default.
• W2969653708 hasBestOaLocation W29696537081 @default.
• W2969653708 hasConcept C104317684 @default.
• W2969653708 hasConcept C107824862 @default.
• W2969653708 hasConcept C122229402 @default.
• W2969653708 hasConcept C167625842 @default.
• W2969653708 hasConcept C178790620 @default.
• W2969653708 hasConcept C185592680 @default.
• W2969653708 hasConcept C42086223 @default.
• W2969653708 hasConcept C47701112 @default.
• W2969653708 hasConcept C519063684 @default.
• W2969653708 hasConcept C55493867 @default.
• W2969653708 hasConcept C71240020 @default.
• W2969653708 hasConcept C8010536 @default.
• W2969653708 hasConcept C86803240 @default.
• W2969653708 hasConcept C91066513 @default.
• W2969653708 hasConceptScore W2969653708C104317684 @default.
• W2969653708 hasConceptScore W2969653708C107824862 @default.
• W2969653708 hasConceptScore W2969653708C122229402 @default.
• W2969653708 hasConceptScore W2969653708C167625842 @default.
• W2969653708 hasConceptScore W2969653708C178790620 @default.
• W2969653708 hasConceptScore W2969653708C185592680 @default.
• W2969653708 hasConceptScore W2969653708C42086223 @default.
• W2969653708 hasConceptScore W2969653708C47701112 @default.
• W2969653708 hasConceptScore W2969653708C519063684 @default.
• W2969653708 hasConceptScore W2969653708C55493867 @default.
• W2969653708 hasConceptScore W2969653708C71240020 @default.
• W2969653708 hasConceptScore W2969653708C8010536 @default.
• W2969653708 hasConceptScore W2969653708C86803240 @default.
• W2969653708 hasConceptScore W2969653708C91066513 @default.
• W2969653708 hasFunder F4320337350 @default.
• W2969653708 hasIssue "9" @default.
• W2969653708 hasLocation W29696537081 @default.
• W2969653708 hasLocation W29696537082 @default.
• W2969653708 hasLocation W29696537083 @default.
• W2969653708 hasLocation W29696537084 @default.
• W2969653708 hasOpenAccess W2969653708 @default.
• W2969653708 hasPrimaryLocation W29696537081 @default.
• W2969653708 hasRelatedWork W1557482814 @default.
• W2969653708 hasRelatedWork W1991622845 @default.
• W2969653708 hasRelatedWork W2001135454 @default.
• W2969653708 hasRelatedWork W2005553213 @default.
• W2969653708 hasRelatedWork W2049188108 @default.
• W2969653708 hasRelatedWork W2516072101 @default.

• next