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- W2969653882 abstract "We report a plasmonic contrast imaging biosensor, RESONATOR. It measures the intensity difference between the pand spolarization images at plasmonic excitation. At plasmonic resonance, only the ppolarization light is excited, while spolarization light remains the same. Image intensity subtraction between both polarizations can eliminate common system noise and enhance sensor resolution. In refractive index measurements, the sensor resolution was found to be 4.36×10 <sup xmlns:mml=http://www.w3.org/1998/Math/MathML xmlns:xlink=http://www.w3.org/1999/xlink>-7</sup> RIU. The plasmonic contrast imaging sensor has further been demonstrated for H3N2 influenza antibody detection and DNA-DNA molecular binding detections. The detection limit was found to be 8.6nM (320 ng mL <sup xmlns:mml=http://www.w3.org/1998/Math/MathML xmlns:xlink=http://www.w3.org/1999/xlink>-1</sup> ) for H3N2 influenza antibodies. This value is 56% and 216% better than the detection limit reported for influenza antibody detection with commercial Biacore systems. A computer controlled device prototype has further been developed based on the optical design, which is ready for various bio-molecular binding detections in medical diagnosis, drug discovery, biological study and environmental monitoring." @default.
- W2969653882 created "2019-08-29" @default.
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- W2969653882 date "2019-12-15" @default.
- W2969653882 modified "2023-10-17" @default.
- W2969653882 title "Plasmonic Contrast Imaging Biosensor for the Detection of H3N2 Influenza Protein-Antibody and DNA-DNA Molecular Binding" @default.
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- W2969653882 doi "https://doi.org/10.1109/jsen.2019.2936623" @default.
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