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- W2969653968 endingPage "109752" @default.
- W2969653968 startingPage "109752" @default.
- W2969653968 abstract "Neuroinflammation and metabolic deficits contribute to the etiology of human affective disorders, such as anxiety and depression. The zebrafish (Danio rerio) has recently emerged as a powerful new model organism in CNS disease modeling. Here, we exposed zebrafish to 2% glucose and 10% cholesterol for 19 days to experimentally induce type 2 diabetes (DM) and to assess stress responses, microglia, inflammation and apoptosis. We analyzed zebrafish anxiety-like behavior in the novel tank and light-dark box (Days 15–16) tests, as well as examined their biochemical and genomic biomarkers (Day 19). Confirming DM-like state in zebrafish, we found higher whole-body glucose, triglyceride, total cholesterol, low-density lipoprotein levels and glucagon mRNA expression, and lower high-density lipoprotein levels. DM zebrafish also showed anxiety-like behavior, elevated whole-body cortisol and cytokines IFN-γ and IL-4, as well as higher brain mRNA expression of the glucocorticoid receptor, CD11b (a microglial biomarker), pro-inflammatory cytokines IL-6 and TNF-α (but not IL-1β or anti-inflammatory cytokines IL-4 and IL-10), GFAP (an astrocytal biomarker), neurotrophin BDNF, its receptors p75 and TrkB, as well as apoptotic Bax and Caspase-3 (but not BCl-2) genes. Collectively, this supports the overlapping nature of DM-related affective pathogenesis and emphasizes the role of peripheral and central inflammation and apoptosis in DM-related affective and neuroendocrine deficits in zebrafish." @default.
- W2969653968 created "2019-08-29" @default.
- W2969653968 creator A5001115050 @default.
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- W2969653968 creator A5049468217 @default.
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- W2969653968 creator A5090570080 @default.
- W2969653968 date "2020-01-01" @default.
- W2969653968 modified "2023-10-03" @default.
- W2969653968 title "High-glucose/high-cholesterol diet in zebrafish evokes diabetic and affective pathogenesis: The role of peripheral and central inflammation, microglia and apoptosis" @default.
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- W2969653968 doi "https://doi.org/10.1016/j.pnpbp.2019.109752" @default.
- W2969653968 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31446160" @default.
- W2969653968 hasPublicationYear "2020" @default.
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