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- W2969657863 abstract "Abstract The parathyroid hormone (PTH)/PTH-related peptide (PTHrP) receptor (PTHR1) is a G-protein-coupled receptor (GPCR) that mediates the actions of PTH and PTHrP through at least two distinct second-messenger pathways, cAMP/PKA and IP3/Ca++/PKC. PTHR1 thus has several different biological functions including the PTH-dependent regulation of calcium and phosphate homeostasis and bone turnover, and in addition to numerous other roles, the PTHrP-dependent differentiation of growth plate chondrocytes and thus bone elongation. Consequently, mutations affecting PTHR1, its two ligands, or the proteins involved in downstream signaling can be the cause of several different disorders affecting mineral ion homeostasis, growth plate biology, and bone and tooth development. Rare human disorders affecting these organ systems were shown to be caused by genetic defects in PTHR1, GNAS, PRKAR1A, PDE4D, PDE3A, and HDAC4 and thus have provided novel insights into the underlying regulatory mechanisms." @default.
- W2969657863 created "2019-08-29" @default.
- W2969657863 creator A5050518805 @default.
- W2969657863 creator A5061211092 @default.
- W2969657863 date "2020-01-01" @default.
- W2969657863 modified "2023-09-27" @default.
- W2969657863 title "Genetic disorders caused by mutations in the parathyroid hormone/parathyroid hormone–related peptide receptor, its ligands, and downstream effector molecules" @default.
- W2969657863 cites W131932620 @default.
- W2969657863 cites W1498147771 @default.
- W2969657863 cites W1527376733 @default.
- W2969657863 cites W1537435549 @default.
- W2969657863 cites W1553594457 @default.
- W2969657863 cites W1581434205 @default.
- W2969657863 cites W1822680090 @default.
- W2969657863 cites W1921707426 @default.
- W2969657863 cites W1964455970 @default.
- W2969657863 cites W1965669105 @default.
- W2969657863 cites W1967883890 @default.
- W2969657863 cites W1968434592 @default.
- W2969657863 cites W1968572877 @default.
- W2969657863 cites W1968714547 @default.
- W2969657863 cites W1968834156 @default.
- W2969657863 cites W1971903604 @default.
- W2969657863 cites W1978635256 @default.
- W2969657863 cites W1978810781 @default.
- W2969657863 cites W1979788141 @default.
- W2969657863 cites W1982216216 @default.
- W2969657863 cites W1982239137 @default.
- W2969657863 cites W1982644868 @default.
- W2969657863 cites W1984325351 @default.
- W2969657863 cites W1985332020 @default.
- W2969657863 cites W1986685849 @default.
- W2969657863 cites W1988250847 @default.
- W2969657863 cites W1988897099 @default.
- W2969657863 cites W1989792612 @default.
- W2969657863 cites W1991168687 @default.
- W2969657863 cites W1992294070 @default.
- W2969657863 cites W1994620081 @default.
- W2969657863 cites W1996477516 @default.
- W2969657863 cites W1996816925 @default.
- W2969657863 cites W1996836065 @default.
- W2969657863 cites W1998616639 @default.
- W2969657863 cites W1999996046 @default.
- W2969657863 cites W2002453823 @default.
- W2969657863 cites W2002643158 @default.
- W2969657863 cites W2006139885 @default.
- W2969657863 cites W2008528474 @default.
- W2969657863 cites W2009153723 @default.
- W2969657863 cites W2009441758 @default.
- W2969657863 cites W2009683617 @default.
- W2969657863 cites W2010599278 @default.
- W2969657863 cites W2010814529 @default.
- W2969657863 cites W2013599591 @default.
- W2969657863 cites W2015183535 @default.
- W2969657863 cites W2015478374 @default.
- W2969657863 cites W2017590649 @default.
- W2969657863 cites W2018381121 @default.
- W2969657863 cites W2018992413 @default.
- W2969657863 cites W2019181219 @default.
- W2969657863 cites W2022764813 @default.
- W2969657863 cites W2023781876 @default.
- W2969657863 cites W2031163899 @default.
- W2969657863 cites W2032795118 @default.
- W2969657863 cites W2034686025 @default.
- W2969657863 cites W2034841837 @default.
- W2969657863 cites W2035892299 @default.
- W2969657863 cites W2037611230 @default.
- W2969657863 cites W2038683631 @default.
- W2969657863 cites W2044608778 @default.
- W2969657863 cites W2051795925 @default.
- W2969657863 cites W2055002656 @default.
- W2969657863 cites W2055612027 @default.
- W2969657863 cites W2056994384 @default.
- W2969657863 cites W2057498103 @default.
- W2969657863 cites W2058838325 @default.
- W2969657863 cites W2062207135 @default.
- W2969657863 cites W2069924084 @default.
- W2969657863 cites W2072334821 @default.
- W2969657863 cites W2073552393 @default.
- W2969657863 cites W2074169344 @default.
- W2969657863 cites W2074706861 @default.
- W2969657863 cites W2074923758 @default.
- W2969657863 cites W2079261818 @default.
- W2969657863 cites W2080448298 @default.
- W2969657863 cites W2080472786 @default.
- W2969657863 cites W2080548729 @default.
- W2969657863 cites W2081500209 @default.
- W2969657863 cites W2082708611 @default.
- W2969657863 cites W2083168164 @default.
- W2969657863 cites W2083300182 @default.
- W2969657863 cites W2083945540 @default.
- W2969657863 cites W2085530184 @default.
- W2969657863 cites W2085811335 @default.
- W2969657863 cites W2088357564 @default.
- W2969657863 cites W2088590824 @default.
- W2969657863 cites W2088677234 @default.
- W2969657863 cites W2089627181 @default.
- W2969657863 cites W2090114948 @default.