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- W2969657956 endingPage "960" @default.
- W2969657956 startingPage "960" @default.
- W2969657956 abstract "Cholangiocarcinoma is a deadly cancer worldwide, associated with a poor prognosis and limited therapeutic options. Although cholangiocarcinoma accounts for less than 15% of liver primary cancer, its silent nature restricts early diagnosis and prevents efficient treatment. Therefore, it is of clinical relevance to better understand the molecular basis of cholangiocarcinoma, including the signaling pathways that contribute to tumor onset and progression. In this review, we discuss the genetic, molecular, and environmental factors that promote cholangiocarcinoma, emphasizing the role of the transforming growth factor β (TGFβ) signaling pathway in the progression of this cancer. We provide an overview of the physiological functions of TGFβ signaling in preserving liver homeostasis and describe how advanced cholangiocarcinoma benefits from the tumor-promoting effects of TGFβ. Moreover, we report the importance of noncoding RNAs as effector molecules downstream of TGFβ during cholangiocarcinoma progression, and conclude by highlighting the need for identifying novel and clinically relevant biomarkers for a better management of patients with cholangiocarcinoma." @default.
- W2969657956 created "2019-08-29" @default.
- W2969657956 creator A5019949662 @default.
- W2969657956 creator A5036056795 @default.
- W2969657956 creator A5046176669 @default.
- W2969657956 date "2019-08-23" @default.
- W2969657956 modified "2023-10-11" @default.
- W2969657956 title "Transforming Growth Factor-Beta (TGFβ) Signaling Pathway in Cholangiocarcinoma" @default.
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