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• W2969658631 abstract "Background: Primary membranous nephropathy (PMN) is an autoimmune disease affecting renal glomerulus, characterized by autoantibodies aggregation on podocytes and subsequent epithelial thickening. Therefore, rituximab, an anti-CD20 monoclonal antibody, is used to treat patients with the deteriorating condition. Objectives: Assuming that rituximab demolishes a considerable number of B-lymphocytes and causes transient immunodeficiency, we aimed to identify B cell subsets involved in PMN pathogenesis to facilitate specific targeting. Methods: Using flowcytometery, 25 PMN patients including 15 on standard treatment and 10 on standard treatment plus rituximab were enrolled to compare with healthy controls. Rituximab-receiving patients were studied before and two months after administration. Results: Neither total CD19+ nor memory B cell percentages showed significant differences between the study groups. However, the number of B regulatory cells (Breg) was lower in both standard-treatment and Rituximab-receiving patients than in controls. Moreover, the percentage of naïve/mature B cells dropped after standard treatment. Conclusions: PMN patients seem to possess an insufficient percentage of Breg cells, which are involved in immunomodulation. Furthermore, the standard-treatment group showed a reduced count of naïve/mature B cells, which constitute a substantial proportion of normal B lymphocytes population." @default.
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• W2969658631 date "2019-08-19" @default.
• W2969658631 modified "2023-10-06" @default.
• W2969658631 title "B Lymphocyte Subset Changes in Primary Membranous Nephropathy" @default.
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• W2969658631 doi "https://doi.org/10.5812/numonthly.96425" @default.
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