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- W2969659329 abstract "Interaction of therapeutic antibodies with complement component C1q are frequently part of pharmaceutical characterization and production process comparability studies. Assays currently used to assess this interaction and/or the activation of the complement cascade are often cumbersome, time consuming or imprecise. We here report the further development, successful qualification and suitability evaluation of an SPR-based C1q binding assay for the characterization of IgG-C1q interactions. We evaluate different IgG subtypes and well-described mutants of IgG1. The assay offers a suitable alternative for extended characterization of interactions of IgG1 and IgG3 with complement component C1q." @default.
- W2969659329 created "2019-08-29" @default.
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- W2969659329 date "2019-09-01" @default.
- W2969659329 modified "2023-09-27" @default.
- W2969659329 title "Qualification of a surface plasmon resonance assay to determine binding of IgG-type antibodies to complement component C1q" @default.
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- W2969659329 doi "https://doi.org/10.1016/j.biologicals.2019.08.004" @default.
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